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RPL22 links ribosome biogenesis, RNA splicing, and sensitivity to RNA polymerase I inhibition

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In this issue of Cell Chemical Biology, Fan et al.1 identify that mutations in the ribosomal protein RPL22 confer sensitivity to RNA polymerase I inhibitors. RPL22 regulates MDM4 function and cell death via splicing of the MDM4 mRNA. These findings connect rib... ...