Quantitative profiling of RNA modifications enriched in non-membrane-bound cellular structures using APEX-RNA-MS [0.03%]
基于APEX-RNA-MS的非膜细胞器RNA修饰组定量分析方法
Kyung W Seo,Dhruv Y Dhingani,Ralph E Kleiner
Kyung W Seo
The dynamic behavior of RNAs underlies fundamental biological processes. RNA function is controlled by post-transcriptional modifications that are spatiotemporally regulated, but characterizing the distribution of modified RNA transcripts w...
Qingqing Chu,Yihang Li,Zeming Wu et al.
Qingqing Chu et al.
Increasing evidence suggests that epigenetic dysregulation is both a hallmark and a potential driving force of aging. As a multifactorial, non-linear, and systemic biological process, aging likely results from a progressive imbalance in a c...
Franklin L Nobrega
Franklin L Nobrega
In a paper recently published in Nature Microbiology, Banks et al.1 identify LypABC, a CARD-NLR-like module required for gene transfer agent (GTA) release in Caulobacter crescentus. The work uncovers an unexpected lysis pathway and suggests...
Ruonan Yang,Yanshan Fang
Ruonan Yang
S-acylation is well known for regulating protein stability and trafficking. In a recent issue of Molecular Cell, Xu et al.1 reveal a distinct, aggregation-suppressing function of this posttranslational lipid modification: S-acylation of the...
Intercepting the SOS message: SpsB inhibition by OXF-077 stalls the evolution of antibiotic resistance [0.03%]
拦截SOS信号：OXF-077通过抑制SpsB阻滞抗生素抗性进化
Marina Murillo-Torres,Sara Diaz-Diaz,José Manuel Rodríguez-Martínez
Marina Murillo-Torres
In this issue of Cell Chemical Biology, Bradbury et al.1 identify signal peptidase IB (SpsB) as the cellular target of the SOS-response inhibitor OXF-077. This uncovers an unexpected role for SpsB in bacterial mutagenesis, highlighting its ...
Extrabody: An optogenetic remote for extracellular antigen-driven cell behaviors [0.03%]
一种用于细胞外抗原驱动的细胞行为的光遗传学遥控器：ExtraBody
Zhenghua Wang,Yulong Li
Zhenghua Wang
In this issue of Cell Chemical Biology, Kwon et al.1 develop extrabody, a modular light-gated antibody platform that enables stimulus-dependent antigen recognition. By splitting surface-displayed antibodies into fragments that reassemble up...
Dangerous liaisons: Promiscuous inhibition of CHK1 and AMPK is a lethal affair for cancer cells [0.03%]
危险关系：CHK1和AMPK的非专一性抑制对癌细胞来说是致命的
Eudora L Lu,Kevin Nay,John W Scott
Eudora L Lu
In this issue of Cell Chemical Biology, Guo et al.1 reveal that the Checkpoint kinase 1 (CHK1) inhibitor Prexasertib moonlights as an AMP-activated protein kinase (AMPK) inhibitor that primes cancer cells for destruction. This off-target sy...
Signaling of glycoRNAs to Siglec-11 protects neurons by suppressing NF-κB [0.03%]
糖基RNA通过与Siglec-11信号传导抑制NF-κB从而保护神经元
Xingwen Wang,Jiahao Huang,Shangjie An et al.
Xingwen Wang et al.
Glycosylated RNAs (glycoRNAs), a class of extracellular glycosylated molecules, emerge as key regulators yet with undefined roles in neuroimmune communication. Through neuron-like and glia-like co-culture models, we identify a neuron's prot...
Pyroptosis across species and its potential impact on host defense against zoonotic pathogens [0.03%]
跨物种的焦亡及其对宿主防御人畜共患病原体的潜在影响
Stella Ho,Clare E Bryant
Stella Ho
Regulated cell death (RCD) plays a central role in host defenses against infection. It is also an important driver of pathology in sepsis. The proteins that regulate RCD in mice and, to a lesser degree, in humans are increasingly well under...
Small-molecule inhibitors of the protein kinase DYRK as potential therapeutic candidates in cancer [0.03%]
蛋白激酶DYRK的小分子抑制剂作为癌症治疗候选药物的潜力研究
Prabhadevi Venkataramani,Elad Elkayam,Ankur Garg et al.
Prabhadevi Venkataramani et al.
Dual-specificity tyrosine-regulated kinase 1A (DYRK1A) is crucial for normal brain development, and its disruption is linked to various cancers. DYRK1A drives glioblastoma (GBM) progression via stabilization of epidermal growth factor recep...