How loss-of-function mutations in IFIH1 contribute to infectious and/or inflammatory disease - a systematic review
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The IFIH1 gene encodes for the cytoplasmic innate immune receptor Melanoma Differentiation-Associated protein 5 (MDA5) that detects viral double-stranded RNA to initiate type I interferon (IFN) responses. While gain-of-function mutations in IFIH1 have been lin... ...
