Single-cell spatial transcriptome atlas and whole-brain connectivity of the macaque claustrum [0.03%]
猴扣带单细胞空间转录组和全脑连接图谱
Ying Lei,Yuxuan Liu,Mingli Wang et al.
Ying Lei et al.
Claustrum orchestrates brain functions via its connections with numerous brain regions, but its molecular and cellular organization remains unresolved. Single-nucleus RNA sequencing of 227,750 macaque claustral cells identified 48 transcrip...
Rorγt-positive dendritic cells are required for the induction of peripheral regulatory T cells in response to oral antigens [0.03%]
Rorγt阳性树突细胞对肠道抗原诱导外周调节性T细胞的响应是必须的
Patrick Fernandes Rodrigues,Shitong Wu,Tihana Trsan et al.
Patrick Fernandes Rodrigues et al.
The intestinal immune system maintains tolerance to harmless food proteins and gut microbiota through peripherally derived RORγt+ Tregs (pTregs), which prevent food intolerance and inflammatory bowel disease. Recent studies suggested that ...
PAX translocations remodel mitochondrial metabolism through altered leucine usage in rhabdomyosarcoma [0.03%]
PAX染色体重排通过改变横纹肌肉瘤中的亮氨酸利用来重塑线粒体代谢路径
Bhargab Kalita,Gerard Martinez-Cebrian,Justina McEvoy et al.
Bhargab Kalita et al.
Alveolar rhabdomyosarcoma (ARMS) patients harboring paired-box fusion proteins (PAX3/7-FOXO1) exhibit a greater incidence of tumor relapse, metastasis, and poor survival outcome, thereby underscoring the urgent need to develop effective the...
20 years of histone lysine demethylases: From discovery to the clinic and beyond [0.03%]
组蛋白赖氨酸去甲基酶研究二十年：从发现到临床和以后的发展方向
Zach H Gray,Madison A Honer,Pooja Ghatalia et al.
Zach H Gray et al.
Twenty years ago, histone lysine demethylases (KDMs) were discovered. Since their discovery, they have been increasingly studied and shown to be important across species, development, and diseases. Considerable advances have been made towar...
Alexander M K Rothman,Amir Florentin,Florence Zink et al.
Alexander M K Rothman et al.
Targeting ubiquitin E3 ligases is therapeutically attractive; however, the absence of an active-site pocket impedes computational approaches for identifying inhibitors. In a large, unbiased biochemical screen, we discover inhibitors that bi...
Genetically encoded reporters of actin filament organization in living cells and tissues [0.03%]
活细胞和组织中肌动蛋白丝结构的遗传编码报告基因
Carla Silva Martins,François Iv,Shashi Kumar Suman et al.
Carla Silva Martins et al.
The cytoskeletal protein actin is crucial for cell shape and integrity throughout eukaryotes. Actin filaments perform essential biological functions, including muscle contraction, cell division, and tissue morphogenesis. These diverse activ...
Shuaibing Zhang,Kevin Schlabach,Victor Hugo Pérez Carrillo et al.
Shuaibing Zhang et al.
Amoebal predation exerts a strong evolutionary selection pressure on bacteria, thus driving the development of effective predator-defense strategies. However, little is known about the molecular interplay between bacteria and predators, par...
Milka Doktorova,Jessica L Symons,Xiaoxuan Zhang et al.
Milka Doktorova et al.
Membranes are molecular interfaces that compartmentalize cells to control the flow of nutrients and information. These functions are facilitated by diverse collections of lipids, nearly all of which are distributed asymmetrically between th...
Longwei Liu,Peixiang He,Yuxuan Wang et al.
Longwei Liu et al.
Chimeric antigen receptor (CAR) T cell therapy for solid tumors encounters challenges such as on-target off-tumor toxicity, exhaustion, and limited T cell persistence. Here, we engineer sonogenetic EchoBack-CAR T cells using an ultrasensiti...
Optimizing stem cell infusion timing in the prevention of acute graft-versus-host disease [0.03%]
优化干细胞输注时间以预防急性的移植物抗宿主病
Yiwen Hou,Yue Wu,Yang Cao et al.
Yiwen Hou et al.
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a cornerstone treatment for a broad spectrum of malignant and nonmalignant hematological disorders. However, the success of allo-HSCT is often overshadowed by acute graft-ver...