Ryan P McNamara
Ryan P McNamara
In this issue, McConnell et al.10 demonstrate that COVID-19 convalescent plasma (CCP)-derived antibodies can neutralize SARS-CoV-2 by proteolytically cleaving the spike protein. The CCP antibody-mediated catalysis has broader implications b...
TRIMming away colon cancer: TRIM21-mediated ubiquitination as an activator of the Hippo tumor suppressor pathway [0.03%]
通过TRIM21泛素化激活Hippo抑癌通路抑制结肠癌发生发展
Dorothy Benton,Jonathan Chernoff
Dorothy Benton
In this issue of Cell Chemical Biology, Liu et al.1 identify TRIM21-mediated ubiquitination of the Hippo pathway kinase MST2, promoting its dimerization and activation. The antidepressant Vilazodone was found to bind to TRIM21, enhancing it...
Endogenous anti-tumorigenic nitro-fatty acids inhibit the ubiquitin-proteasome system by directly targeting the 26S proteasome [0.03%]
内源性抗肿瘤硝基脂肪酸通过直接作用于26S蛋白酶体抑制泛素-蛋白酶体系统
Camilla Brat,Hai Phong Huynh Phuoc,Omar Awad et al.
Camilla Brat et al.
Nitro-fatty acids (NFAs) are endogenous lipid mediators causing a spectrum of anti-inflammatory effects by covalent modification of key proteins within inflammatory signaling pathways. Recent animal models of solid tumors have helped demons...
Hydroxyproline metabolism enhances IFN-γ-induced PD-L1 expression and inhibits autophagic flux [0.03%]
羟脯氨酸代谢增强IFN-γ诱导的PD-L1表达并抑制自噬体流动
Stephan H Spangenberg,Amelia Palermo,Nathalia R Gazaniga et al.
Stephan H Spangenberg et al.
The immune checkpoint protein PD-L1 plays critical roles in both immune system homeostasis and tumor progression. Impaired PD-1/PD-L1 function promotes autoimmunity and PD-L1 expression within tumors promotes immune evasion. If and how chan...
Chemokine binding to PSGL-1 is controlled by O-glycosylation and tyrosine sulfation [0.03%]
化学趋化因子与PSGL-1的结合受O-糖基化和酪氨酸硫酸化的控制
Christoffer K Goth,Akul Y Mehta,Alyssa M McQuillan et al.
Christoffer K Goth et al.
Protein glycosylation influences cellular recognition and regulates protein interactions, but how glycosylation functions alongside other common posttranslational modifications (PTMs), like tyrosine sulfation (sTyr), is unclear. We produced...
Terry C Yin,Jonathan G Van Vranken,Dhiraj Srivastava et al.
Terry C Yin et al.
Insulin resistance (IR) is the root cause of type II diabetes, yet no safe treatment is available to address it. Using a high throughput compatible assay that measures real-time translocation of the glucose transporter glucose transporter 4...
Genome- and metabolome-guided discovery of marine BamA inhibitors revealed a dedicated darobactin halogenase [0.03%]
基于基因组和代谢组的海洋BamA抑制剂发现以及鉴定特定靶向darobactin卤酶
Nils Böhringer,Jil-Christine Kramer,Eugenio de la Mora et al.
Nils Böhringer et al.
Darobactins represent a class of ribosomally synthesized and post-translationally modified peptide (RiPP) antibiotics featuring a rare bicyclic structure. They target the Bam-complex of Gram-negative bacteria and exhibit in vivo activity ag...
Proteome-wide structural analysis identifies warhead- and coverage-specific biases in cysteine-focused chemoproteomics [0.03%]
基于蛋白质组的结构分析发现了半胱氨酸靶向化学蛋白质组学中的弹头和覆盖范围特异性偏向性
Matthew E H White,Jesús Gil,Edward W Tate
Matthew E H White
Covalent drug discovery has undergone a resurgence over the past two decades and reactive cysteine profiling has emerged in parallel as a platform for ligand discovery through on- and off-target profiling; however, the scope of this approac...
Substrate-dependent interaction of SPOP and RACK1 aggravates cardiac fibrosis following myocardial infarction [0.03%]
缺血诱导的心肌纤维化中底物决定的SPOP和RACK1相互作用恶化了心肌纤维化
Wanqi Yang,Yuting Zhuang,Hao Wu et al.
Wanqi Yang et al.
Speckle-type pox virus and zinc finger (POZ) protein (SPOP), a substrate recognition adaptor of cullin-3 (CUL3)/RING-type E3 ligase complex, is investigated for its role in cardiac fibrosis in our study. Cardiac fibroblasts (CFs) activation...
Integrating inflammatory biomarker analysis and artificial-intelligence-enabled image-based profiling to identify drug targets for intestinal fibrosis [0.03%]
结合炎症生物标志物分析和人工智能辅助的基于图像特征分析识别肠纤维化药物靶点
Shan Yu,Alexandr A Kalinin,Maria D Paraskevopoulou et al.
Shan Yu et al.
Intestinal fibrosis, often caused by inflammatory bowel disease, can lead to intestinal stenosis and obstruction, but there are no approved treatments. Drug discovery has been hindered by the lack of screenable cellular phenotypes. To addre...