Delineation of the antibody light chain biases and kinetics following primary and secondary influenza virus infections of ferrets [0.03%]
划定经过初次和再次流感病毒感染的雪貂中的抗体轻链偏差和动力学
Robert A Richardson,Thomas Rowe,Greg A Kirchenbaum et al.
Robert A Richardson et al.
The ferret is considered the "gold standard" animal model for influenza virus research. However, the mechanisms of the ferret humoral immune responses remain understudied. Here, the kinetic profile of the influenza A or B virus hemagglutini...
Peptide-adaptive NK cell memory in the absence of functional TCR genes [0.03%]
缺乏功能性TCR基因的肽适应性NK细胞记忆
Safyha Bryan,Gayani S Gamage,Sayanti Dey et al.
Safyha Bryan et al.
Natural killer (NK) cells are a key component of the innate immune system and are specialized in the recognition and elimination of virally infected, tumor, and otherwise abnormal cells. However, multiple laboratories have shown that NK cel...
The orphan nuclear receptor NR4A3 is dispensable for resident memory CD8+ T-cell generation [0.03%]
孤儿核受体NR4A3对驻留记忆CD8⁺T细胞的发生是可有可无的
Livia Odagiu,Salix Boulet,Dave Maurice De Sousa et al.
Livia Odagiu et al.
Different memory CD8+ T-cell subsets are generated following acute responses: central, effector and resident (Trm). CD8+ Trm cells established residency at the sites of infection and provide an efficient and rapid frontline defense against ...
Potential CD27-CD70 interaction within adoptive T cells does not affect tumor antigen-specific T-cell immunotherapy [0.03%]
供体T细胞中CD27-CD70相互作用对肿瘤特异性过继性免疫治疗的影响较小
Eswara Rao Puppala,Mohammad A Alzubi,Habeebat Aderonke Mustapha et al.
Eswara Rao Puppala et al.
The CD27-CD70 pathway regulates T-cell activity either positively or negatively depending on the context of immune response. Typically, CD27 is known as a co-stimulatory receptor expressed on T cells while CD70 is the ligand expressed on an...
Michael C McGee,Wei Luo,Weishan Huang
Michael C McGee
Viral infections induce heterogeneous memory T and B cell populations that may rapidly recall and provide protection against re-infection. The immunomodulatory cytokine interleukin-10 (IL-10) is well described for its role in restricting im...
Expression of ultralong complementarity determining region 3 and development of IgM and IgG B cell receptor repertoires in Holstein heifer calves [0.03%]
超长补体决定区3的表达与黑白花牛犊IgM和IgG B细胞受体 repertoire的发展
Tess E Altvater-Hughes,Harold P Hodgins,Douglas C Hodgins et al.
Tess E Altvater-Hughes et al.
There are currently knowledge gaps regarding the development of the bovine B cell repertoire especially for cells expressing B cell receptors with heavy chain ultralong complementarity determining region 3 (CDR3). The objective of this stud...
Making multiple comparisons easy: a decision tree and visual statistics guide for data with more than two groups [0.03%]
多种两两比较方法的选择与应用：多组数据的决策树及可视化统计指南
Cody J Gurski,Bonnie N Dittel
Cody J Gurski
Many scientists learn during training to use analysis of variance (ANOVA) when comparing more than 2 groups, yet the principles and follow-up steps are often not well explained. This overview provides a practical guide for selecting appropr...
Interleukin-7R and chemokine receptor type 7 differentially regulate metabolism in CD4+ and CD8+ T cells [0.03%]
CD4+和CD8+T细胞中IL-7R和CCR7对T细胞代谢的调节作用不同
Kimberly A Morrissey,Miriam Valenzuela-Cardenas,Rebekah Gridley et al.
Kimberly A Morrissey et al.
Naïve T cells are highly metabolically active, maintaining homeostatic function as well as continuously moving and surveying lymph nodes for dendritic cells (DCs) presenting cognate antigen. T-cell metabolism is thought to change throughou...
Grace Turyasingura,Kagan A Mellencamp,Ruth Namazzi et al.
Grace Turyasingura et al.
Memory-like natural killer (NK) cells with enhanced antibody-dependent cellular cytotoxicity (ADCC) have correlated with protection from uncomplicated malaria in prior studies. However, the role of NK cells in severe malaria (SM) has not be...
Harnessing the microbiome to regulate myeloid TREM2 expression and innate immune responses [0.03%]
利用微生物组调节髓系TREM2表达和固有免疫反应
Saki Mihori,Frank C Nichols,Evan R Jellison et al.
Saki Mihori et al.
The composition of the gastrointestinal microbiome is correlated with numerous immune-mediated systemic diseases, but underlying mechanisms remain unclear. In murine studies, we recently identified microbiome Bacteroidota-derived bacterial ...