Mussel-inspired coaxial electrospun nanofiber membranes promote scarless oral mucosal repair by enhancing macrophage M2 polarization [0.03%]
受贻贝启发的同心共纺纳米纤维膜通过增强巨噬细胞M2极化促进无瘢痕口腔粘膜修复
Junpeng Chen,Jinpeng Jiang,Wenyi Shen et al.
Junpeng Chen et al.
The repair of oral mucosal defects is often hindered by the failure of traditional materials to maintain adhesion in humid, dynamic environments. Inspired by the wet-adhesion properties of mussels, we developed a biomimetic self-adhesive na...
Transient blood-brain barrier opening by focused ultrasound enhances ferumoxytol accumulation in glioblastoma [0.03%]
磁聚焦超声技术可使胶质瘤中铁复合物的积聚增多
Giovanni M Saladino,Payton J Martinez,Jie Wang et al.
Giovanni M Saladino et al.
Nanoparticle delivery to glioblastoma is limited by the blood-brain barrier (BBB), which restricts the transport of diagnostic and therapeutic agents into tumor tissue. Microbubble-mediated focused ultrasound (FUS) can transiently increase ...
A "metabolic dual-clamp" strategy for glucose metabolism blockade and cascade-amplified tumor immunotherapy [0.03%]
一种针对葡萄糖代谢阻断和肿瘤免疫治疗的“代谢钳形策略”
Peng Chang,Xiaoyu Yang,Dehong Chen et al.
Peng Chang et al.
Immunogenic cell death (ICD) represents a promising approach to convert "cold tumor" into "hot tumor". However, its induction is often hampered by the immunosuppressive tumor microenvironment fueled by aberrant glucose metabolism. Here, we ...
M Vallet-Regí,J A Planell,D Lozano et al.
M Vallet-Regí et al.
Over the past decades, strategies for skeletal repair have undergone a significant transformation, shifting from inert structural replacements to advanced systems capable of actively promoting bone regeneration. Early biomaterials, includin...
Enhancing anti-fibrotic therapy: nanomedicine approaches to overcome current limitations [0.03%]
增强抗纤维化疗法：纳米药物克服当前局限性的方法
Lincan Wu,Xin Li,Lina Yang
Lincan Wu
Fibrosis, as a shared hallmark, is prevalent in a variety of chronic diseases. However, current pharmacological strategies for fibrosis are limited in clinical application and efficacy due to issues such as insufficient targeting capability...
ROS-responsive nanocarriers for the delivery of atorvastatin in ischemic MCAO rats promoting neuroprotection [0.03%]
响应ROS的纳米载体在缺血性MCAO大鼠中递送阿托伐他汀以促进神经保护作用
Raveena Nagareddy,Aravindkumar Sundaram,Ja-Hae Kim et al.
Raveena Nagareddy et al.
Ischemic stroke remains a major global public health burden, ranking among the leading causes of long-term neurological disability and mortality. Despite advances in acute care, drug delivery to injured brain tissue is hindered by the poor ...
Leveraging antisolvent-processed β-sitosterol to construct a multifunctional curcumin-loaded oleogel for diabetic wound healing [0.03%]
利用抗溶剂处理的β-谷固醇构建多功能姜黄素载药油凝胶用于糖尿病伤口修复
Hongyang Guo,Shulin Deng,Caihuan Huang et al.
Hongyang Guo et al.
The complex microenvironment of diabetic wounds is the primary cause of slow wound healing, manifesting as a vicious cycle of excessive reactive oxygen species (ROS) accumulation and overexpression of inflammatory factors. Regulating this m...
Magnetic hydrogel-mediated periodic stimulation enhances mesenchymal stem cell small extracellular vesicle release [0.03%]
磁性水凝胶介导的周期性刺激可增强间充质干细胞来源的小细胞外囊泡释放
Chen Wang,Ye Chen,Tianhao Yan et al.
Chen Wang et al.
Small extracellular vesicles (sEVs) derived from mesenchymal stem cells (MSCs) are regarded as important "cell-free" therapeutic carriers due to their potential for immune regulation and tissue repair. However, their large-scale application...
All-in-one nerve guidance: transplanting a gradient scaffold with immobilized Schwann cells for peripheral nerve regeneration [0.03%]
具备施万细胞的梯度支架移植的一体化神经导管促进周围神经再生
Shengwen Zhu,Rui Cui,Shuai Qiu et al.
Shengwen Zhu et al.
Peripheral nerve injury (PNI), especially those with long-distance transected defects, remains a major clinical challenge due to limited regenerative capacity associated with inadequate endogenous Schwann cell (SC) support. Here, we develop...
Co-delivery of endoplasmic reticulum-targeted photosensitizer and Ido-1 inhibitor potentiates immunotherapeutic efficacy in triple-negative breast cancer [0.03%]
靶向内质网的光敏剂与IDO-1抑制剂联合递送可增强三阴性乳腺癌免疫治疗效果
Jia Wang,Fengling Wang,Qiang Zhou et al.
Jia Wang et al.
Triple-negative breast cancer (TNBC) generally has a poor response to immunotherapy due to low immunogenicity and an immunosuppressive tumor microenvironment. To address this, a multifunctional nanoparticle, TPI@RPB, was constructed with RG...