Inhibition of Lin-11, Isl-1, and Mec‑3 Kinase (LIMK) Activity Attenuates Astrogliosis and Vascular Remodeling in an Experimental Model of Cuprizone-Induced Demyelination in Mice [0.03%]
抑制Lin-11、Isl-1和Mec-3激酶(LIMK)活性可减轻小鼠杯rizone诱导的脱髓鞘实验模型中的星形胶质细胞增生和血管重塑作用
Abhishek Roy,Shradha Pendbhaje,Divya Goyal et al.
Abhishek Roy et al.
A variety of neurological impairments are caused by the loss of myelin, which is a hallmark of demyelinating diseases such as multiple sclerosis (MS). The cuprizone model is a well-established demyelination model in which specific brain reg...
Cyclin-Dependent Kinases 4 and 6 Inhibitors: An Emerging Therapeutic Framework from Growth Suppression to Tumor Clearance [0.03%]
细胞周期素依赖性激酶4和6抑制剂：从抑生长到抗肿瘤的新兴治疗框架
Cong Ma,Xuan Ji,Wenqin Huang et al.
Cong Ma et al.
This review explores strategies to overcome the clinical limitations of Cyclin-dependent kinases 4 and 6 (CDK4/6) inhibitors, namely, reversible cytostasis and acquired resistance. We outline an emerging therapeutic framework in which these...
Sertraline Enhances Bacterial Control without Adversely Affecting the Pharmacodynamic-Pharmacokinetic Properties of Frontline Tuberculosis Drugs [0.03%]
塞瑞替尼增强细菌控制作用且不会影响一线结核病药物的药动学和药效学性质
Kanika Bisht,Monica Yadav,Mahima Madan et al.
Kanika Bisht et al.
Host-directed therapies (HDTs) are gaining importance as innovative intervention strategies for shortening the treatment durations of tuberculosis (TB), a major public health burden. The combination of TB drugs and sertraline (SRT), an FDA-...
Repurposing FDA-Approved Drugs as Potential Inhibitors of Feline Infectious Peritonitis Virus 3CLpro: An Integrated In Silico and In Vitro Study with Synergistic Combination Analysis [0.03%]
一种体外和基于计算机的体内实验相结合研究：将美国食品药品监督管理局已批准的药物重新配制为猫传染性腹膜炎病毒3CLpro潜在抑制剂及其协同组合分析
Varanya Lueangaramkul,Natjira Mana,Nattarat Thangthamniyom et al.
Varanya Lueangaramkul et al.
Feline infectious peritonitis (FIP), caused by feline coronavirus (FCoV) remains a critical therapeutic challenge with no universally approved treatments. We employed a drug repurposing strategy targeting the viral main protease (3CLpro), e...
Overcoming Pharmacokinetic and Peripheral Safety Challenges in Psychedelic Therapies: The Promise of Advanced Drug Delivery Systems [0.03%]
应对迷幻疗法中的药代动力学和外周安全挑战：先进药物输送系统的前景
Tianshu Zhang,Cong Lin,Xiaohui Wang
Tianshu Zhang
Classic serotonergic psychedelics-such as lysergic acid diethylamide (LSD), psilocybin, and N,N-dimethyltryptamine (DMT)-hold remarkable promise for treating neuropsychiatric disorders, yet their clinical translation is severely constrained...
Head-to-Head Comparison of Monomeric, Homodimeric, and Heterodimeric Fibroblast Activation Protein-Targeting Radioligands Based on Small Molecule Inhibitor and Cyclic Peptide [0.03%]
基于小分子抑制剂和环肽的成纤维细胞活化蛋白靶向放射配体的头对头比较（单聚体、同二聚体和异二聚体）
Kosuke Saito,Hiroyuki Watanabe,Kazuma Nakashima et al.
Kosuke Saito et al.
Fibroblast activation protein (FAP) has been identified as a promising biomarker for tumor-targeting radioligands. Among these, a small molecule FAP inhibitor (FAPI), [68Ga]-Ga-FAPI-46, and a cyclic peptide-based FAP-targeting radioligand, ...
Cell-Penetrating Peptide-Mediated Modulation of Endoplasmic Reticulum Stress: A Bioengineered and Translational Approach [0.03%]
细胞穿透肽介导的内质网应激调节：生物工程与转化医学方法
Tripti Paliwal,Radhika Joshi,Sarvesh Paliwal et al.
Tripti Paliwal et al.
Endoplasmic reticulum (ER) stress is central to the onset and progression of metabolic and inflammatory disorders, such as insulin resistance, hepatic steatosis, and cardiovascular dysfunction. The unfolded protein response, triggered by ER...
Age-Driven Physiologically Based Pharmacokinetic Modeling of Empagliflozin: Toward Precision Dosing in Youth [0.03%]
恩格列净的基于生理的药代动力学模型在青少年中的精准给药研究
Gabriela Pereira Milhm,Fernanda de Lima Moreira,Bárbara de Azevedo Abrahim-Vieira
Gabriela Pereira Milhm
Type 2 diabetes mellitus (T2DM) is a multifactorial disease that affects both adults and children. Treating T2DM in children poses a challenge because of the difficulties in conducting clinical trials in this special population. Empaglifloz...
A New Nitroimidazole-Based Drug Attenuates Skeletal Myositis and Overcomes Benznidazole Resistance in Experimental Chagas Disease [0.03%]
一种新型硝基咪唑类药物可改善骨骼肌炎和克服实验室查加斯病的苯硝唑耐药性
Graziela Domingues De Almeida Lima,Elda Gonçalves-Santos,Monique Dias Benedetti et al.
Graziela Domingues De Almeida Lima et al.
Skeletal myositis is a disabling complication of Chagas disease for which the first-choice antiparasitic chemotherapy has limited efficacy. Therefore, we synthesized and investigated the potential of the novel nitroimidazole-based drug 1-(2...
Antimicrobial Systems Based on Essential Oils Advanced by Zinc Oxide Nanoparticles [0.03%]
基于氧化锌纳米粒子的精油抗菌系统的发展
Greta Kaspute,Urte Prentice,Roman Viter et al.
Greta Kaspute et al.
Zinc oxide nanoparticles (ZnO NPs) have emerged as a promising material to enhance the performance of essential oils (EOs) in various applications due to their unique properties, including chemical stability, biocompatibility, and antimicro...