Cathepsin B‑Responsive Phosphatidylinositol 3‑Kinase (PI3K) Prodrug for the Treatment of Pulmonary Fibrosis [0.03%]
Xiaomei Li,Tao Yang,Shuyue Lei et al.
Xiaomei Li et al.
PI3K inhibitors are effective therapeutic agents for pulmonary fibrosis, but they are plagued by systemic toxicity and a narrow therapeutic window. To overcome this limitation, we developed a novel enzyme-responsive prodrug delivery system ...
Ferroptosis: A Key Mechanism in Alcohol-Induced Mitochondrial Dysfunction and Oxidative Stress [0.03%]
Gouthami Kuruvalli,Nagajyothi Chidanandha Patnamsetty,Padmavathi Pannuru et al.
Gouthami Kuruvalli et al.
Alcoholic liver disease (ALD) is a complex condition marked by mitochondrial dysfunction, oxidative stress, and hepatocellular death. Among the various mechanisms involved, ferroptosis, a regulated form of cell death driven by iron-dependen...
Lorena Cera Bandeira,Leonardo Pinto,Fernanda de Lima Moreira et al.
Lorena Cera Bandeira et al.
The high variability in efficacy and safety of antichagasic chemotherapy involving benznidazole (BNZ) may be due to pharmacokinetic-related factors. The study evaluated the impact of experimental acute and chronic infections by the Berenice...
Differential Effects of Acute and Chronic Fluoxetine on Psychedelic-Induced Behavior in Mice: Implications for Clinical Trials [0.03%]
Bo Jarrett Wood,M Frances Vest,Catharine Carfagno et al.
Bo Jarrett Wood et al.
Selective serotonin reuptake inhibitors (SSRIs) are widely prescribed for mood and anxiety disorders, the same conditions under which psychedelic-assisted therapies are gaining renewed interest. However, it remains unclear how SSRI treatmen...
Impact of Side Chain Structure and Aglycon Carbonyl Group on the Immunostimulatory Activities of Semisynthetic Saponin Adjuvants [0.03%]
Di Bai,Liz Wang,Rebekah Beyea et al.
Di Bai et al.
VSA-1 and VSA-2 are recently developed semisynthetic saponin immunostimulants derived from natural Momordica saponins (MS) I and II, respectively, through the incorporation of a linear dodecyl or benzyl undecanoate side chain. In this study...
Mavacamten Derivatives Significantly Ameliorate Lipopolysaccharide-Induced Acute Lung Injury, Partly by Modulating Nuclear Factor Kappa‑B Signaling [0.03%]
Anjali Veeram,Rahul Shingare,Nithya Sree Pr et al.
Anjali Veeram et al.
Acute lung injury (ALI) and Acute respiratory distress syndrome (ARDS) are critical pulmonary disorders marked by excessive inflammation and cytokine storm, often resulting in respiratory failure and high mortality, especially if untreated....
Cytochrome P450 2D6 (CYP2D6) Inhibition by Bergamottin and Diosmetin as a Strategy to Enhance the Pharmacokinetics and Antidepressant Efficacy of Amoxapine [0.03%]
Sachin Dattram Pawar,Shreyash Santosh Yadav,Sai Sharanya Pulimamidi et al.
Sachin Dattram Pawar et al.
Amoxapine (AMX) is an FDA-approved tricyclic antidepressant used to treat major depressive disorders by modulating monoaminergic neurotransmitters, including serotonin, dopamine, and noradrenaline. However, its clinical efficacy is limited ...
Kavita A Iyer,Rumiana Koynova-Tenchov,Janet M Sasso et al.
Kavita A Iyer et al.
Epigenetics, the study of heritable changes in gene expression that do not involve alterations to the DNA sequence, has emerged as a transformative field in biology and medicine, revealing how gene expression is modulated in response to int...
Effect of a Negatively Charged Amino Acid Linker on the Tumor-Targeting Properties of [177Lu]Lu-Labeled 4‑ p‑(Tolyl)butyric Acid-Conjugated Alpha-Melanocyte-Stimulating Hormone Peptides [0.03%]
Zheng Qiao,Jingli Xu,Fabio Gallazzi et al.
Zheng Qiao et al.
This study aimed to examine how negatively charged amino acid linkers influence the tumor-targeting and biodistribution properties of [177Lu]-Lu-labeled 4-p-(tolyl)-butyric acid (p-TBA)-conjugated alpha-melanocyte-stimulating hormone peptid...
96-Well Format-Based Liver-Heart-on-a-Chip Platform for Facile and Parallel Testing of Drug-Induced Cardiotoxicity after Liver Metabolism [0.03%]
Sebeen Lee,Chaewon Jin,Hongsoo Choi et al.
Sebeen Lee et al.
Current preclinical drug evaluation predominantly relies on conventional two-dimensional (2D) cell cultures grown in static environments, which lack dynamic interactions and fail to recapitulate complex microenvironments. These approaches a...