Proviral Integration Site for Moloney Murine Leukemia Virus 2 Suppresses Fibronectin 1 to Drive Adhesion Loss and Epithelial-Mesenchymal Transition in Multiple Myeloma [0.03%]
莫诺尼穆勒鼠白血病病毒2型原病毒整合位点通过抑制纤连蛋白1诱导多发性骨髓瘤黏附丧失和上皮间充质转化
Junna Mai,Heng Liang,Arabella H Wan et al.
Junna Mai et al.
Tumor-associated macrophages (TAMs) critically shape the multiple myeloma (MM) microenvironment, yet the molecular programs linking immune signaling to MM dissemination remain unclear. Here, we identify a TAM-derived IL6-STAT3-PIM2-cMyc-FN1...
Navigating Cancer Treatment: A Journey from 2D to 3D Cancer Models and Nanoscale Therapies [0.03%]
癌症治疗导航：从二维到三维肿瘤模型及纳米尺度疗法的旅程
Navneet Kaur,Mary Jean Savitsky,Annie Scutte et al.
Navneet Kaur et al.
Cancer remains one of the most significant global health challenges, characterized by an increasing incidence and mortality rate worldwide. In vitro models play a significant role in the initial investigations of cancer biology, drug screen...
Ultrasensitive Profiling of Arachidonic Acid Metabolites Based on 5‑(Diisopropylamino)amylamine Derivatization-Ultraperformance Liquid Chromatography-Tandem Mass Spectrometry [0.03%]
基于5-(二异丙基氨基)戊胺衍生化-超高效液相色谱-串联质谱的花生四烯酸代谢产物高灵敏分析方法
Peiyan Zheng,Xiaowen Huang,Qing Wang et al.
Peiyan Zheng et al.
Arachidonic acid (AA) and its metabolites play critical roles in inflammation and immune regulation, modulating the initiation, amplification, and resolution of inflammation. However, their comprehensive quantification remains a challenging...
Study on the Effect of Puerarin-Gadolinium on Rheumatoid Arthritis Rats based on Nontargeted Metabolomics Technology [0.03%]
基于非靶向代谢组学技术的刺五加根苷-钆对类风湿关节炎大鼠作用的影响研究
Qing-Qing Ma,Hong-Zhang Cao,Ji-Hai Shi et al.
Qing-Qing Ma et al.
To find potential biomarkers and related metabolic pathways based on metabonomics of rat joint tissue, the rats with stable collagen-induced arthritis (CIA) model were taken as the research object. A rat rheumatoid arthritis model was estab...
Development and Preclinical Evaluation of a Zirconium-89-Labeled Immunoconjugate for Positron Emission Tomography Imaging of Leukemia Inhibitory Factor in Glioblastoma [0.03%]
一种用于成像胶质母细胞瘤中白血病抑制因子的放射性药物89Zr标记免疫缀合物的开发与临床前评估研究
Emily Betancourt Fernández,Julia Baguña Torres,Raffaella Iurlaro et al.
Emily Betancourt Fernández et al.
Leukemia Inhibitory Factor (LIF) is a pleiotropic cytokine secreted by tumor cells to evade immune detection, contributing to tumor progression and resistance to therapy. Targeting LIF has emerged as a promising strategy, with anti-LIF ther...
Affibody-Derived Drug Conjugates Targeting The Epidermal Growth Factor Receptor Are Potent And Specific Cytotoxic Agents [0.03%]
一种针对表皮生长因子受体的 Affibody 衍生药物缀合物共轭物具有强力且特异性的细胞毒性作用
Sara S Rinne,Wen Yin,Ruonan Li et al.
Sara S Rinne et al.
Overactive epidermal growth factor receptor (EGFR) signaling is often involved in driving different types of carcinomas. It is a well-studied target for targeted therapies, with both monoclonal antibodies and kinase inhibitors available for...
Crescent-Shaped Xanthone-Benzimidazole Conjugates as New Target Probes for Telomeric G‑Quadruplex DNA and Specific Cytotoxicity on Cancer Cells [0.03%]
新靶标探针 crescent形番 cherry酸-苯并咪唑共轭物用于端粒G-四联体DNA及对癌细胞的特异性细胞毒性作用研究
Pulakesh Pramanik,Bappa Maiti,Santanu Bhattacharya
Pulakesh Pramanik
Xanthone, an oxygenated heterotricyclic phytochemical, has recently emerged as a promising scaffold in cancer research due to its multitargeted anticancer potential. Recent studies demonstrate its affinity for G-quadruplex (G4) DNA structur...
Development of a Cell-Based Recombinant Green Fluorescent Protein Assay System for Generalized Discovery of Viral Protease Inhibitors [0.03%]
一种用于常规发现病毒蛋白酶抑制剂的基于细胞的重组绿色荧光蛋白测定系统的开发
Yan Feng,Xiaoyan Wu,Ruiting Chen et al.
Yan Feng et al.
Viral proteases are critical targets for antiviral drug development, but current screening methods for protease inhibitors often require high biosafety levels or lack cell-based relevance. Here, we developed a novel cell-based assay system ...
Conformational Heterogeneity Underlying Divergent Signaling in Class A G Protein-Coupled Receptors [0.03%]
类A G蛋白偶联受体产生差异信号的构象异质性基础
Kyriakos Georgiou,Antonios Kolocouris
Kyriakos Georgiou
Class A G protein-coupled receptors (GPCRs) are targets for ∼36% of commercial drugs. GPCRs in their apo-forms exhibit conformational heterogeneity, and more than a single active and inactive conformation exists in equilibrium. Distinct tr...
Mapping the Progression of Therapy-Induced Senescence to Therapy Tolerance: An Evolutionarily Conserved Mechanism for Optimizing Cancer Treatment with Senotherapeutics [0.03%]
将由治疗诱导衰老进展至治疗耐受的机制映射出来：一种通过使用抗衰老疗法优化癌症治疗的进化保守机制
Gargi Mukherjee,Neha Dutta,Muthumeena Ramanathan et al.
Gargi Mukherjee et al.
Therapy-induced senescence (TIS) is a reversible growth arrest induced by anticancer treatments, which may contribute to the development of long-term therapy resistance in tumor cells. Senotherapeutics, agents targeting senescent cells, are...