How influenza A virus NS1 impedes transcription of the host cell's messenger RNAs [0.03%]
流感病毒A型NS1蛋白抑制宿主细胞信使核糖核酸的转录机制研究
Daniel Marc
Daniel Marc
How influenza virus non-structural protein NS1 inhibits the activity of nuclear speckles, these liquid-liquid phase separation complexes that control the transcription and post-transcriptional regulation of cellular genes.
Highly pathogenic avian influenza H5N1 in the United States: recent incursions and spillover to cattle [0.03%]
高致病性禽流感H5N1病毒在美国的近几次入侵及跨物种感染至牛群
Ahmed Mostafa,Aitor Nogales,Luis Martinez-Sobrido
Ahmed Mostafa
Since Spring 2024, new genotypes of highly pathogenic avian influenza (HPAI) H5N1 clade 2.3.4.4b have been identified in the United States (US). These HPAI H5N1 genotypes have caused unprecedented multi-state outbreaks in poultry and dairy ...
Exploring the role of infected keratinocytes during rabies virus infection [0.03%]
探讨狂犬病病毒感染过程中感染角质形成细胞的作用
Keshia Kroh,Redwan Rahmat,Lineke Begeman et al.
Keshia Kroh et al.
Rabies virus (RABV), a lyssavirus causing fatal encephalitis, is primarily transmitted via dog bites, though superficial exposures such as scratches or bat bites can also result in infection. The mechanisms underlying transmission through t...
HSV1 glycoprotein D utilizes an LY6-like binding domain to inhibit alpha7 nicotinic receptors [0.03%]
HSV-1糖蛋白D利用LY6样结合结构域抑制α7烟碱型乙酰胆碱受体
Sabina Yeasmin,Kavita Sharma,Christopher Nicolet et al.
Sabina Yeasmin et al.
Herpes virus1(HSV1) is a neurotropic virus that has been linked to Alzheimer's disease. An In-silico structural homology search using α -Bgtx, identified structural homology between HSV1 gD and the nicotinic receptor neurotoxin α-Bgtx. SP...
Longitudinal kinetics of the viral infection biomarker 3'-deoxy-3',4'-didehydro-cytidine in SARS-CoV-2, influenza A virus and RSV human challenge models [0.03%]
SARS-CoV-2、流感A病毒和RSV人体攻毒模型中病毒感染生物标志物3'-脱氧-3',4'-二氢基胞苷的纵向动力学研究
Ravi Mehta,Elena Chekmeneva,Stephanie Ascough et al.
Ravi Mehta et al.
3'-deoxy-3',4'-didehydro-cytidine (ddhC) is a recently discovered host biomarker for viral infections, though its temporal kinetics remain unclear. This study tests the hypothesis that ddhC is an acute phase reactant, rising shortly after v...
Experimental Usutu virus infection in Eurasian blackbirds (Turdus merula) [0.03%]
乌苏图病毒在欧亚黑鸟（Turdus merula）身上的实验性感染研究
Gianfilippo Agliani,Imke Visser,Eleanor M Marshall et al.
Gianfilippo Agliani et al.
Usutu virus (USUV) is a zoonotic arbovirus causing disease in wild birds and humans. Eurasian blackbirds (Turdus merula) are highly susceptible to infection, developing severe lesions with high mortality rates during outbreaks. The pathogen...
Differential patterns of cross-protection against antigenically distinct variants in small animal models of SARS-CoV-2 infection [0.03%]
小动物模型中针对抗原不同变体交叉保护的差异模式
Prabhuanand Selvaraj,Charles B Stauft,Shufeng Liu et al.
Prabhuanand Selvaraj et al.
Continuous evolution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) will likely necessitate periodic updates of vaccine composition. Based on a series of studies carried out in human ACE2 transgenic mice (K18-hACE2) and Syr...
Ultrastructural and transcriptional changes during a giant virus infection of a green alga [0.03%]
巨噬细胞感染绿色藻类的超微结构和转录变化
Andrian P Gajigan,Christopher R Schvarcz,Cecilia Conaco et al.
Andrian P Gajigan et al.
The genome of Oceanusvirus kaneohense isolate, Tetraselmis virus 1 (TetV-1), was previously sequenced, but little was known about its infection cycle. We determined the eclipse period (4-8 h), latent period (16 h), and burst size (~1000), a...
Jônatas Santos Abrahão
Jônatas Santos Abrahão
Giant viruses are a complex and diverse group infecting organisms from unicellular eukaryotes to animals. From the characterization of novel viruses to the development of advanced bioinformatic tools for taxonomy and classification, these c...
Influenza A virus NS1 suppresses nuclear speckles promoted gene expression by inhibition of transcription [0.03%]
流感病毒NS1通过抑制转录来抑制细胞核speckles的基因表达
Wolfgang Nacken,Juliane Mayr,André Schreiber et al.
Wolfgang Nacken et al.
IAV-NS1 proteins that interact with Cleavage and polyadenylation specific factor 30 are known to inhibit host gene expression. Here we report that in both transfection and infection experiments, a strong attenuation of reporter gene express...