Prognostic stratification in non-small cell lung cancer using a TIDE-informed transcriptomic signature: model development and validation [0.03%]
基于TIDE的转录组特征在非小细胞肺癌预后分层中的应用：模型建立及验证
Jiaxuan Zhou,Na Li,Zimeng Li et al.
Jiaxuan Zhou et al.
Background: Non-small cell lung cancer (NSCLC) remains a major cause of cancer mortality. The Tumor Immune Dysfunction and Exclusion (TIDE) score is widely used to estimate immune-checkpoint blockade response, but its bro...
GPR176 represses mitophagy to promote the progression of osteosarcoma by facilitating mTORC1 activity via PI3K-AKT pathway [0.03%]
GPR176通过PI3K-Akt通路促进mTORC1活化从而抑制线粒体自噬来促进骨肉瘤的发生发展
Jiyong Jiang,Bowen Zheng,Jing Wang et al.
Jiyong Jiang et al.
Background: Osteosarcoma (OS) is a common primary malignant tumor of the bone. It is reported that abnormal GPR176 expression contributes to the occurrence and subsequent progression of tumors. However, the role of GPR176...
Prognostic value of DNA methylation in head and neck cancer: a systematic review and meta-analysis [0.03%]
头颈部癌症中DNA甲基化的预后价值：系统回顾和meta分析
Mingyang Che,Dongyuan Tang,Rongjun Zhang
Mingyang Che
Background: The clinical relevance of DNA methylation in head and neck cancer (HNC) is increasingly recognized, yet controversies persist regarding its prognostic significance. We conducted a systematic review and meta-an...
New model for remote symptom management and self-care of cancer patients based on digital health platforms: a narrative review [0.03%]
基于数字健康平台的远程癌症患者症状管理和自我护理新模式：叙述性文献回顾
Wen Chen,Yue Deng,Di Zhu et al.
Wen Chen et al.
Background and objective: With the increasing global cancer burden and prolonged survival of patients, effective post-treatment symptom management and self-care have become essential components of chronic cancer care. Tra...
IGF2BP3-mediated stabilization of RHOA mRNA promotes osteosarcoma proliferation via Hippo signaling [0.03%]
IGF2BP3通过稳定RHOA mRNA促进Hippo信号通路介导的骨肉瘤增殖
Jingbin Wu,Jiahao Xia,Yuan Tao et al.
Jingbin Wu et al.
Background: Osteosarcoma (OS) is the most common primary bone malignancy with an incompletely understood pathogenesis. The RNA-binding protein (RBP) insulin-like growth factor 2 messenger RNA (mRNA)-binding protein 3 (IGF...
Cinobufotalin reduces glioblastoma resistance to temozolomide by inhibiting the CCL5-mediated PI3K/Akt/mTOR signaling pathway [0.03%]
灯台叶醇减少端粒酶阳性胶质瘤细胞化疗耐药性研究
Jiwei Sun,Xianyuan Ma,Jian Song et al.
Jiwei Sun et al.
Background: Temozolomide (TMZ) resistance is a key factor that restricts the therapeutic effects of glioblastoma (GBM). The pharmacological properties of cinobufotalin (CB) indicated that CB promotes the cell death of GBM...
Programmed cell death receptor 1 inhibitors combined with paclitaxel-platinum induction chemotherapy for treating patients with locally advanced nasopharyngeal carcinoma: a real-world retrospective study [0.03%]
程序性细胞死亡配体1抑制剂联合紫杉醇-铂类诱导化疗治疗局部晚期鼻咽癌患者的真实世界回顾性研究
Lilan Chen,Xing Song,Junjun Chen et al.
Lilan Chen et al.
Background: Concurrent chemoradiotherapy (CCRT) combined with induction chemotherapy (IC) is the standard first-line treatment for locally advanced nasopharyngeal carcinoma (LA-NPC). However, treatment-related toxicities ...
Inhibition of proliferation and metastasis of nasopharyngeal carcinoma by kaempferol via down-regulation of c-Jun [0.03%]
山柰酚通过下调c-Jun抑制鼻咽癌的增殖和转移
Sihai Dai,Yanqing Zheng,Yue Xu et al.
Sihai Dai et al.
Background: Nasopharyngeal carcinoma (NPC) is a highly aggressive malignancy of the head and neck, characterized by poor therapeutic outcomes. Kaempferol (Kae) has demonstrated significant potential in curbing tumor proli...
Multimodal approach for the comprehensive management of non-small cell lung cancer: a case report [0.03%]
非小细胞肺癌综合治疗的多模式方法个案报告
Jincai Zhou,Kai Ma,Xinpeng Han et al.
Jincai Zhou et al.
Background: Lung squamous cell carcinoma (LSCC) is a common malignant tumor with a high incidence rate and poses a serious threat to patients' health and quality of life. This case reports the complex diagnosis and treatm...