The language of the immune system: Part 1: Cytokine conversations and conversationalists [0.03%]
免疫系统的语言 第1部分：细胞因子对话及对话发起者
Ken Steven Rosenthal
Ken Steven Rosenthal
The immune system is always acting to protect the body from the microbial world, especially at the openings of the body but also helps to maintain homeostasis. Normal functions include self-regulation and regeneration, facilitating the main...
Cell-intrinsic IL-7Rα deficiency in Foxp3+ Tregs increases type 1 diabetes incidence in NOD mice [0.03%]
Foxp3阳性Tregs中固有的IL-7Rα缺乏增加了NOD小鼠的Ⅰ型糖尿病发病率
Albert R Jones Iv,Peyton S Smith,Hans Dooms
Albert R Jones Iv
Regulatory CD4+ T cells (Tregs), as defined by expression of the transcription factor Foxp3, strongly depend on the cytokine interleukin 2 (IL-2) for their survival and function and are often identified by the combination of high IL-2Rα (C...
CFTR modulators exert subset-specific phenotype remodeling on circulating neutrophils in cystic fibrosis [0.03%]
囊性纤维化患者循环中中性粒细胞的亚群特异性表型重塑对CFTR调控剂的反应
François Chable de la Héronnière,Théo Dhôte,Rodrigo de Oliveira Formiga et al.
François Chable de la Héronnière et al.
A key aspect of cystic fibrosis pathophysiology is the significant role played by neutrophils, central to the inflammatory response in cystic fibrosis airways. Neutrophil-dominated inflammation greatly influences clinical outcomes, includin...
Absence of insulin receptor substrate 2 (IRS2) in myeloid cells results in enhanced hypoxia-induced remodeling of the pulmonary vasculature and heart with modest effects on allergic lung inflammation [0.03%]
髓样细胞中缺乏胰岛素受体底物2（IRS2）可增强缺氧引起的肺血管和心脏重塑，并对过敏性肺部炎症产生适度影响
Luz M Villanueva,Homare Ito,Xiulan Qi et al.
Luz M Villanueva et al.
We previously reported that global insulin receptor substrate-2 (IRS2)-deficient mice demonstrated enhanced pulmonary vascular remodeling in response to allergen exposure or to hypoxia. To evaluate the specific contribution of IRS2 in myelo...
Semaphorin 3E regulates the response of regulatory T cells to lipopolysaccharide-induced systemic inflammation [0.03%]
Semaphorin 3E调节调节性T细胞对脂多糖诱导的全身炎症的反应
Sina Taefehshokr,Ifeoma Okwor,Lianyu Shan et al.
Sina Taefehshokr et al.
Sepsis is a life-threatening systemic inflammation marked by an initial hyperinflammatory phase. Tregs are pivotal in tempering this early immune response. Semaphorins, originally neuronal guidance cues, have emerged as immune modulators. N...
Dysregulated myelopoiesis and enhanced glutaminase-dependent neutrophil survival in preclinical obesity [0.03%]
肥胖小鼠中调节异常的髓样细胞生成及谷氨酰胺酶依赖的中性粒细胞存活增强现象
Madison Babcock,Aric Lechner,Julia Drolet et al.
Madison Babcock et al.
Obesity is increasingly recognized as a state of chronic low-grade inflammation associated with altered immune cell function, yet the mechanisms driving these changes remain incompletely understood. This study investigated myeloid cell subp...
Non-animal models in undergraduate education: opportunities, applications, and future directions [0.03%]
非动物模型在本科教育中的应用：机遇、应用和未来方向
Sarah Teakel,Joanne Connolly,Thiru Vanniasinkam et al.
Sarah Teakel et al.
The use of animals in education and research has received increased scrutiny due to ethical and pedagogical considerations. Researchers have used non-animal models in immunology, medical, and veterinary disciplines for decades. Conversely, ...
Identification of genetic variants in B cell expressed genes associated with systemic lupus erythematosus in African American females [0.03%]
鉴定系统性红斑狼疮非洲美国女性B细胞表达基因中的遗传变异体
Rachel Kidwell,Mansi Gupta,Jake Fontaine et al.
Rachel Kidwell et al.
Systemic lupus erythematosus (SLE) is a complex autoimmune disease characterized by dysregulated B cell responses and pathogenic autoantibody production. Given the central role that B cells play in SLE pathogenesis, we aimed to characterize...
Intermittent fasting alters the antigen-specific CD5+ B-1 cell natural antibody repertoire in male and female mice [0.03%]
间歇性禁食可改变小鼠性别特异性CD5+B-1细胞天然抗体库
Sarah E Webster,Jordan Terry,Naomi L Tsuji et al.
Sarah E Webster et al.
Natural antibodies (NAbs), primarily produced by CD5+ B-1 cells, provide critical early protection against infections such as Streptococcus pneumoniae. The structure of these natural antibodies, germline-like with minimal N-additions, is es...
Johnathon B Schafer,Kenneth C Malcolm,Jessica Dell-Martin et al.
Johnathon B Schafer et al.
Patients with myelodysplastic syndrome (MDS) are immunocompromised and are therefore susceptible to fatal infection. While neutropenia and neutrophil dysfunction account for much of this immunodeficiency, other immune cells likely also cont...