Spore-Forming Probiotic-Embedded Biomaterials for Targeted Gut Microplastic Biodegradation [0.03%]
用于靶向肠道微塑料生物降解的孢子型益生菌嵌入式生物材料
George Michael Nicolas,Tianying Yuan,Andriansjah Rukmana et al.
George Michael Nicolas et al.
Microplastic (MP) exposure compromises gut barrier integrity, microbial homeostasis, and host immunity to accelerate mucosal dysfunction and disease progression. This necessitates new strategies to address gut MP accumulation concerns. Unli...
Discovery, Structural Characterization, and Preclinical Evaluation of Monoclonal Antibodies against Xylazine Poisoning [0.03%]
塞拉西恩中毒的单克隆抗体的发现、结构表征和临床前评估
Jason Kang,Ruowen Xu,Shea Lee et al.
Jason Kang et al.
Xylazine is a nonopioid sedative that has emerged as a major adulterant in the illicit drug supply, contributing to rising fatal overdoses across the United States. Xylazine toxicity is not reversed by naloxone, and there are no current FDA...
Development of Radioligand Therapy-Responsive Syngeneic Prostate Models through Murine Prostate-Specific Membrane Antigen Point Mutation [0.03%]
通过小鼠前列腺特异性膜抗原点突变开发可响应放射配体治疗的同基因前列腺模型的发展
Mathis Richard,Beatrice Louis,Marco F Taddio et al.
Mathis Richard et al.
Robust, reproducible, and meaningful research requires suitable murine preclinical models that effectively mimic the disease and possess a functional immune system. In the context of metastatic castration-resistant prostate cancer (mCRPC) s...
Cannabinoid 2 Receptor Activation Mitigates High-Fat Diet/Streptozotocin-Induced Nonalcoholic Fatty Liver Disease in Diabetic Mice by Modulation of Oxidative Stress, Inflammation, and Fibrosis [0.03%]
大麻素受体2激活通过调节氧化应激、炎症和纤维化减轻糖尿病小鼠高脂饮食/链脲佐菌素诱导的非酒精性脂肪肝病
Hebaallah Mamdouh Hashiesh,M F Nagoor Meeran,Seenipandi Arunachalam et al.
Hebaallah Mamdouh Hashiesh et al.
Nonalcoholic fatty liver disease (NAFLD) represents one of the multifactorial complications of type 2 diabetes (T2D). The cannabinoid type 2 receptor (CB2R) plays a role in diabetes and diabetic complications; therefore, the aim of the pres...
Toward a Therapy for Autism Spectrum Disorder: The Formyl Peptide Receptor 2 Agonist MR-39 Supports Synaptic Health in the BTBR Mouse and Features a Favorable Safety Profile [0.03%]
自闭症谱系障碍的治疗新希望：小分子MR-39通过激活甲酰肽受体样2，改善自闭症模型BTBR小鼠突触健康且安全性良好
Daniele Vitone,Fabio Francavilla,Maria Grazia Ferraro et al.
Daniele Vitone et al.
Chronic unresolved inflammation is a common feature of several Central Nervous System (CNS) disorders, including autism spectrum disorder (ASD). We previously demonstrated that Formyl Peptide Receptor 2 (FPR2) activation by our agonist MR-3...
Advanced Spray-Dried Cyanidin Chloride Inhalable Dry Powders with High Aerosol Dispersion Performance and Mitochondrial Bioenergetics Modulation for Targeted Pulmonary Delivery [0.03%]
一种用于靶向肺部输送的具有高气溶胶分散性能和线粒体生物能调节作用的高级喷雾干燥花色氯化物干粉吸入剂
Hasham Shafi,Priya Muralidharan,David Encinas-Basurto et al.
Hasham Shafi et al.
Using an organic solution-based, closed-mode spray drying particle engineering approach, Cyanidin chloride, a natural flavonoid with potent antioxidant and anti-inflammatory properties, was designed into inhalable powders for targeted pulmo...
Pristimerin Suppresses Janus Kinase/Signal Transducers and Activators of Transcription Oncogenic Signaling To Drive Mitochondrial and Caspase-Dependent Apoptosis in Multiple Myeloma [0.03%]
Pristimerin通过驱动线粒体和半胱天冬酶依赖性凋亡抑制Janus激酶/信号转导子和转录激活子致癌信号传导在多发性骨髓瘤中的作用
Zahwa Mariyam,Kirti S Prabhu,Ummu Habeeba et al.
Zahwa Mariyam et al.
Multiple myeloma (MM) is a plasma cell malignancy characterized by uncontrolled clonal expansion within the bone marrow, and despite major therapeutic advances, it remains largely incurable. The identification of novel agents capable of ove...
Urease Inhibitors from Nasturtium officinale Extract for the Treatment of Urease Expressing Bacterial Infections [0.03%]
蔊菜提取物尿酶抑制剂对尿酶阳性细菌感染的治疗作用研究
Rachel Heylen,Emily Owen,Kyle Stewart et al.
Rachel Heylen et al.
Urease is a virulence factor associated with Helicobacter pylori infections, catheter-associated urinary tract infections, and incontinence associated dermatitis. Currently, few treatment options are available to treat urease-positive infec...
Regulation of Renal Transporters by Pro-Inflammatory Cytokines in Human Proximal Tubular Epithelial Cells: Identification of the Perpetrator and Mechanisms [0.03%]
促炎症细胞因子通过人近端小管上皮细胞调节肾转运蛋白：犯案者和机制的鉴定
Yik Pui Tsang,Kai Wang,Edward J Kelly et al.
Yik Pui Tsang et al.
Infection and inflammation elevate circulating pro-inflammatory cytokines that can affect renal drug clearance. Accordingly, we sought to (i) quantify cytokine-mediated modulation of renal drug-metabolizing enzymes and transporters (DMETs) ...
Recent Advances in Organofluoroprobes for Brain Imaging: Progress, Challenges, and Future Directions [0.03%]
用于脑部成像的有机氟探针研究的新进展：现状、挑战和未来方向
Vaishnavi Anil,Daisy R Sherin
Vaishnavi Anil
The precise and early diagnosis of neurodegenerative diseases remains a major challenge because of their highly complex and multifactorial pathophysiology. However, in recent years, the potential of organofluoroprobesorganic molecules des...