RENBP inhibition amplifies metabolic glycan labeling efficiency of antigen-presenting cells in vitro and in vivo [0.03%]
抑制RENBP可增强体内外抗原呈递细胞代谢性糖基化标记的效率
Yusheng Liu,Jiadiao Zhou,Yueji Wang et al.
Yusheng Liu et al.
Metabolic glycoengineering of unnatural sugars provides a powerful tool to introduce unique chemical tags onto cell membrane for subsequent conjugation of cargos. However, the metabolic glycan labeling efficiency of antigen-presenting cells...
Silencing stress: Structural insights into ISR termination by the SIFI ubiquitin ligase [0.03%]
ISG15通过SIFI E3连接酶介导的泛素样修饰终止内质网未折叠蛋白反应
Zeba Rizvi,Gabriel C Lander
Zeba Rizvi
The E3 ligase complex SIFI silences the integrated stress response (ISR) by targeting stress-induced proteins for degradation. In the May 6th issue of Nature, Yang et al.1 revealed how this megadalton complex recognizes diverse substrates a...
Powering the powerhouse: Mitochondrial NADPH propels oxidative metabolism [0.03%]
驱动代谢的引擎：线粒体NADPH促进氧化代谢
Riley J Wedan,Sara M Nowinski
Riley J Wedan
Mitochondrial NADPH is abundant, but the reason why was uncertain. In a study published in Nature Cell Biology, Kim et al.1 identified an important role of NADK2-derived mitochondrial NADPH in mitochondrial fatty acid synthesis (mtFAS) thro...
RPL22 links ribosome biogenesis, RNA splicing, and sensitivity to RNA polymerase I inhibition [0.03%]
RPL22连接核糖体生成、RNA剪接及RNA聚合酶I抑制敏感性
Kenyon Weis,Omar Abdel-Wahab
Kenyon Weis
In this issue of Cell Chemical Biology, Fan et al.1 identify that mutations in the ribosomal protein RPL22 confer sensitivity to RNA polymerase I inhibitors. RPL22 regulates MDM4 function and cell death via splicing of the MDM4 mRNA. These ...
A cereblon-based glue degrader of NEK7 regulates NLRP3 inflammasome in a context-dependent manner [0.03%]
一种基于CBL的NEK7胶水降解物以依赖于环境的方式调节NLRP3炎症小体
Aude Sylvain,Natacha Stoehr,Fupeng Ma et al.
Aude Sylvain et al.
Aberrant NLRP3 (NACHT-, leucine-rich repeat [LRR]- and pyrin domain [PYD]- containing protein 3) inflammasome activation is linked to many inflammatory diseases, driving the search for therapeutics inhibiting this pathway. NEK7 is proposed ...
Covalent inhibition of ACSL4 alleviates ferroptosis-induced acute liver injury [0.03%]
ACSL4的共价抑制缓解了铁死亡诱导的急性肝损伤
Maoyuan Linghu,Xianyu Luo,Xinru Zhou et al.
Maoyuan Linghu et al.
Ferroptosis, a form of regulated cell death, is characterized by iron-dependent phospholipid peroxidation and is closely linked to various liver diseases. Although covalent inhibitors have gained attention for their high potency and prolong...
Plasmodiumfalciparum protein kinase 6 and hemozoin formation are inhibited by a type II human kinase inhibitor exhibiting antimalarial activity [0.03%]
一种II型人激酶抑制剂通过抑制蛋白激酶6和疟原虫血红素晶格的形成而表现出抗疟活性
Flore Nardella,Tiantian Jiang,Lushun Wang et al.
Flore Nardella et al.
Kinase inhibitors are potent therapeutics, but most essential Plasmodium kinases remain unexploited as antimalarial targets. We identified compound 12, a type II kinase inhibitor based on aminopyridine and 2,6-benzimidazole scaffolds, as a ...
Ricardo Moreno-Ballesteros,Thomas Pembridge,Gaurav Beniwal et al.
Ricardo Moreno-Ballesteros et al.
Induced proximity using small molecules, exemplified by targeted protein degradation (TPD), represents a highly promising therapeutic strategy with significant untapped potential. However, evaluating an induced proximity event that accurate...
Ribosomal RNA transcription regulates splicing through ribosomal protein RPL22 [0.03%]
核糖体RNA转录通过核糖体蛋白RPL22调节剪接
Wenjun Fan,Hester Liu,Gregory C Stachelek et al.
Wenjun Fan et al.
Ribosome biosynthesis is a cancer vulnerability targeted by inhibiting RNA polymerase I (Pol I) transcription. We developed specific Pol I inhibitors that activate a ribotoxic stress pathway to uncover drivers of sensitivity. Integrating mu...
Flush with insight: Decoding GPCR crosstalk in the spinal defecation center [0.03%]
思路开阔：解码脊髓排便中心的GPCR信号串话现象
Nil Casajuana-Martin,Eli F McDonald,M Madan Babu
Nil Casajuana-Martin
G protein-coupled receptors (GPCRs) are increasingly recognized as part of interconnected, cell-context-specific signaling networks. In the June 5th issue of Molecular Cell, Dehkhoda et al.1 demonstrate that the constitutive activity of the...