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MDA5 associates with MAVS and its splicing variant in the antiviral response of large yellow croaker Larimichthys crocea

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As an essential intracellular sensor of the RLR family, MDA5 recognizes viral dsRNA and triggers host antiviral immune responses. In this study, we cloned and characterized the MDA5 homolog from large yellow croaker (Larimichthys crocea), named Lc-MDA5. The co... ...