Versatile metal-phenolic network structure (MPNs) as advanced delivery platforms for bioactive compounds: The design principles, foundations, applications, and future perspectives [0.03%]
多功能金属酚网络结构（MPN）作为生物活性化合物的高级输送平台：设计原则、基础、应用和未来展望
Yafei Zhang,Zenghui Xia,Yi Xue et al.
Yafei Zhang et al.
Despite possessing many important functions, the applications of bioactive compounds (BCs) are significantly limited due to various inherent shortcomings. In recent years, a novel class of materials known as metal-phenolic network structure...
Programmable continuous gradient bioprinting for engineering spatially heterogeneous microenvironments [0.03%]
可编程连续梯度生物打印技术用于工程构建空间异质性微环境
Taekyung Choi,Hyungseok Lee
Taekyung Choi
Native tissues exhibit spatial heterogeneity in mechanical, cellular, and biochemical properties, yet reproducing such gradients in extrusion-based bioprinting remains challenging. Existing multi-material bioprinting approaches can create s...
Engineering adaptive self-healing biomaterials from jammed microfluidic elastomeric particles [0.03%]
基于微流体交联弹性颗粒的自修复材料的制备及性能研究
Jennifer Kieda,Kaitlyn Ramsay,Richard Jiang et al.
Jennifer Kieda et al.
Biomaterials designed for implantation must accommodate the dynamic mechanical and structural environment of the human body. Yet, current strategies for creating materials capable of adapting their shape post-implantation remain limited. In...
Enzymatically triggered glucose-releasing scaffolds as nutritional supports for millimeter-scale tissue engineering [0.03%]
基于酶触发释糖的营养载体毫米尺寸组织工程
Panitporn Laowpanitchakorn,Marie Piantino,Tomoya Matsuo et al.
Panitporn Laowpanitchakorn et al.
Construction of millimeter-sized tissues to mimic real human tissue or organ is still challenging, as oxygen and nutrients have a diffusion limit of only 100-200 μm from blood vessels. Almost all mammalian cells except red blood cells and ...
Xylem-inspired anisotropic porous silk microneedles enable efficient interstitial fluid sampling for local biomarker and proteomic profiling of skin diseases [0.03%]
受木质部启发的各向异性多孔丝素微针可有效采集间质液，用于皮肤病局部生物标志物和蛋白质组学分析
Jiahui Fu,Zhenni Chen,Xueyu Wen et al.
Jiahui Fu et al.
Chronic inflammatory skin diseases require safe and repeatable access to localized molecular information to enable mechanistic studies and precision management, yet existing sampling methods remain invasive or poorly representative of the s...
Target FADS1-arachidonic acid-ferroptosis axis: A metabolic bridge linking matrix stiffness to PDAC stemness [0.03%]
靶向FADS1-花生四烯酸-铁死亡轴：一个将基质硬度与胰腺癌干细胞特性联系起来的代谢桥梁
Tiancheng Gong,Jiashuai Yan,Hongyu Zhu et al.
Tiancheng Gong et al.
The elevated stiffness of extracellular matrix (ECM), one of the typical physical hallmarks of pancreatic ductal adenocarcinoma (PDAC), which was proved to promote stemness and leads to adverse prognosis. Therefore, to dissect the underlyin...
Synergistic eradication of NDM-1 Klebsiella pneumoniae biofilm infection by a Meropenem/EDTA Co-delivery system based on gelatin microspheres [0.03%]
基于明胶微球的美罗培南/乙二胺四乙酸共递送体系协同 eradicate NDM-1耐药肺炎克雷伯菌生物被膜感染
Zhaoyou Chu,Shu Fang,Wanyue Fu et al.
Zhaoyou Chu et al.
New Delhi metallo-β-lactamase (NDM)-producing drug-resistant bacteria often form stubborn biofilms and cause severe pneumonia, resulting in conventional antibiotic failure. In this study, we developed gelatin-genipin microspheres co-loaded...
Compressive stress-driven mechanosignaling in chondrocytes: From molecular mechanism to scaffold engineering and translational opportunities [0.03%]
压缩应力驱动的软骨细胞机械信号转导：从分子机制到支架工程及转化机遇
Yongbing Mou,Tingting Tian,Peng Wang et al.
Yongbing Mou et al.
Articular cartilage, a unique avascular and low-cell-density connective tissue, relies predominantly on chondrocyte responses to mechanical cues for the maintenance of tissue homeostasis and functional repair. Among the diverse mechanical s...
Rational design of immunological programs for functional regenerative niches [0.03%]
功能性再生生态位的免疫程序理性设计
Zhumei Zhuang,Pengming Wang,Yixiao Liu et al.
Zhumei Zhuang et al.
The immune system is a master conductor of tissue repair, yet its therapeutic potential remains underexploited. Moving beyond descriptive biology, we propose 'immunoprogramming' as an active design paradigm that synergistically integrates s...
Perovskite immunoadjuvant: Remodeling the immunosuppressive microenvironment via photothermal catalysis to enhance T-cell recruitment and amplify the immune response [0.03%]
钙钛矿型免疫佐剂：通过光热催化重塑免疫抑制微环境，增强T细胞募集并放大免疫反应
Rui Zhang,Xiang Li,Bingbing Duan et al.
Rui Zhang et al.
Immunotherapeutic efficacy is markedly compromised in "cold" tumors, largely as a consequence of the immunosuppressive milieu within the TME, characterized by hypoxia, a fortified antioxidant defense (e.g., elevated glutathione), and insuff...