Qingxuan Chen,Ancheng Shen,Xinyi Shi et al.
Qingxuan Chen et al.
Overactive stimulator of interferon gene (STING) signaling drives inflammatory and autoimmune diseases, making STING inhibition a promising therapeutic strategy. However, the complex binding mechanisms and limited structural diversity hinde...
Redox regulation of neuroinflammatory pathways contributes to damage in Alzheimer's disease brain [0.03%]
Lauren N Carnevale,Piu Banerjee,Xu Zhang et al.
Lauren N Carnevale et al.
Aberrant activation of innate immune signaling is known to contribute to neuroinflammation in age-related neurological disorders, but the mechanisms underlying this activation remain unclear. Here, we discovered that protein S-nitrosylation...
NEK7 Cys298 is important for NLRP3 inflammasome and targetable by dimethyl fumarate [0.03%]
NEK7的半胱氨酸298对于NLRP3炎性小体是重要的且能被富马酸二甲酯靶向作用
Yandong Zhang,Helena Lindner,Brian So et al.
Yandong Zhang et al.
Dimethyl fumarate (DMF), a cysteine targeting agent, is clinically used to treat multiple sclerosis and psoriasis. However, its precise molecular mechanism remains incompletely understood. Here, we investigated the effects of DMF on NLRP3 i...
CryoSeek identification of glycofibrils with diverse compositions and structural assemblies [0.03%]
用于识别不同组成和结构组装的糖原纤维的CryoSeek技术
Zhangqiang Li,Tongtong Wang,Yitong Sun et al.
Zhangqiang Li et al.
CryoSeek is a research strategy that employs cryo-electron microscopy (cryo-EM) to discover bio-entities from accessible sources, supplemented with AI-facilitated data processing and bioinformatic analyses. Here we report CryoSeek-based cha...
Membrane lipids regulate the STING pathway and type I interferon responses [0.03%]
膜脂质调节STING通路和I型干扰素反应
Yasmine Messaoud-Nacer,Soumyabrata Guha,Nadine Laguette
Yasmine Messaoud-Nacer
The membrane lipid environment orchestrates stimulator of interferon genes (STING) signalosome assembly and downstream inflammatory responses. In two articles recently published in Nature, Li et al.1 and Tan et al.2 show that phosphoinositi...
Sorting out extracellular proteins: SORTACs harness sortilin for targeted protein degradation [0.03%]
甄别胞外蛋白：SORTAC利用sortilin进行目标蛋白降解
Chen Zhou,Xiaoyu Zhang
Chen Zhou
In this issue of Cell Chemical Biology, Gustafsen et al.1 develop sortilin-based lysosome targeting chimeras (SORTACs), which exploit sortilin-mediated endocytosis to degrade extracellular proteins. This strategy converts antibodies or smal...
Hyunwoo Kwon,Alan E Bers,David A Barbie
Hyunwoo Kwon
Clear cell renal cell carcinoma (ccRCC) with von Hippel-Lindau (VHL) loss exhibits TBK1 dependency, and targeted therapeutic strategies outside of HIF-2α inhibition have remained limited. In this issue of Cell Chemical Biology, Liao et al....
Structural insights into inhibition mechanism of the helicase-primase complex from human herpesvirus 1 [0.03%]
人型巨细胞病毒解旋酶-引物酶复合体的抑制机制及结构研究
Ko Sato,Hisashi Ishida,Toma Miyagishi et al.
Ko Sato et al.
Human herpesviruses (HHVs) are widespread pathogens causing severe diseases, especially in immunocompromised individuals, and are linked to neurodegenerative and autoimmune disorders. Current antiviral therapies primarily target the α-subf...
Genetically encoded manipulation of ATP/ADP ratio in human cells uncovers proteomic and physiological signatures of energy stress [0.03%]
基因编码的人类细胞ATP/ADP比率的操控揭露了能量压力下的蛋白质和生理特征
Alex E Ekvik,Megan M Kober,Denis V Titov
Alex E Ekvik
The ability of cells to power energy-demanding processes depends on maintaining the ATP hydrolysis reaction a billion-fold away from equilibrium. Cells respond to alterations in the energy state by sensing changes in the ratio of ATP, ADP, ...
Selective degradation of TBK1 uncovers mechanistic insights into blocking ccRCC progression [0.03%]
选择性降解TBK1揭示了阻断ccRCC进展的机制见解
Chengheng Liao,Siying Lyu,Rebecca L Johnson et al.
Chengheng Liao et al.
Clear cell renal cell carcinoma (ccRCC), the most common kidney cancer subtype, often features the inactivation of the von Hippel-Lindau (VHL) tumor suppressor, creating therapeutic vulnerabilities. Although HIF2α inhibitors have shown cli...