Rheumatoid factor and anti-citrullinated protein IgA antibodies in the diagnosis, prognosis and monitoring of patients with rheumatoid arthritis [0.03%]
风湿因子和抗瓜氨酸蛋白IgA抗体在类风湿关节炎诊断、预后及监测中的作用
Ulrike Steffen,Daniela Sieghart,Günter Steiner
Ulrike Steffen
Over the past decades immunoglobulin A (IgA) antibodies have gained increasing attention for their diagnostic and prognostic significance in rheumatoid arthritis (RA), complementing the well-established roles of IgM rheumatoid factor (RF) a...
Epidemiological assessment of six major immune-mediated inflammatory diseases based on the Global Burden of Disease Study 2021: analyses of age-standardized incidence, prevalence, mortality, and disability-adjusted life years [0.03%]
基于全球疾病负担研究（2021）的六种主要免疫介导性炎症性疾病流行病学评估：年龄标化发病率、患病率、死亡和伤残调整生命年的分析
Mengyu Huang,Zhaoli Ma,Xiu Luo et al.
Mengyu Huang et al.
Objective: Immune-mediated inflammatory diseases (IMIDs) are a group of chronic conditions characterized by dysregulated immune responses and tissue inflammation, posing a significant challenge to global health. However, ...
Mendelian randomization study of the causal relationship between autoimmune diseases and anemia using proteomic and genetic data [0.03%]
基于蛋白质组学和基因组学数据的自身免疫疾病与贫血因果关系的孟德尔随机化研究
Xin Zhuang,Tianen Pan
Xin Zhuang
Background: Observational studies have suggested a potential association between autoimmune diseases and anemia, but the direction of causality remains unclear. To investigate the potential causal relationship between aut...
Nasser Gholijani,Effat Noori,Zeinab Zarei-Behjani et al.
Nasser Gholijani et al.
Vitiligo is a chronic, acquired skin disorder characterized by the loss of pigmentation due to the destruction or dysfunction of melanocytes. Conventional treatments such as corticosteroids and phototherapy often produce limited and unpredi...
Discovery of a PDE4B and PDE4D selective bifunctional degrader for management of chronic inflammatory disorders [0.03%]
一种选择性靶向PDE4B和PDE4D双功能降解剂的发现用于慢性炎症紊乱的治疗
Arvind Shakya,Qiao Liu,Chon Lai et al.
Arvind Shakya et al.
Atopic dermatitis (AD) is a chronic inflammatory skin disorder characterized by redness and itching, impacting over 15 million individuals in the US. The pathogenesis of AD involves T helper 2 (TH2) and 17 (TH17) cytokines, which contribute...
Divergent trajectories of inflammatory bowel disease in East, South, South-East and Central Asia: A comprehensive GBD 2021 analysis [0.03%]
基于GBD 2021的分析：亚洲各地炎症性肠病的发展轨迹差异较大
Kui Wang,Yunqing Zeng,Shanshan Zhang et al.
Kui Wang et al.
Background: Inflammatory bowel disease (IBD) is no longer confined to Western populations; its burden is rising across Asia, a region with marked demographic, economic, and health-system heterogeneity. Quantifying contemp...
The clinical characteristics and treatment response of myasthenia gravis with positive thyroid peroxidase antibody or thyroid globulin antibody [0.03%]
甲状腺过氧化物酶抗体或甲状腺球蛋白抗体阳性的重症肌无力的临床特征及治疗反应
Hanyu Xin,Mingou Lu
Hanyu Xin
Background and purpose: Myasthenia gravis (MG) frequently associates with thyroid peroxidase antibody (TPOAb) and thyroglobulin antibody (TgAb), indicating shared autoimmunity. This study investigated the impact of TPOAb/...
Identification of key oxidative phosphorylation-related genes in systemic lupus erythematosus based on transcriptomics and bioinformatics analysis [0.03%]
基于转录组学和生物信息学分析识别系统性红斑狼疮中关键的氧化磷酸化相关基因
Shasha Wang,Hongmin Hu,Jingru Chen et al.
Shasha Wang et al.
Objective: Oxidative phosphorylation (OXPHOS) dysfunction is increasingly recognized as a key factor in systemic lupus erythematosus (SLE) pathogenesis. This study aimed to identify OXPHOS-related core genes as potential ...
Novel variants in ARID1B, SPSB1, and RAET1-AS shape genetic susceptibility and protection in systemic lupus erythematosus and lupus nephritis [0.03%]
ARID1B、SPSB1和RAET1-AS的新变异体塑造系统性红斑狼疮和狼疮性肾炎的遗传易感性和保护因素
Hung-Yi Chen,Feng-Cheng Liu,Hsian-Cheng Chen et al.
Hung-Yi Chen et al.
Background: Systemic lupus erythematosus (SLE) is an autoimmune disorder characterized by immune dysregulation affecting multiple organs, most notably lupus nephritis (LN). Genetic susceptibility significantly contributes...
The significance of m6A-circFOXK2 in CD4+T cells from patients with rheumatoid arthritis and circFOXK2 correlates with Th17 % and autophagy [0.03%]
m6A-circFOXK2在类风湿关节炎患者CD4+T细胞中的意义及circFOXK2与Th17%和自噬的相关性研究
Qing Luo,Zhiwei Wu,Qiuyun Xiao et al.
Qing Luo et al.
Objective: CD4+T cells are significant compositions of immune cells in rheumatoid arthritis (RA) and the aberrant function of CD4+T cells have been demonstrated to promote RA's progression. N6-methyladenosine (m6A) is a h...