BRCA1 deficiency leads to aberrant epithelial differentiation in the thymus [0.03%]
BRCA1缺陷导致胸腺上皮细胞分化异常
Chikako Odaka,Marieke van de Ven,Panagiota Sotiropoulou et al.
Chikako Odaka et al.
BRCA1 (breast cancer 1, early onset) is originally identified as a tumor suppressor in hereditary breast and ovarian cancer. Recent studies have suggested that BRCA1 contributes to the cell fate decisions in mammary epithelium. Although BRC...
Rapid decline of SARS-CoV-2-specific salivary IgA antibody levels in people with hybrid immunity-data from the STOPCoV study [0.03%]
来自STOPCoV研究的具有混合免疫的人群中SARS-CoV-2特异性唾液IgA抗体水平快速下降的数据
Sharon L Walmsley,Majid Nabipoor,Gary Chao et al.
Sharon L Walmsley et al.
Hybrid immune individuals who experience an infection after a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mRNA vaccine series show evidence of salivary anti-spike and anti-receptor binding domain (RBD) IgA antibodies with b...
Preceding influenza infection impacts neutrophil response to Aspergillus fumigatus and Staphylococcus aureus [0.03%]
流感病毒感染影响中性粒细胞对烟曲霉和金黄色葡萄球菌的反应
Nima Naghshtabrizi,Kara L Nickolich,Ravineel B Singh et al.
Nima Naghshtabrizi et al.
Influenza infection predisposes individuals to secondary pneumonia caused by a range of pathogens, including both bacterial and fungal organisms. Neutrophils are critical effector cells during infection. In this study, we analyzed the trans...
Individuals with latent tuberculosis infection display pulmonary airway enrichment and recall recruitment of CD4+ TRM with protective functional phenotypes [0.03%]
潜伏性结核感染者表现出具有保护功能表型的CD4+TRM肺部气道丰富和再活化招募现象
Jessica R Jarvela,Julie G Burel,Michelle Moyer et al.
Jessica R Jarvela et al.
Tuberculosis (TB) remains a worldwide public health threat, in part because of the limited efficacy of current BCG vaccination. Respiratory infection with Mycobacterium tuberculosis (Mtb) is most often followed by the development of protect...
CD4 and CD8 T-cell response is dominated by IL-10-secreting cells in children with uncomplicated Plasmodium falciparum malaria [0.03%]
单纯感染恶性疟原虫的儿童中CD4和CD8T细胞反应以分泌IL-10的细胞为主
Bonface O Ariera,Bernard Guyah,Ian Onditi et al.
Bonface O Ariera et al.
Plasmodium falciparum malaria and Epstein-Barr virus (EBV) coinfections have been associated with an increased risk of developing the EBV-associated cancer endemic Burkitt lymphoma (eBL). In children living in malaria-endemic areas, repeate...
IL-13 protects epithelial cells from SARS-CoV-2 infection by inhibiting ACE2-mediated virus binding and cell entry [0.03%]
白细胞介素13通过抑制ACE2介导的病毒结合和细胞进入来保护上皮细胞免受新冠病毒感染
Vadim Pivniouk,Oksana Pivniouk,Jennifer L Uhrlaub et al.
Vadim Pivniouk et al.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) preferentially infects airway epithelial cells. This infection is mediated by the binding of SARS-CoV-2 spike (S) protein to ACE2 expressed on target cells. Patients with allergic...
Polymorphisms in FCN genes and their influence on systemic lupus erythematosus susceptibility: a report from Western India [0.03%]
补体因子H和相关基因多态性与印度西部系统性红斑狼疮易感性的关系研究
Kirti Rai,Ridi Khatri,Amrutha Jose et al.
Kirti Rai et al.
Ficolins, encoded by FCN genes, are key pattern recognition molecules of the lectin complement pathway involved in immune complex clearance, a process often impaired in systemic lupus erythematosus (SLE). Genetic polymorphisms in FCN genes ...
Disrupting the TRAF1/cIAP2 interaction attenuates inflammasome activation and protects against monosodium urate crystal-induced arthritis [0.03%]
干扰TRAF1/cIAP2相互作用可抑制炎性小体活化并预防尿酸晶体诱导的关节炎症
Sahib Singh Madahar,Ali Mirzaesmaeili,Jonathan Raspanti et al.
Sahib Singh Madahar et al.
Tumor necrosis factor receptor (TNFR)-associated factor 1 (TRAF1) regulates NF-κB signaling and is implicated in chronic autoimmune diseases characterized by persistent inflammation. In addition to its role in restraining linear ubiquitin ...
A widely used EYFP-based Cre reporter mouse line fails to detect a significant fraction of Cre+ T cells [0.03%]
一种常用的EYFP基CRE报告小鼠系未能检测出大量CRE+T细胞
Geoffrey S Kansas
Geoffrey S Kansas
The ability to manipulate the mouse genome has contributed heavily to countless discoveries in biology for several decades. The Cre/loxP system enables conditional and inducible deletion of virtually any sequences in the mouse. Because Cre ...
Bonnie N Dittel
Bonnie N Dittel