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Target FADS1-arachidonic acid-ferroptosis axis: A metabolic bridge linking matrix stiffness to PDAC stemness

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The elevated stiffness of extracellular matrix (ECM), one of the typical physical hallmarks of pancreatic ductal adenocarcinoma (PDAC), which was proved to promote stemness and leads to adverse prognosis. Therefore, to dissect the underlying mechanisms between... ...