Ginsenoside Rh2- functionalized liposomes enhanced BRD4-PROTAC delivery and antitumor efficacy via improved tumor targeting and ECM remodeling [0.03%]
人参皂苷Rh2修饰的脂质体通过改善肿瘤靶向性和细胞外基质重塑来增强BRD4-降解剂的递送和抗肿瘤效果
Lijuan Wen,Jialei Rao,Jiaoting Chen et al.
Lijuan Wen et al.
PROTAC technology leverages the ubiquitin-proteasome system to selectively degrade target proteins, presenting a novel strategy for anticancer therapy. ARV825, a BRD4-targeting PROTAC, exerts potent antitumor effects by degrading BRD4, ther...
Targeted inflammatory microenvironment remodeling and NIR-II photothermal therapy for abdominal aortic aneurysm [0.03%]
靶向炎症微环境重塑和近红外二区光热治疗腹主动脉瘤
Yijun Liu,Peng Qiu,Huifang Hao et al.
Yijun Liu et al.
Abdominal aortic aneurysm (AAA) is a degenerative aortic disease with high rupture-associated mortality. There is no effective medical therapy for early intervention, inflammatory microenvironment remodeling is a crucial therapeutic strateg...
Resveratrol-embedded hollow cerium oxide nanomedicine targeted treat inflammatory bowel disease through ROS clearance, intestinal mucosal immune homeostasis recovery and gut microbiota modulation [0.03%]
通过ROS清除，肠道黏膜免疫稳态恢复和肠道微生物调节针对炎症性肠病的嵌有白藜芦醇的空心氧化铈纳米药物治疗
Tianlin Wang,Xiaoxia Lin,Wenjie Li et al.
Tianlin Wang et al.
Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the gastrointestinal tract that is difficult to cure. The crucial pathogenic factors of IBD are mainly caused by the overexpression of pro-inflammatory cytokines and the...
Ferritin-nanocaged aggregation-induced emission nanoaggregates for integrated sensitive detection and treatment of gastric cancer [0.03%]
铁蛋白纳米笼-聚集诱导发光纳米聚集体用于胃癌的集成检测和治疗
Junjian Deng,Zengxing Zhang,Kejun Li et al.
Junjian Deng et al.
Gastric cancer remains a global health challenge due to late diagnosis and limited targeted therapies. Herein, we report a novel dual-targeted nanoplatform, AIE@HFn-scfv, integrating aggregation-induced emission luminogens (AIEgens) with hu...
Copper/iron-based intelligent nanoparticles self-amplify apoptosis/ferroptosis/cuproptosis in colorectal cancer [0.03%]
基于铜/铁的智能纳米颗粒可在结直肠癌中自增强凋亡/铁死亡/铜死亡
Xuna Xue,Zhibo Zhang,Qiyu Zhang et al.
Xuna Xue et al.
To address the key challenge of insufficient chemosensitivity in colorectal cancer treatment due to apoptosis resistance, this study proposes a "multi-pathway synergistic killing" strategy that enhances anti-tumour efficacy by simultaneousl...
TRIM30a coordinates neutrophil-macrophage crosstalk to resolve inflammation and drive osseointegration via suppressing NETosis/cGAS-STING axis [0.03%]
TRIM30a通过抑制NETosis/cGAS-STING轴协调中性粒细胞-巨噬细胞相互作用以消炎并促进种植体骨结合
Jia Li,Yangbo Xu,Congrui Zhao et al.
Jia Li et al.
The innate immune response to bone biomaterials critically regulates osteogenesis, yet the molecular mechanisms governing neutrophil-macrophage crosstalk remain poorly understood. Building on our discovery of neutrophil involvement in bone ...
Recent advances in biomaterials for bone regeneration: Bridging innovation and clinical translation [0.03%]
用于骨再生的生物材料最新进展：创新与临床转化之间架桥工程
Zahra Sabouri,Mélanie Dequeecker,Houmam Anees et al.
Zahra Sabouri et al.
Bone regeneration presents an enduring clinical barrier, particularly with the projected rise in osteoporotic fractures exceeding 6 million annually by 2050. Autografts, allografts, and xenografts remain foundational in bone repair due to t...
A WR3-NH2-loaded polysaccharide hydrogel with antibacterial, anti-inflammatory, and pro-healing properties for enhanced wound healing [0.03%]
一种具有抗菌、抗炎和促愈合性能的WR3-NH2负载多糖水凝胶促进伤口修复
Zhizhi Chen,Chao Li,Lei Wang et al.
Zhizhi Chen et al.
Wound healing is a complex process often compromised by infection, excessive inflammation, and impaired tissue regeneration. In this study, the antimicrobial peptide WR3-NH2 loaded multifunctional polysaccharide hydrogel (SGHC-WR) was devel...
Design and in vitro validation of Brome mosaic -virus-like particles for gene delivery and immunomodulation of melanoma [0.03%]
用于基因传递和免疫调节的斑皮层病毒样颗粒的设计及体外验证研究
Khalil Elbadri,Manlio Fuscielo,Firas Hamdan et al.
Khalil Elbadri et al.
RNA interference (RNAi) is a powerful tool for post-transcriptional gene silencing, yet its clinical translation remains limited by the lack of safe and efficient delivery systems. In this study, we evaluated the potential of plant virus-li...
Injectable gallic acid-engineered zwitterionic hydrogel for preventing postoperative adhesions in thyroid surgery through modulating oxidative stress and inflammation [0.03%]
通过调节氧化应激和炎症反应用于甲状腺手术防粘连的棓酸工程两性离子水凝胶注射液
Ye Zhu,Mingbo Zhang,Luyao Feng et al.
Ye Zhu et al.
Postoperative adhesions after thyroid surgery pose significant clinical challenges, leading to dysphagia and reoperation risks. Current anti-adhesion barriers are limited by poor anatomical conformity of membranes, short retention time of g...