Scalable metal-organic framework membranes through nonclassical crystallization for molecular separation [0.03%]
基于非经典结晶的金属有机骨架膜的可控制备及其分子分离应用
Dongchen Shi,Fen Huang,Kai Xue et al.
Dongchen Shi et al.
Structurally ordered metal-organic framework (MOF) membranes hold great promise for selective molecular separations in chemical and pharmaceutical industries due to their precise pore size control and strong stability in organic solvents. H...
EphB1-NR2B receptor signaling in glutamatergic neurons of the ventroposteromedial thalamic nucleus regulates emergence from anesthesia [0.03%]
腹后内侧丘脑谷氨酸能神经元的EphB1-NR2B受体信号通路调控意识觉醒
Yuexin Liu,Jiang-Jian Hu,Boxu Cao et al.
Yuexin Liu et al.
Understanding the brain's intrinsic mechanisms that drive the emergence of consciousness from anesthesia remains a substantial and unresolved challenge in brain research. Here, we show in mice that, when the brain is forced into a minimal r...
Forced bond ionization-driven design of ultralow lattice thermal conductivity materials for flexible thermoelectrics [0.03%]
强制性键离子化驱动的超低晶格热导率材料设计用于柔性温差发电材料
Shunda Yang,Lan Li,Chensheng Lin et al.
Shunda Yang et al.
The search for development strategies that yield low κlat has become the focus of thermoelectrics and barrier coatings. Here, we propose a "forced bond ionization" strategy by integrating conflicting coordination environments (planar three...
Human selection maintains karyotype integrity of highly unstable genomic cultivated autotetraploid potato (Solanum tuberosum) [0.03%]
人工选择维持高度不稳定的四倍体栽培马铃薯(Solanum tuberosum)染色体稳定性的机制研究
Lu Yang,Yanbo Bai,Getu Chao et al.
Lu Yang et al.
Understanding meiotic and genomic stability in polyploid species is critical for advancing genetic discovery and breeding. Potato (Solanum tuberosum), the third most important food crop globally, is represented by cultivated potato, an auto...
Integrating single-cell biophysical and transcriptomic features to resolve functional heterogeneity in mantle cell lymphoma [0.03%]
整合单细胞生物物理和转录组特征以解析套细胞淋巴瘤的功能异质性
Ye Zhang,Lydie Debaize,Adam Langenbucher et al.
Ye Zhang et al.
Intratumor heterogeneity impacts disease progression and therapeutic resistance but remains poorly characterized by conventional histologic, immunophenotypic, and molecular approaches. Single-cell biophysical properties distinguish function...
Programmable multistep CRISPR gene activation via control of RNA polymerase III termination [0.03%]
通过控制RNA聚合酶III终止实现可编程的多步CRISPR基因激活
Anupama K Puppala,Andrew C Nielsen,Maureen Regan et al.
Anupama K Puppala et al.
Although genomes encode instructions for mammalian cell differentiation with rich syntactic relationships, existing methods for genetically programming cells have only modest capabilities for stepwise gene regulation. Here, we develop a seq...
A self-assembled nano micelle-exosome with high selectivity and penetrability achieves precise intracartilage lipid delivery [0.03%]
一种能够实现软骨内部精准递送的高效渗透和高选择性自组装纳米胶束-外泌体复合系统
Ming-Yang Li,Li-Min Wu,Hui-Qi Xie et al.
Ming-Yang Li et al.
To address the challenge of extremely low drug bioavailability in osteoarthritis (OA) cartilage, we developed a self-assembled micelle-exosome system (Mic-Exo) tailored to the specific characteristics of OA cartilage. The hydrophobic lipid ...
Quantum-inspired computational wavefront shaping enables turbulence-resilient distributed aperture synthesis imaging [0.03%]
量子启发的计算波前整形赋能湍流环境下的分布式孔径合成成像
Shuai Sun,Zhen-Wu Nie,Yao-Kun Xu et al.
Shuai Sun et al.
Wavefront shaping is essential for optical imaging through aberrations, but conventional methods rely on physical modulators and iterative optimization, hindering real-time applications in dynamic environments like turbulence. Inspired by q...
VTA dopaminergic neuronal activity during NREM sleep is modulated by learning and facilitates motor memory consolidation [0.03%]
学习调节中脑多巴胺能神经元在慢波睡眠的活动并促进运动记忆巩固
Bibi Alika Sulaman,Eric Chen,Aaron Crane et al.
Bibi Alika Sulaman et al.
Memory consolidation enables animals to draw on past experiences to guide future behavior. This process involves system- and synaptic-level changes and predominantly occurs during sleep. While hippocampal-cortical circuits are well studied ...
Chengtao Sun,Dawei Li,Wenhe Liao et al.
Chengtao Sun et al.
Inspired by ancient chain mail, we introduce a stealth skin constructed from topologically interlocking units that synergizes mechanical robustness with electromagnetic functionality. This architecture is lightweight, highly conformable to ...