A cereblon-based glue degrader of NEK7 regulates NLRP3 inflammasome in a context-dependent manner
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Aberrant NLRP3 (NACHT-, leucine-rich repeat [LRR]- and pyrin domain [PYD]- containing protein 3) inflammasome activation is linked to many inflammatory diseases, driving the search for therapeutics inhibiting this pathway. NEK7 is proposed to mediate NLRP3 inf... ...
