Laura I Yousif,Aukje G Sijtema,Ymke Appels et al.
Laura I Yousif et al.
Immune checkpoint inhibitor (ICI)-mediated myocarditis is a notorious complication of cancer treatment; however, the role of immune checkpoints in the heart during inflammation remains unknown. We investigated myocardial expression of progr...
JP2 and JCN Crosstalk Abrogate MURF1-Mediated JCN Ubiquitination and Degradation in Cardiomyocytes [0.03%]
JPN和JCN的相互作用通过破坏肌肉RIN介导的JCN泛素化及其降解来抑制心肌细胞中JCN的作用
Xiaoyun Ji,Yifan Huang,Jinxi Wang et al.
Xiaoyun Ji et al.
Junctophilin-2 (JP2) and junctin (JCN) are key proteins in maintaining calcium homeostasis in cardiomyocytes. Both are reduced in diseased hearts while overexpression of JP2 mitigates heart failure. This study demonstrates that JP2 and JCN ...
Endothelial Senescence Drives Deleterious Endothelial-Adipocyte Cross-Talk in Patients With Heart Failure and Type 2 Diabetes [0.03%]
糖尿病心脏衰竭患者中血管内皮衰老驱动的不良内皮脂肪细胞相互作用
Oliver I Brown,Katherine I Bridge,Alexander-Francisco Bruns et al.
Oliver I Brown et al.
Subcutaneous adipose tissue microvascular endothelial cells (MVECs) from patients with type 2 diabetes mellitus and heart failure exhibit a senescent phenotype characterized by elevated senescence-associated secretory phenotype markers, red...
Pulmonary Endothelium: A Driver and Therapeutic Target in Pulmonary Hypertension [0.03%]
肺内皮细胞在肺动脉高压中的驱动作用及治疗价值
Anita Kovacs-Kasa,Brian H Annex
Anita Kovacs-Kasa
GPT2-mediated Glutamate to α-Ketoglutaric Acid Conversion in Cardiac Fibroblast Promotes Fibrosis [0.03%]
心房纤维化中GPT2介导的谷氨酸向α-酮戊二酸转化的作用机制研究
Yongjian Chen,Fei Liao,Jingyi Wang et al.
Yongjian Chen et al.
Cardiac fibroblasts play a key role in heart fibrosis, but how their metabolism changes during this process is unclear. This study shows that mesenchymal stem cell-derived extracellular vesicles reduce fibrosis in mice after heart pressure ...
eNOS Uncoupling-ER Stress-Mitochondrial Dysfunction Axis in the Development of Pulmonary Hypertension [0.03%]
肺动脉高压发病中eNOS脱偶联-内质网应激-线粒体功能障碍轴的作用
Priya Murugesan,Yunxia Zhang,Meng Zhang et al.
Priya Murugesan et al.
Pulmonary hypertension (PH) was induced by 2,4-diamino 6-hydroxypyrimidine or hypoxia exposure. Remarkably, folic acid (attenuating endothelial nitric oxide synthase [eNOS] uncoupling) or phenylbutyric acid (abrogating endoplasmic reticulum...
Stéfanie Parisien-La Salle,Cheng-Hsuan Tsai,Andrew J Newman et al.
Stéfanie Parisien-La Salle et al.
Understanding hormonal mechanisms of obesity-related hypertension may inform targeted therapy. Participants with obesity and hypertension underwent deep-phenotyping procedures to detect the primary aldosteronism phenotype, low-renin phenoty...
Stress-Induced Down-Regulation of CPEB4 Disrupts Sodium Channel Regulation and Myocardial Excitability [0.03%]
应激诱导的CPEB4下调扰乱钠通道调节和心肌兴奋性
Gyeoung-Jin Kang,Eunji Kim,An Xie et al.
Gyeoung-Jin Kang et al.
Unstable ion channel mRNAs contribute to electrical remodeling and arrhythmic risk in heart failure. CPEB4 promotes cytoplasmic polyadenylation and stabilizes target mRNAs, thereby supporting translation. CPEB4 expression was reduced in hum...
Methylated PIH1D1 as a Circulating Biomarker for Anthracycline-Related Cardiac Remodeling: Promise and Pragmatics [0.03%]
PIH1D1甲基化作为蒽环类药物相关心脏重构循环生物标志物的希望与实践
Chris J Pemberton
Chris J Pemberton
Methylated PIH1D1 as a Heart-Specific Biomarker for Anthracycline-Induced Cardiac Remodeling in Breast Cancer Patients [0.03%]
PIH1D1甲基化作为乳腺癌患者蒽环类药物诱导的心脏重塑的特异性标志物
Po-Yen Hsu,Wan-Hong Huang,Yi-Yun Lee et al.
Po-Yen Hsu et al.
Anthracyclines, key chemotherapy agents, pose cardiotoxicity risks. In a 3-year study of 89 breast cancer patients treated with doxorubicin or epirubicin, more than 50% showed reduced left ventricular ejection fraction and progressive ventr...