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Differential patterns of cross-protection against antigenically distinct variants in small animal models of SARS-CoV-2 infection

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Continuous evolution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) will likely necessitate periodic updates of vaccine composition. Based on a series of studies carried out in human ACE2 transgenic mice (K18-hACE2) and Syrian hamsters, we sho... ...