In vivo prime editing rescues alternating hemiplegia of childhood in mice [0.03%]
体内prime编辑技术可拯救小鼠的儿童交替性偏瘫症状
Alexander A Sousa,Markus Terrey,Holt A Sakai et al.
Alexander A Sousa et al.
Alternating hemiplegia of childhood (AHC) is a neurodevelopmental disorder with no disease-modifying treatment. Mutations in ATP1A3, encoding an Na+/K+ ATPase subunit, cause 70% of AHC cases. Here, we present prime editing (PE) and base edi...
Cell-type-directed network-correcting combination therapy for Alzheimer's disease [0.03%]
针对阿尔茨海默病的细胞类型导向网络纠正型联合治疗
Yaqiao Li,Carlota Pereda Serras,Jessica Blumenfeld et al.
Yaqiao Li et al.
Alzheimer's disease (AD) is a multifactorial neurodegenerative disorder characterized by heterogeneous molecular changes across diverse cell types, posing significant challenges for treatment development. To address this, we introduced a ce...
Small RNAs are modified with N-glycans and displayed on the surface of living cells [0.03%]
小RNAs具有N-聚糖修饰并以细胞表面蛋白形式展示
Ryan A Flynn,Kayvon Pedram,Stacy A Malaker et al.
Ryan A Flynn et al.
Published Erratum
Cell. 2025 Jul 21:S0092-8674(25)00808-6. DOI:10.1016/j.cell.2025.07.019 2025
Regulation of inflammatory responses by pH-dependent transcriptional condensates [0.03%]
由pH值依赖的转录凝聚物介导的炎症反应调节
Zhongyang Wu,Scott D Pope,Nasiha S Ahmed et al.
Zhongyang Wu et al.
Inflammation is an essential defense response but operates at the cost of normal tissue functions. Whether and how the negative impact of inflammation is monitored remains largely unknown. Acidification of the tissue microenvironment is ass...
Structural insights into brain thyroid hormone transport via MCT8 and OATP1C1 [0.03%]
MCT8和OATP1C1转运甲状腺激素进入大脑的结构洞察
Yunhui Ge,Tongyi Dou,Thu Uyen Nguyen et al.
Yunhui Ge et al.
Adequate delivery of thyroid hormones to the brain is crucial for normal neurological development. MCT8 and OATP1C1, two solute carrier (SLC) transporters, mediate the passage of thyroid hormones across the blood-brain barrier and into the ...
Brain endothelial gap junction coupling enables rapid vasodilation propagation during neurovascular coupling [0.03%]
脑内皮细胞间隙连接偶联可使神经血管耦合时血管舒张迅速传播
Trevor Krolak,Luke Kaplan,Kathleen Navas et al.
Trevor Krolak et al.
To meet the brain's moment-to-moment energy demand, neural activation rapidly increases local blood flow. This process, known as neurovascular coupling, involves rapid, coordinated vasodilation of the brain's arterial network. Here, we demo...
Imaging high-frequency voltage dynamics in multiple neuron classes of behaving mammals [0.03%]
成年行为哺乳动物多种神经元类群的高频电压动态影像学研究
Simon Haziza,Radosław Chrapkiewicz,Yanping Zhang et al.
Simon Haziza et al.
Fluorescent genetically encoded voltage indicators report transmembrane potentials of targeted cell types. However, voltage-imaging instrumentation has lacked the sensitivity to track spontaneous or evoked high-frequency voltage oscillation...
Glucose restriction shapes pre-metastatic innate immune landscapes in the lung through exosomal TRAIL [0.03%]
葡萄糖限制通过外泌体TRAIL塑造肺部潜在转移部位的先天性免疫微环境
Cai-Yuan Wu,Chun-Xiang Huang,Xiang-Ming Lao et al.
Cai-Yuan Wu et al.
Targeting glucose metabolism has emerged as a promising strategy for inhibiting tumor growth. However, we herein uncover an unexpected paradox: while glucose deprivation through a low-carbohydrate diet or impaired in situ metabolism suppres...
A postnatal molecular switch drives activity-dependent maturation of parvalbumin interneurons [0.03%]
产后分子开关驱动钙调蛋白中间神经元的活动依赖性成熟
Monika Moissidis,Leyla Abbasova,Martijn Selten et al.
Monika Moissidis et al.
Cortical neurons are specified during embryonic development but often acquire their mature properties at relatively late stages of postnatal development. This delay in terminal differentiation is particularly prominent for fast-spiking parv...
Recessive epistasis of a synonymous mutation confers cucumber domestication through epitranscriptomic regulation [0.03%]
同义突变通过表转录调控制约黄瓜驯化
Tongxu Xin,Zhen Zhang,Yueying Zhang et al.
Tongxu Xin et al.
Published Erratum
Cell. 2025 Jul 15:S0092-8674(25)00795-0. DOI:10.1016/j.cell.2025.07.006 2025