Engineered heart-liver axis nanoregulators synergize autophagy activation and systemic metabolic reprogramming against atherosclerosis [0.03%]
工程化的心肝轴纳米调控剂协同激活自噬和全身代谢重编程对抗动脉粥样硬化
Yiyong Tang,Jiadi Liu,Liya Tian et al.
Yiyong Tang et al.
Atherosclerosis (AS) is the most important pathological basis for cardiovascular diseases worldwide. However, the current mainstream therapeutic strategies for AS only target isolated pathological links, ignoring hepatic steatosis as a rela...
Genetic screening identifies WNT5A/RYK as a determinant of extracellular vesicle fate [0.03%]
基因筛选鉴定出WNT5A/RYK是细胞外囊泡命运的决定因素
Julia Dancourt,Satish Babu Moparthi,Jeanne Lainé et al.
Julia Dancourt et al.
Extracellular vesicles (EVs) are natural mediators of intercellular communication through the transfer of cytoplasmic material from donor to recipient cells. The molecular mechanisms governing EV uptake and cargo delivery in recipient cells...
Ji-Hyung Lee,Kiran Kumar Nakka,Ryan P Calhoun et al.
Ji-Hyung Lee et al.
Stem cell-mediated regeneration is essential for tissue integrity. In skeletal muscle, tissue repair largely depends on muscle stem cells (MuSCs), which undergo dynamic cell-state transitions through making precise fate decisions during reg...
Scalable human neuronal models of tauopathy producing endogenous seed-competent 4R tau [0.03%]
产生内源性4外显子tau的可扩展的人类神经元tau病模型
Eliona Tsefou,Sumi Bez,Timothy J Y Birkle et al.
Eliona Tsefou et al.
The accumulation of pathological four-repeat (4R) tau is central to several frontotemporal dementia (FTD) subtypes, but human neuronal models amenable to high-throughput screening of 4R tau-targeting therapies remain very limited. To addres...
sPLA2-reacted extracellular vesicles (SPLEVs) as a therapeutic modality for cytokine storm syndromes [0.03%]
sPLA2反应的细胞外囊泡（SPLEVs）作为细胞因子风暴综合征的治疗手段
Shunya Nakayama,Akane Kanamori,Takeshi Kamakura et al.
Shunya Nakayama et al.
Because cytokine storm syndromes such as sepsis, acute respiratory distress syndrome (ARDS), and coagulopathy, including those seen in COVID-19, are fatal, development of highly effective therapeutics is urgently needed. Recent evidence sug...
Dendritic cell circadian clocks shape memory CD8+ T cell differentiation [0.03%]
树突状细胞的昼夜钟调控记忆CD8⁺T细胞分化
Ward Vleeshouwers,Suzanne van Duikeren,J Fréderique de Graaf et al.
Ward Vleeshouwers et al.
Circadian rhythms regulate diverse immune processes, yet how they influence memory CD8+ T cell differentiation remains unclear. Here, we show that the time of day of antigen encounter shapes CD8+ T cell fate and antiviral immunity. Immuniza...
Zoltán Taracsák,Tamsin A Mather,Terry Plank et al.
Zoltán Taracsák et al.
Sulfur plays a critical role in modulating redox cycling on Earth. Yet, sulfur's behavior during subduction and in mantle redox reactions is debated. We analyzed 34S/32S in mafic arc melt inclusions from contrasting subduction zones and mod...
Human-inspired time-series health evaluation with an adaptive multimodal electronic skin [0.03%]
一种自适应多模态电子皮肤的人体启发的时序健康评估方法
Changhao Xu,Hongkai Zheng,Wenzheng Heng et al.
Changhao Xu et al.
Electronic skin powered with artificial intelligence could enable next-generation robotic and medical devices, yet integrating multimodal sensors and analyzing heterogeneous, multifrequency time series remain challenging. Most wearable mach...
Programming angiogenesis with tunable assemblies of multifunctional peptides [0.03%]
使用多功能肽的调节组件编程血管生成
Joseph Dodd-O,Bobak Shadpoor,Abhishek Roy et al.
Joseph Dodd-O et al.
Therapeutic angiogenesis is constrained by the inability to localize, sustain, and finely tune vascular signaling. Here, we detail a supramolecular peptide system that enables angiogenic programming by decoupling mechanical integrity from r...
Harrison P Lisabeth,Nicholas Schmerr,Matthew Siegler
Harrison P Lisabeth
Identifying water ice deposits on the Moon is critical for enabling long-term scientific investigations and supporting future lunar infrastructure. Although multiple lines of evidence suggest that substantial quantities of poleward water ex...