Adrenergic control of immune and metabolic responses in bivalve hemocytes: evidence from Mytilus galloprovincialis [0.03%]
地中海贻贝壳细胞中肾上腺素对免疫和代谢反应的调节作用：来源于Mediterranean mussel Mytilus galloprovincialis的证据
A A Tkachuk,T A Kukhareva,A Yu Andreyeva
A A Tkachuk
Catecholamines (CAs) play a central role in the neuroendocrine regulation of immune functions in bivalve mollusks under acute stress. However, the precise effects of different CAs-adrenaline, noradrenaline, and dopamine-on hemocyte immune p...
MDA5 associates with MAVS and its splicing variant in the antiviral response of large yellow croaker Larimichthys crocea [0.03%]
大黄鱼(Megapercia crocea)的天然抗病毒免疫反应中，MDA5与MAVS及其剪接变体的相互作用研究
Ying Li,Yi Fan Zhang,Xia Ming Chen et al.
Ying Li et al.
As an essential intracellular sensor of the RLR family, MDA5 recognizes viral dsRNA and triggers host antiviral immune responses. In this study, we cloned and characterized the MDA5 homolog from large yellow croaker (Larimichthys crocea), n...
NEW VACCINE STRATEGIES TARGETING CELLULAR AND TRAINED IMMUNITY AGAINST INTRACELLULAR BACTERIA IN FISH [0.03%]
针对鱼类胞内细菌的细胞免疫和训练免疫的新疫苗策略
Esteban A Valdebenito,Susan M Bueno,Pablo A González et al.
Esteban A Valdebenito et al.
The rapid growth of global aquaculture has led to an increase in infectious diseases, including intracellular bacterial pathogens such as Piscirickettsia salmonis and Edwardsiella spp., which threaten the industry's sustainability. These mi...
PmFREP1 exhibits antibacterial activity and bacterial agglutination in Pinctada fucata martensii [0.03%]
珍珠马氏珠母贝PmFREP1的抗菌及细菌凝集作用
Qiyuan Zhang,Chuanjie Liu,Haiying Liang et al.
Qiyuan Zhang et al.
Pinctada fucata martensii is one of the principal shellfish species used for marine pearl cultivation in China and holds considerable economic value. However, increasing pollution in mariculture environments has heightened its susceptibilit...
The critical x[I/L]xbS motif in adaptor proteins, MAVS, MITA, and TRIF contributes to type I IFN production and antiviral immune response in fish [0.03%]
适应蛋白、MAVS、MITA和TRIF中的关键x[I/L]xbS基序有助于鱼类I型干扰素的产生及抗病毒免疫应答
Xue Yun Peng,Jing Hou,Bo Li et al.
Xue Yun Peng et al.
Mammalian antiviral signaling adaptors, such as MAVS, MITA, and TRIF, have been shown to possess a conserved pLxIS motif (p, hydrophilic residue; L, leucine; x, any residue; I, isoleucine; S, serine, phosphorylation site), which has been id...
PoGPx-7, a glutathione peroxidase homolog from teleosts, exhibits bactericidal activity and activates host immune cells against bacterial infection [0.03%]
来源于硬骨鱼的PoGPx-7具有杀菌活性并可在细菌感染中激活宿主免疫细胞
Xin-Yi Jiang,Xue-Pin Han,Jia-Hang Zhang et al.
Xin-Yi Jiang et al.
In mammals, glutathione peroxidase 7 (GPx-7) is a member of the GPx family that exhibits peroxidase activity. Its immunological functions, especially in host defense against bacterial infection, remain unexplored in lower vertebrates. In th...
Modified β-glucans promote saponin and fucosylated chondroitin sulfate biosynthesis in sea cucumber Apostichopus japonicus in association with activation of the TLR-MAPK signaling pathway [0.03%]
β-葡聚糖通过激活TLR-MAPK信号通路促进刺参皂苷和岩藻糖基硫酸软骨素生物合成
Zezheng Qi,Zeyu Zhang,Wenyue Dai et al.
Zezheng Qi et al.
Sea cucumber is a high-value marine food that contains characteristic bioactive components, notably saponins and polysaccharides. Strategies promoting their biosynthesis to improve sea cucumber quality are vital for the industry. The impact...
Molecular Characterization and Preliminary Functional Analysis of the NLRP3 Inflammasome in Golden Pompano (Trachinotus ovatus) in Response to Streptococcus agalactiae Infection [0.03%]
金线鱼（Trachinotus ovatus）NLRP3炎性小体的分子特征及对GBS感染响应的功能初探
Zhengjing Lin,Xuemei Mou,Peng Xu et al.
Zhengjing Lin et al.
Golden pompano (Trachinotus ovatus) is an economically important marine fish in southern China, but intensive aquaculture has increased the risk of bacterial diseases, especially streptococcosis caused by Streptococcus agalactiae. As a key ...
Largemouth bass virus infection subverts immune-redox homeostasis in zebrafish and is associated with coordinated suppression of NF-κB and Nrf2 signaling [0.03%]
大口病毒感染破坏斑马鱼的免疫氧化还原稳态并伴有NF-κB和Nrf2信号的协同抑制现象
Lingfeng Guan,Xinyue Zhang,Ting Yu et al.
Lingfeng Guan et al.
From lower vertebrates to higher mammals, oxidative stress and inflammatory responses form a tightly regulated homeostatic network, yet the virus-specific mechanisms that coordinate these processes remain unclear. Here, we investigated this...
LitCTL1: A novel C-type lectin involved in the mucosal and cellular immunity of the common periwinkle Littorinalittorea [0.03%]
LitCTL1：一种新型C型凝集素，参与滩栖腹足动物波氏林螺（Littorina littorea）粘膜和细胞免疫作用
Alexander M Gorbushin,Elena A Borisova
Alexander M Gorbushin
C-type lectins (CTLs) are vital pattern-recognition receptors (PRRs) that mediate innate immune responses in mollusks, yet their characterization in Caenogastropoda, the largest gastropod group, remains limited. This study characterizes Lit...