Biogenesis and roles of tRNA queuosine modification and its glycosylated derivatives in human health and diseases [0.03%]
tRNA含鸟昔衍生物修饰的生物发生及其在人类健康和疾病中的作用
Tsutomu Suzuki,Atsuya Ogizawa,Kensuke Ishiguro et al.
Tsutomu Suzuki et al.
Various types of post-transcriptional modifications contribute to physiological functions by regulating the abundance and function of RNAs. In particular, tRNAs have the widest variety and largest number of modifications, with crucial roles...
Insights into biofilm architecture and maturation enable improved clinical strategies for exopolysaccharide-targeting therapeutics [0.03%]
生物被膜结构和成熟的见解能够改善临床策略，用于外多糖靶向治疗
J Sebastian Temme,Zibin Tan,Mi Li et al.
J Sebastian Temme et al.
Polysaccharide intercellular adhesin (PIA), an exopolysaccharide composed of poly-N-acetyl glucosamine (PNAG), is an essential component in many pathogenic biofilms. Partial deacetylation of PNAG is required for biofilm formation, but limit...
Platelets accelerate lipid peroxidation and induce pathogenic neutrophil extracellular trap release [0.03%]
血小板加速脂质过氧化并诱导致病性中性粒细胞胞外陷阱释放
Madoka Ono,Masayasu Toyomoto,Momono Yamauchi et al.
Madoka Ono et al.
Neutrophil extracellular traps (NETs), an important host defense mechanism, are assembled after the release of decondensed chromatin and other nuclear components by a process termed NETosis. However, excessive NET release destroys surroundi...
β-hydroxybutyrate is a metabolic regulator of proteostasis in the aged and Alzheimer disease brain [0.03%]
β-羟丁酸是调节衰老和阿尔茨海默病脑蛋白稳态的代谢物
Sidharth S Madhavan,Stephanie Roa Diaz,Sawyer Peralta et al.
Sidharth S Madhavan et al.
Loss of proteostasis is a hallmark of aging and Alzheimer disease (AD). We identify β-hydroxybutyrate (βHB), a ketone body, as a regulator of protein solubility. βHB primarily provides ATP substrate during periods of reduced glucose avai...
An engineered cereblon optimized for high throughput screening and molecular glue discovery [0.03%]
一种用于高通量筛选和分子胶发现的工程化 cereblon
Henry J Bailey,Jonathan Eisert,Rubina Kazi et al.
Henry J Bailey et al.
The majority of clinical degraders utilize an immunomodulatory imide drug (IMiD)-based derivative that directs their target to the E3 ligase receptor cereblon (CRBN); however, identification of IMiD molecular glue substrates has remained un...
Therapeutic induction of ferroptosis in tumors using PD-L1 targeting antibody nanogel conjugates [0.03%]
利用靶向PD-L1抗体纳米凝胶诱导肿瘤细胞铁死亡的治疗研究
Mengdie Wang,Theeraphop Prachyathipsakul,Christi A Wisniewski et al.
Mengdie Wang et al.
Although programmed cell death ligand 1 (PD-L1) is best known for its role in immune suppression, tumor-intrinsic functions are emerging. Here, we report that tumor cells that express PD-L1 are sensitive to ferroptosis inducers such as imid...
Kevin A Scott,Hiroyuki Kojima,Nathalie Ropek et al.
Kevin A Scott et al.
Despite significant interest in therapeutic targeting of splicing, few chemical probes are available for the proteins involved in splicing. Here, we show that elaborated stereoisomeric acrylamide EV96 and its analogues lead to a selective T...
Arturo Carabias,Guillermo Montoya
Arturo Carabias
Nicotinamide adenine dinucleotide (NAD) is an essential metabolite, and its depletion serves as a common bacterial immune strategy against bacteriophages (phages). In a recent issue of Nature, Osterman et al.1 reveal two phage-encoded NAD r...
Decoding retrons: Breakthroughs in RT-DNA production and genome editing [0.03%]
解码重索引：RT-DNA生成和基因组编辑新进展
Wenqian Liu,Yingjia Pan,Yu Zhang et al.
Wenqian Liu et al.
Retrons are notable for their anti-phage defense functions and genome engineering applications. However, only a few retrons have been well characterized. In the August issue of Nature Biotechnology, Khan et al.1 present hundreds of experime...
A yeast-based oral therapeutic delivers immune checkpoint inhibitors to reduce intestinal tumor burden [0.03%]
一种酵母口服治疗剂可将免疫检查点抑制剂递送至肠道以减少肿瘤负荷
Olivia N Rebeck,Miranda J Wallace,Jerome Prusa et al.
Olivia N Rebeck et al.
Engineered probiotics are an emerging platform for in situ delivery of therapeutics to the gut. Herein, we developed an orally administered, yeast-based therapeutic delivery system to deliver next-generation immune checkpoint inhibitor (ICI...