The Neuroimmune Connectome: Understanding how the Peripheral Nervous System shapes Immunity [0.03%]
神经免疫连接组学：理解外周神经系统如何塑造免疫力
Shanel M Tsuda,Anna-Maria Globig
Shanel M Tsuda
Nerves are active regulators of immunity. Here, we review the current understanding of neuroimmune communication, focusing on how peripheral neurons instruct immune cell differentiation and function. We discuss mechanisms by which neurotran...
Brandon J DeKosky
Brandon J DeKosky
Antibodies and T cell receptors are the molecular basis of immune memory, and have become the foundation for generations of clinically successful biologics. Decades of research have established diverse systems to observe, identify, discover...
ASPIRE to new horizons [0.03%]
展望新视野
Bonnie N Dittel
Bonnie N Dittel
Temporal variability in healthy donor IFN-γ ELISpot responses reveals a stable IL-7-responsive functional metric for immune phenotyping [0.03%]
健康供体IFN-γ ELISpot反应的时空变异性揭示了一个稳定的IL-7反应功能指标用于免疫表型分析
Annemarie Nguyen,Ruth-Ann Brown,Anthony S Bonavia
Annemarie Nguyen
Functional T-cell assays such as the IFN-γ ELISpot are increasingly used for immune phenotyping in infection, cancer, and critical illness. Many studies, including recent work linking low IFN-γ ELISpot responses to adverse outcomes in sep...
ZBP1 mediated restriction of Toxoplasma gondii in both the early acute and chronic brain stages of infection [0.03%]
黏附型乳腺癌脑转移早期和慢性期感染中ZBP1介导的弓形虫限制作用
Lydia Anne Sibley,Isaac William Babcock,Naa Dedee Amadi et al.
Lydia Anne Sibley et al.
ZBP1 is an innate sensor of nucleic acids in the Z-conformation and regulates immune responses via cell death pathways and nuclear factor κB signaling. Previous work has demonstrated an essential role for ZBP1 in viral restriction; however...
Presentation of the protective epitope in a Chlamydia muridarum MOMP vaccine is dependent on γ-interferon-inducible lysosomal thiol reductase (GILT) [0.03%]
γ-干扰素诱导的溶酶体硫醇还原酶(GILT)决定沙眼衣原体鼠亚种(MoMP疫苗株)保护性表位的表达
Sukumar Pal,Raymond M Johnson,Delia F Tifrea et al.
Sukumar Pal et al.
The Chlamydia outer membrane complex has approximately 20 cysteine-rich proteins, including the major outer membrane protein (MOMP) with 8 cysteines. The enzyme γ-interferon-inducible lysosomal thiol reductase (GILT) is expressed constitut...
Bone marrow and splenic immune composition is unperturbed by short-term exposure to bedding from pet store mice [0.03%]
宠物店小鼠床品短期暴露不会扰动摇骨髓和脾脏免疫组成
Sarah E Little-Letsinger,Peer W F Karmaus,Michael B Fessler et al.
Sarah E Little-Letsinger et al.
Mice with natural microbial exposures (NMEs) have been proposed to be superior to specific pathogen-free (SPF) laboratory mice for modeling adult human immune and inflammatory profiles. Research using NME mice has focused on the effects of ...
TGF-β-induced Tregs release extracellular vesicles that modulate CD4+ T-cell proliferation and phenotype in a Nrp1-dependent manner [0.03%]
TGF-β诱导的Tregs释放外泌体以Nrp1依赖性方式调节CD4+T细胞增殖和表型
María José Moya-Guzmán,Eduardo González-Mienert,Camila Pinto et al.
María José Moya-Guzmán et al.
Neuropilin-1 (Nrp1) is one of the receptors for TGF-β and is associated with the suppressive function of T regulatory cells (Tregs). Based on previous findings on natural Tregs, this work investigated the role of Nrp1 on induced Tregs (iTr...
SHIP-1 adapter functions mediate recruitment of FCRL1 to the BCR and inhibition of ERK [0.03%]
SHIP-1适应因子介导BCR募集FCRL1和抑制ERK
Malory M Wolfe,Rut Tallon Arranz,Elizabeth L Zenni et al.
Malory M Wolfe et al.
FCRL1 is a plasma membrane coreceptor on B cells that has been shown to potentiate B cell receptor (BCR)-driven calcium flux and negatively regulate ERK phosphorylation in a GRB2 and tyrosine-dependent manner. Of the proteins that associate...
Feng Gao,Yongzheng W Chen,Steven D Shapiro et al.
Feng Gao et al.
PDLIM2, a PDZ-LIM domain-containing protein expressed highest in the lung and immune cells, serves as a unique tumor suppressor and immune modulator, mainly by turning off the activation of the master transcription factors NF-κB and STAT3....