Activated CD38+ mast cells promote gastric cancer progression by suppressing CD8+ T cell cytotoxic activity through adenosine metabolism [0.03%]
活化的CD38+肥大细胞通过腺苷代谢抑制CD8+T细胞毒性作用促进胃癌进展
Jiabao Zhao,Deyi Feng,Fan Zhang et al.
Jiabao Zhao et al.
Helicobacter pylori (H. pylori) infection is the primary driver in gastric cancer (GC) development, but the dynamic changes of the gastric mucosal microenvironment during H. pylori-associated GC progression remains elusive. Here, we perform...
Thyroid hormone augmentation accelerates hair cell maturation in human cochlear organoids [0.03%]
甲状腺激素增强可加速人体耳蜗类器官毛细胞成熟
Tsubasa Saeki,Yoshitomo Ueda,Isabel Aristizábal-Ramírez et al.
Tsubasa Saeki et al.
Human pluripotent stem cell-derived cochlear organoids are promising tools for studying human cochlear development and disease. However, the maturation of hair cells in these organoids is slow, requiring 200 days to express the mature outer...
Airway injury induces alveolar epithelial responses mediated by macrophages [0.03%]
气道损伤通过巨噬细胞介导的上皮反应诱导肺泡上皮反应
Irene G Wong,Margherita Paschini,Jillian Stark et al.
Irene G Wong et al.
Airway injury activates local progenitors and stimulates cell-cell interactions to restore homeostasis, but it is unknown how distal niches are impacted. We utilized mouse models of airway-specific epithelial injury to examine secondary tis...
Lateral habenula and periaqueductal gray neurons signal reward prediction error and continuity of reward expectancy to drive reward-seeking behavior [0.03%]
外侧缰核和导水管周围灰质神经元通过信号传导奖励预测误差和预期的连续性来驱动觅奖行为
Hyunchan Lee,Okihide Hikosaka
Hyunchan Lee
Reward-seeking behaviors often require not only encoding moment-to-moment reward prediction errors but also sustaining reward expectancy in the face of repeated negative outcomes and ongoing effort costs. While the lateral habenula has been...
Integrative multi-omics analysis reveals oral microbiome-metabolome signatures of obesity [0.03%]
整合多组学分析揭示了肥胖相关口腔微生物组-代谢组标志物
Ahmed A Shibl,Tsedenia W Denekew,Anique R Ahmad et al.
Ahmed A Shibl et al.
Obesity is a leading global health challenge and risk factor for cardiometabolic disorders, driven in part by industrialization and low-fiber, ultra-processed diets. While the gut microbiome has been implicated in obesity, the contribution ...
Lysosome-localized IRTKS condensates promote mTORC1 activity leading to MASLD and HCC [0.03%]
溶酶体定位的IRTKS凝聚物通过促进mTORC1活性导致MASLD和HCC
Chenyi Xie,Xiaofang Cui,Wei Wei et al.
Chenyi Xie et al.
Metabolic dysregulation has been recognized as a crucial driver of tumorigenesis, particularly in metabolic dysfunction-associated steatotic liver disease (MASLD)-related hepatocellular carcinoma (HCC). However, the underlying mechanisms re...
Myomaker and ether lipids cooperate to promote fusion-competent membrane states [0.03%]
肌球蛋白和醚脂质合作促进融合兼容的膜状态
Tanner J Wherley,Xueheng Zhao,Sajedah M Hindi et al.
Tanner J Wherley et al.
Cell fusion is a fundamental process for skeletal muscle development and regeneration. The muscle-specific fusogens Myomaker and Myomerger are necessary for fusion of muscle cells and together are sufficient for fusion. A mechanistic unders...
Stress resilience is associated with transcriptional remodeling in the VTA [0.03%]
压力耐受与中脑腹侧被盖区转录重构相关
Adelaide R Minerva,Brenna McMannon,Rixing Lin et al.
Adelaide R Minerva et al.
Individual responses to chronic stress vary, with some individuals remaining resilient while others exhibit susceptibility. Here, we use single-nucleus RNA sequencing to understand molecular adaptations in the ventral tegmental area (VTA) a...
Retinal determination network reactivation drives chemoresistance and blocks myeloid differentiation in acute myeloid leukemia [0.03%]
视网膜决定网络的重新激活驱动急性髓系白血病化疗耐药并阻滞髓样分化
Liam Clayfield,Divya Malik,Jessica Whittle et al.
Liam Clayfield et al.
Acute myeloid leukemia (AML) is a heterogeneous malignancy driven by abnormal transcriptional programs that block myeloid differentiation and sustain self-renewal. Despite treatment advances over the last 30 years, refractory responses rema...
Polystyrene nanoplastics readily penetrate intestine and cause sex-specific effects mediated by bile acids and microbiome [0.03%]
聚苯乙烯纳米塑料可轻易穿透肠道并引起胆汁酸和肠道微生物群介导的性别差异效应
Jing Li,Zeyan Li,Qixue Bao et al.
Jing Li et al.
Orally ingested nanoplastics can enter the blood flow; however, their digestive tract fate is unclear. We found that ∼60% of ingested polystyrene nanoparticles (PSNPs) cross the intestine wall in 3 h, but most are captured by the liver and...