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eNOS Uncoupling-ER Stress-Mitochondrial Dysfunction Axis in the Development of Pulmonary Hypertension

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Pulmonary hypertension (PH) was induced by 2,4-diamino 6-hydroxypyrimidine or hypoxia exposure. Remarkably, folic acid (attenuating endothelial nitric oxide synthase [eNOS] uncoupling) or phenylbutyric acid (abrogating endoplasmic reticulum stress) markedly al... ...