A bioprinted animal patient-derived breast cancer model for anti-cancer drug screening [0.03%]
基于生物打印的动物源性乳腺癌药物筛选模型
Xuan Mei,Maria Fernanda Uribe Estrada,Muhammad Rizwan et al.
Xuan Mei et al.
Animal models are commonly used for drug screening before clinical trials. However, developing these models is time-consuming, and the results obtained from these models may differ from clinical outcomes due to the differences between anima...
Electrostimulation combined with biodegradable electroactive oriented nanofiber polycaprolactone/gelatin/carbon nanotube to accelerate wound healing [0.03%]
用于加速伤口愈合的电刺激与可生物降解的电活性定向纳米纤维聚己内酯/明胶/碳纳米管的联合使用
Weizhi Chen,Yiliu Wei,Jing Chang et al.
Weizhi Chen et al.
Wound healing is a complex but precise physiological process. Howener, existing treatments are often difficult to meet the needs of different wound healing. With the background that exogenous electrical stimulation (ES) has been proven to b...
One-step fabrication of 3D-aligned human skeletal muscle tissue and measurement of contractile force for preclinical drug testing [0.03%]
一步法制造用于药物测试的三维排列的人体骨骼肌组织及其收缩力检测
Azumi Yoshida,Kazuki Baba,Hironobu Takahashi et al.
Azumi Yoshida et al.
Human muscle tissue models are critical to understanding the complex physiology of skeletal muscle in studies of drug discovery, development, and toxicity profiling in the human body. However, due to the challenges in in vitro maturation of...
In-vivo and ex-vivo evaluation of bio-inspired structures fabricated via PBF-LB for biomedical applications [0.03%]
基于PBF-LB的仿生结构生物医学应用的体内和体外评价
Miguel Araya,Antti Järvenpää,Timo Rautio et al.
Miguel Araya et al.
Titanium-based lattice structures have gained significant attention in biomedical engineering due to their potential to mimic bone-like behavior and improve implant performance. This study evaluates the performance of bio-inspired Ti64 TPMS...
Crosslinker-free in situ hydrogel induces self-aggregation of human dental pulp stem cells with enhanced antibacterial activity [0.03%]
无需交联剂的原位水凝胶增强人牙髓干细胞自聚集及抗菌活性
Sang Jin Lee,Zhenzhen Wu,Mengyu Huang et al.
Sang Jin Lee et al.
Recently, injectable hydrogels have garnered significant attention in tissue engineering due to their controlled flowability, strong plasticity, adaptability, and good biocompatibility. However, research on readily injectable in situ-formin...
Fucoidan alginate and sulfated alginate microbeads induce distinct coagulation, inflammatory and fibrotic responses [0.03%]
硫酸化海藻酸盐微球诱导不同的凝血、炎症和纤维化反应
Kalaiyarasi Vasuthas,Joachim Sebastian Kjesbu,Alessandro Brambilla et al.
Kalaiyarasi Vasuthas et al.
This study investigates the host response to fucoidan alginate microbeads in comparison to sulfated alginate microbeads, which are relevant for immune protection in cell therapy. While sulfated alginate microbeads reduce fibrosis and inflam...
Natural polymer based drug-loaded hydrogel platform for comprehensive care of acute spinal cord injury [0.03%]
基于天然多聚物的药物载入水凝胶平台在急性脊髓损伤全面治疗中的应用
Mingyu Zhang,Chunyu Xiang,Xin Zhen et al.
Mingyu Zhang et al.
Traumatic spinal cord injury typically occurs at significant depths and triggers rapid and severe physiological responses. It is commonly accompanied by oxidative stress disorders, lipid peroxidation, accumulation of toxic aldehydes, and ed...
Bivalirudin functionalized hydrogel coating capable of catalytical NO-generation for enhanced anticorrosion and biocompatibility of magnesium alloy [0.03%]
一种双嘧达莫功能化水凝胶涂层用于促进镁合金催化型一氧化氮释放、耐蚀及生物相容性的研究
Changjiang Pan,Naiquan Yang,Jie Chen et al.
Changjiang Pan et al.
Magnesium and its alloys are undoubtedly ideal candidates for manufacturing new bioabsorbable vascular stents thanks to their good bio-absorbability and better mechanical characteristics. However, the bottlenecks that restrict their clinica...
Redox-responsive metal-organic framework nanocapsules enhance tumor chemo-immunotherapy by modulating tumor metabolic reprogramming [0.03%]
红氧化响应金属有机骨架纳米胶囊通过调节肿瘤代谢重编程增强肿瘤化疗免疫疗法
Yuman Dong,Jieru Li,Yiwei Dai et al.
Yuman Dong et al.
Immunotherapy, particularly immune checkpoint blockade (ICB), has opened the era of modern oncology, offering significant promise for modern oncology. However, the efficacy of immunotherapy is frequently curtailed by the immunosuppressive t...
Glioblastoma drives protease-independent extracellular matrix invasion of microglia [0.03%]
胶质母细胞瘤驱动基质金属蛋白酶非依赖性的星形胶质细胞外基质侵袭
Chia-Wen Chang,Ashwin Bale,Rohit Bhargava et al.
Chia-Wen Chang et al.
Glioblastoma (GBM) is the most common and lethal form of primary brain cancer. Microglia infiltration into the tumor microenvironment is associated with immunosuppression and poor prognosis. Improved physicochemical understanding of microgl...