Mn-MIL-100@AKG alleviates intervertebral disc degeneration by regulating mitophagy [0.03%]
Mn-MIL-100@AKG通过调节线粒体自噬缓解椎间盘退变
Xianglong Chen,Haiyang Gao,Anran Zhang et al.
Xianglong Chen et al.
Currently, the therapy of intervertebral disc degeneration (IDD) mostly focuses on basic molecular causes. Research on the alterations of metabolites in the intervertebral disc prior to and following intervertebral disc degeneration (IDD) r...
Selenium nanoparticles alleviate cobalt toxicity in artificial joint metal prostheses by inhibiting ferroptosis through activation of the PRDX6/GPX4 pathway [0.03%]
硒纳米颗粒通过激活PRDX6/GPX4通路抑制铁死亡从而缓解人工关节金属假体的钴毒性
Pengcheng Xu,Fan Liu,Su Jiang et al.
Pengcheng Xu et al.
The long-term implantation of metallic joint prostheses results in the release of cobalt nanoparticles (CoNPs), leading to local and even systemic toxic reactions that pose risks to patient health. Previous studies have suggested that CoNPs...
Functional scaffolds design strategies for retinal repair and regeneration [0.03%]
视网膜修复和再生的功能性支架设计策略
Pei Lin Chee,Ming Hao,Gaodan Liu et al.
Pei Lin Chee et al.
The growing strain placed on both society and the healthcare system due to an ageing population should not be underestimated. Age-related macular degeneration (AMD) is a leading cause of blindness worldwide and is projected to affect 288 mi...
Muscle homing peptide modified liposomes loaded with EGCG improved skeletal muscle dysfunction by inhibiting inflammation in aging mice [0.03%]
肌龄化小鼠肌肉功能障碍的EGCG脂质体载体干预及作用机制研究
Zongyu Huang,Jianjie Xie,Nana Gao et al.
Zongyu Huang et al.
Skeletal muscle aging frequently leads to a reduction in muscle mass and strength, significantly compromising the quality of life in elderly individuals. Skeletal muscle dysfunction during aging is widely recognized to be closely linked to ...
Myosin-actin pattern links matrix stiffness to GFAT2-hyaluronan metabolism [0.03%]
肌动蛋白模式连接基质硬度和GFAT2-透明质酸代谢
Yuwei Zhou,Yifei Zheng,Biao Sheng et al.
Yuwei Zhou et al.
While dysregulated extracellular matrix deposition and stiffening are known to drive tumor progression, breast cancer cells can persist, relapse, and metastasize to soft microenvironments. The distinct strategies that tumor cells adapted to...
Ceria nanoparticles guard against glucocorticoid induced bone homeostasis imbalance through the promotion of osteogenesis and inhibition of osteoclastogenesis [0.03%]
纳米氧化铈通过促进成骨和抑制破骨防治糖皮质激素诱导的骨稳态失衡
Anwei Zhang,Zhiwei Liu,Ling Zou et al.
Anwei Zhang et al.
Osteoporosis induced by the long-term administration of glucocorticoids is a common clinical problem. Current anti-osteoporosis therapies mainly focus on bone resorption inhibition or bone formation promotion unilaterally. However, the imba...
Ultrasound-activated piezoelectric scaffolds target dual Ca2+/NF-κB signaling pathways to orchestrate immunomodulation and osteogenesis for accelerated bone regeneration [0.03%]
超声激活压电支架靶向双钙离子/NF-κB信号通路以调节免疫并促进成骨以加速骨再生
Hui Zheng,Pengfei Yan,Peng Liu et al.
Hui Zheng et al.
Critical-sized bone defects fail to heal due to dysregulated inflammation and impaired osteogenesis. To overcome the limitations of static biomaterials, we engineered 3D-printed polycaprolactone scaffolds incorporating polydopamine coated B...
Epileptogenic zone-targeting nanoparticle drug delivery system for antiseizure medication [0.03%]
抗癫痫药物的癫痫发生区靶向纳米载药系统
Honglu Ping,Qi Zhang,Xiaojie Chen et al.
Honglu Ping et al.
Epilepsy is a chronic neurological disorder affecting over 65 million people worldwide, characterized by abnormal excessive excitation of neuronal networks. Traditional antiseizure medications (ASMs), such as phenytoin (PHT), have limited t...
An injectable phosphocreatine-grafted hydrogel incorporating hierarchically structured teriparatide/SrZnP-functionalized Zn-Cu particles for osteogenesis-angiogenesis coupling and osteoporotic bone regeneration [0.03%]
一种可注射的磷 creatine-接枝的水凝胶，其中包含分级结构的泰瑞派肽 / SrZnP 功能化的 Zn-Cu 粒子，用于成骨 - 血管生成偶联和骨质疏松性骨再生
Haotian Qin,Zhiping Guan,Yuanhao Wang et al.
Haotian Qin et al.
Osteoporotic bone defects remain a major clinical challenge due to impaired osteogenesis, insufficient angiogenesis, excessive osteoclast activity, and increased susceptibility to infection. To address these issues, we developed an injectab...
Reshaping tumor immune microenvironment through ROS-responsive prodrug polyplexes via synergistic effect of CRISPRi system and epigenetic inhibitor for breast cancer therapy [0.03%]
通过CRISPR干扰系统和表观遗传抑制剂的协同作用利用ROS响应前药聚复合物重塑肿瘤免疫微环境用于乳腺癌治疗
Huan Deng,Qianru Li,Bingxu Wang et al.
Huan Deng et al.
Engagement of programmed death-ligand 1 (PD-L1) on tumor cells with its receptor PD-1 on immune cells can transmit an inhibitory signal to induce immune evasion. Although the immune checkpoint inhibitor PD-L1 antibody has shown antitumor ca...