Multimodular Metabolic Engineering Strategy Enables High-Efficiency Synthesis of Lacto- N-fucopentaose I in Engineered Escherichia coli [0.03%]
多模块代谢工程策略促进乳二糖岩藻五糖I在大肠杆菌中的高效合成
Jin Wang,Caiwen Lao,Jinyong Wu et al.
Jin Wang et al.
Lacto-N-fucopentaose I (LNFP I), a fucosylated neutral human milk oligosaccharide (HMO) with diverse biological functions, was biosynthesized through metabolic engineering in Escherichia coli BL21star (DE3).
Unlocking the potential of flavonoid biosynthesis through integrated metabolic engineering [0.03%]
集成代谢工程解锁黄酮类化合物生物合成潜力
Yuan Wang,Jiahong Chen,Genhe He et al.
Yuan Wang et al.
Distinct from conventional reviews, this review explores how plant cell factories, genome editing, environmental optimization, and artificial intelligence (AI)-driven metabolic engineering can be integrated to boost flavonoid production.
LcMYB46, a R2R3-MYB Transcription Factor, Promotes the Accumulation of Citral by Activating TPS-CYP Cascade in Litsea cubeba [0.03%]
Litsea cubeba中R2R3-MYB转录因子LcMYB46通过激活TPS-CYP途径促进香茅醇积累
Jiahui Yang,Yicun Chen,Ming Gao et al.
Jiahui Yang et al.
Our research has constructed a regulatory network for citral synthesis centered on the TPS28-CYP94A1 cascade and offers novel genetic resources for metabolic engineering to enhance citral yield in plants.
Establishing Halomonas as a chassis for industrial biotechnology: advances in synthetic biology tool development and metabolic engineering strategies [0.03%]
建立海洋弧菌作为工业生物技术底盘的构想：合成生物学工具开发和代谢工程策略的进展
André A B Coimbra,Satya Prakash,José I Jiménez et al.
André A B Coimbra et al.
Conclusion: Recent developments in synthetic biology tools and metabolic engineering highlighted in this review underscore the potential of Halomonas for large scale metabolite production and provide a promising outlook towards their role as a microbial chassis in industrial biotechnology
Systems-level analysis provides insights on methanol-based production of l-glutamate and its decarboxylation product γ-aminobutyric acid by Bacillus methanolicus [0.03%]
系统分析为甲醇基棒状芽孢杆菌生产L-谷氨酸及其脱羧产物γ-氨基丁酸提供见解
Marta Irla,Ingemar Nærdal,David Virant et al.
Marta Irla et al.
To showcase the potential of this mutant strain, further metabolic engineering enabled the production of γ-aminobutyric acid (GABA) directly from l-glutamate during methanol fed-batch fermentations....These results and insights provide a foundation for further rational metabolic engineering and bioprocess optimization, enhancing the industrial viability of B. methanolicus for sustainable production of l-glutamate and its derivatives.
Metabolic Engineering in Hot Acid: Strategies Enabling Chemolithotrophy in Thermoacidophilic Archaea [0.03%]
极端条件下的代谢工程：在热酸性古菌中实现无机营养的策略
Daniel J Willard,Robert M Kelly
Daniel J Willard
A genome-scale metabolic model was developed to explore metabolic engineering strategies for thermoacidophilic archaea, with a focus on the genetically tractable Sulfolobus acidocaldarius (Topt 75 °C, pHopt 2.5)....Previous metabolic engineering efforts enabled sulfur oxidation by S. acidocaldarius, albeit at levels below native sulfur oxidizers. Model analysis pointed to active sulfur transport as a key missing complement to passive diffusion....The findings here provide new insights into the basis for thermoacidophile chemolithotrophy and motivate further efforts to develop S. acidocaldarius into a valuable metabolic engineering platform.
Insights into genetic determinants of volatile fatty acid catabolism in Cupriavidus necator H16 [0.03%]
铜绿假单胞菌H16挥发性脂肪酸降解的遗传决定因子研究
Eric C Holmes,Stephanie L Breunig,Christopher W Johnson et al.
Eric C Holmes et al.
A more complete understanding of the regulatory and biochemical mechanisms that bacteria use to respond to and catabolize waste-derived carbon resources will enable metabolic engineering strategies to improve bioconversion of these same resources.
Xiu Zang,Yankun Yang,Chunjun Zhan et al.
Xiu Zang et al.
This article delves into the detailed examination of methanol metabolic pathways (including formaldehyde and formate) and provides an overview of recent progress in metabolic engineering for synthetic methylotrophic microorganisms.
Engineering of xylose metabolic pathways in Rhodotorula toruloides for sustainable biomanufacturing [0.03%]
工程改造解脂耶氏酵母木糖代谢途径用于可持续生物制造
Hyunjoon Oh,Hyun Gi Koh,Suk-Chae Jung et al.
Hyunjoon Oh et al.
These findings highlight the fundamental differences between R. toruloides xylose metabolism and the oxidoreductase pathways observed in other xylose-fermenting yeast, providing insights for metabolic engineering strategies to improve xylose utilization and enhance bioconversion of cellulosic hydrolysates
Rosmarinic Acid as Bioactive Compound: Molecular and Physiological Aspects of Biosynthesis with Future Perspectives [0.03%]
岩藻糖作为生物活性化合物的分子和生理方面的影响及未来前景展望
Dragana Jakovljević,Marzena Warchoł,Edyta Skrzypek
Dragana Jakovljević
Recent progress in synthetic biology-based RA synthesis, as well as metabolic engineering techniques to enhance the industrial production of this valuable bioactive constituent, are also discussed.
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