Anti-IgLON5 encephalitis is associated with anti-retinal immunological reactivity without retinal alteration [0.03%]
抗IgLON5脑炎与无视网膜病理改变的抗视网膜免疫反应相关
Marie Rafiq,Fanny Varenne,Jérémie Pariente et al.
Marie Rafiq et al.
Anti-IgLON5 disease is a recently defined autoimmune disorder of the central nervous system associated with autoantibodies against IgLON5. This progressive condition, combining features of autoimmunity and neurodegeneration, presents with h...
Long-term natural history of thyroid peroxidase antibodies in a population-based cohort: Findings from 18 years of follow-up in Tehran Thyroid Study (TTS) [0.03%]
德黑兰甲状腺研究中人群基于队列的桥本甲状腺炎自身抗体长期自然病史：18年随访结果
Mohamadamin Tarighat-Payma,Ladan Mehran,Safdar Masoumi et al.
Mohamadamin Tarighat-Payma et al.
Background: Thyroid peroxidase antibody (TPOAb) is considered a highly sensitive marker of autoimmune thyroid diseases (AITD). Limited longitudinal data exist regarding its long-term natural history in the general populat...
Extracellular vesicles and their role in Lupus Nephritis: A scoping review [0.03%]
细胞外囊泡及其在狼疮性肾炎中的作用：系统综述
Lady J Rios-Serna,María Del Mar Rojas-Pelaez,Mildrey Mosquera Escudero et al.
Lady J Rios-Serna et al.
Lupus nephritis (LN) is one of the most severe and common complications of systemic lupus erythematosus (SLE), which pathogenesis is mainly driven by immune complex deposition and infiltration of immune cells, ultimately leading to progress...
Biopsy-proven myocarditis: peripheral immunophenotypes correlate with histology, etiology, immunosuppressive therapy [0.03%]
病理证实的心肌炎：外周免疫表型与组织学、病因及免疫治疗相关性
Cristina Vicenzetto,Andrea Silvio Giordani,Anna Baritussio et al.
Cristina Vicenzetto et al.
Background: Myocarditis is an inflammatory disease of the myocardium with infectious or immune-mediated/autoimmune etiology; etiology diagnosis relays on endomyocardial biopsy (EMB). High titre serum anti-heart autoantibo...
Type I interferon-dependent and -independent signaling underlie autoantibody production in a murine lupus model [0.03%]
I型干扰素依赖和非依赖信号转导参与小鼠狼疮模型自身抗体的产生
Jerrold S Levine,Céleste Pilon,Rebecca Subang et al.
Jerrold S Levine et al.
Systemic lupus erythematosus (SLE) is characterized by the development of autoantibodies against diverse self-antigens and damage to multiple organs. Immunization with the SLE autoantigen β2-glycoprotein I and lipopolysaccharide (LPS) indu...
How loss-of-function mutations in IFIH1 contribute to infectious and/or inflammatory disease - a systematic review [0.03%]
IFIH1失活突变体对感染和/或炎症疾病影响的系统性综述研究
Isabelle Ince,Francesca Sposito,Amandine Charras et al.
Isabelle Ince et al.
The IFIH1 gene encodes for the cytoplasmic innate immune receptor Melanoma Differentiation-Associated protein 5 (MDA5) that detects viral double-stranded RNA to initiate type I interferon (IFN) responses. While gain-of-function mutations in...
Antinuclear antibody targets in autoimmune hepatitis and drug-induced liver injury: Diagnostic relevance of nucleosome antibodies [0.03%]
自身免疫性肝炎和药物性肝损伤中的抗核抗体靶点及组蛋白-小体抗体的诊断意义
Mirjam Kolev,Michèle Freiburghaus,Guido Stirnimann et al.
Mirjam Kolev et al.
Background & aims: Anti-nuclear antibodies (ANA) are detected in 70-100 % of patients with autoimmune hepatitis (AIH) and in 22-33 % of patients with drug-induced liver injury (DILI). However, little is known about the sp...
Female cancer incidence before and after diagnosis of primary Sjögren's disease: A retrospective cohort study [0.03%]
原发性舍格伦综合征诊断前后女性癌症发病率：一项回顾性队列研究
Bitte Sjöström,Anders Bredberg,Peter Olsson et al.
Bitte Sjöström et al.
In primary Sjögren's disease (pSjD), there is a well-documented increased risk of hematological malignancies, particularly lymphomas, whereas studies examining the incidence of solid tumors have often yielded conflicting results. Data conc...
Liraglutide prevents lupus-associated diffuse alveolar hemorrhage via inhibiting lymphocyte infiltration and promoting macrophage M2 polarization [0.03%]
利拉鲁肽通过抑制淋巴细胞浸润和促进巨噬细胞M2极化来预防系统性红斑狼疮相关弥漫性肺泡出血
Li Jiang,Liting He,Duo Li et al.
Li Jiang et al.
Objectives: This study aimed to explore the prophylactic and therapeutic role of liraglutide for lupus-associated diffuse alveolar hemorrhage (DAH). Metho...
Downregulated ECHS1 and HADH-mediated fatty acid β-oxidation contributes to mitochondrial dysfunction in salivary glands of Sjögren's syndrome [0.03%]
腮腺ECHS1和HADH介导的脂肪酸β氧化下调导致舍格伦综合征线粒体功能障碍
Min Zhou,Yu Liu,Jinxia He et al.
Min Zhou et al.
Background: Sjögren's syndrome (SS) is a common autoimmune disease characterized clinically by dry mouth and dry eyes resulting from impaired exocrine gland function. However, its precise pathogenesis remains incompletel...