Chemical tools for inhibition and activity-based profiling of glucocerebrosidase in vitro and in vivo [0.03%]
用于体内外糖基 ceramide 水解酶抑制和基于活性的分析的化学工具
Shusheng Wang,Omid Tavassoly,Morshed A Chowdhury et al.
Shusheng Wang et al.
Deficiencies in glucocerebrosidase (GCase) are associated with Parkinson's disease (PD). The mechanistic basis of this association is being intensively investigated, and new treatments are being developed aiming to boost brain GCase activit...
Chemical tools for inhibition and activity-based profiling of glucocerebrosidase in vitro and in vivo [0.03%]
用于体内外葡萄糖脑苷脂酶抑制和基于活性的谱分析的化学工具
Shusheng Wang,Omid Tavassoly,Morshed A Chowdhury et al.
Shusheng Wang et al.
Deficiencies in glucocerebrosidase (GCase) are associated with Parkinson's disease (PD). The mechanistic basis of this association is being intensively investigated, and new treatments are being developed aiming to boost brain GCase activit...
An ER stress-responsive RNA rheostat for programmable gene and mRNA therapies [0.03%]
一个可应对内质网压力的RNA定量器，用于可编程基因和mRNA疗法
Roza Ogurlu,Eliya B Sanchez,Joshua A Hull et al.
Roza Ogurlu et al.
Therapeutic protein overexpression can overwhelm endoplasmic reticulum (ER) folding capacity, trigger unfolded protein response (UPR) signaling, and compromise the safety of gene and mRNA therapies. Here, we engineer stress-responsive RNA r...
Metabolic danger signals: TCA cycle metabolites regulate immunity and disease [0.03%]
三羧酸循环代谢物调节免疫和功能及代谢危险信号的研究
Tristram A J Ryan,Ivan Zanoni
Tristram A J Ryan
Mitochondrial tricarboxylic acid (TCA) cycle metabolites have emerged as critical regulators of immunity and inflammation beyond their canonical metabolic functions. During inflammatory responses, these metabolites accumulate to millimolar ...
The BAX/BAK apoptotic checkpoint polices entry to therapy-induced senescence [0.03%]
BAX/BAK凋亡检查点管控进入治疗诱导的衰老状态
Aislinn Gallagher Aldave,Vaishnavi Venugopalan,Gokhan Gunay et al.
Aislinn Gallagher Aldave et al.
Cytotoxic chemotherapy is intended to eliminate transformed cells but can also provoke therapy-induced senescence, a persistent and pro-inflammatory cell state that can promote tumor progression. The molecular mechanisms that govern the apo...
Repurposing simeprevir uncovers a druggable KPNB1-p65-BCL2 survival axis in cancer [0.03%]
再利用simeprevir发现癌症中可药用的KPNB1-p65-BCL2生存轴
Cong Li,Qiaohua Yan,Muhammad Muddasar Saeed et al.
Cong Li et al.
Proper subcellular protein localization is fundamental for protein function, yet cancer cells often exploit this machinery for survival. While the nuclear import receptor KPNB1 (importin β1) is overexpressed in various cancers, its oncogen...
Tae Ha Kim,Chi Thi Ngoc Nguyen,Dahee Jang et al.
Tae Ha Kim et al.
Coenzyme Q (CoQ) is an essential electron carrier and lipophilic antioxidant whose biological functions depend on its redox state. However, accurate measurement of reduced and oxidized CoQ is hindered by rapid ex vivo oxidation during sampl...
Logan Elkin,Evgeny G Chulkov,Jonathan D Enders et al.
Logan Elkin et al.
Benzodiazepines are widely prescribed therapeutics whose actions are primarily attributed to the modulation of GABAA receptors. Here, we identify a previously unrecognized target of a subset of benzodiazepines-the cold- and menthol-sensitiv...
A protective human antibody reveals a quaternary epitope on the Epstein-Barr virus fusion apparatus [0.03%]
一种具有保护作用的人类抗体揭示了爱泼斯坦-巴尔病毒融合装置上的四级表位
Ge-Xin Zhao,Xin-Yan Fang,Ting Li et al.
Ge-Xin Zhao et al.
Epstein-Barr virus (EBV) entry into B lymphocytes and epithelial cells requires the conserved fusion machinery gHgL and the tropism-switching glycoprotein gp42. While the individual roles of these proteins have been extensively studied, the...
Multinuclear iron enzymes expand RiPP chemical diversity to enable bacterial oxidative stress defense [0.03%]
多核铁酶使RiPP化学多样性多样化以增强细菌的氧化应激防御能力
Hanzhong Feng,Hang Xu,Zhuangzhuang Chu et al.
Hanzhong Feng et al.
RiPP structural complexity is significantly expanded by multinuclear non-heme iron-dependent oxidative enzymes (MNIOs). Here, we characterize pseudoprobactin 1 and 2, two MNIO-modified proteins from Pseudomonas protegens Pf-5. Using MS, NMR...