Cortical astrocytic neogenin, a key protein switching HIF1/2ɑ-VEGFa-induced angiogenesis to MEGF10-driven phagocytosis [0.03%]
皮质星形胶质细胞间质蛋白，在HIF1/2ɑ-VEGFa诱导的血管生成转换为MEGF10驱动的吞噬作用中起关键作用
Ling-Ling Yao,Daehoon Lee,Min-Yi Wu et al.
Ling-Ling Yao et al.
Astrocytes coordinate vascular homeostasis and tissue clearance in the brain, yet how these functions are mechanistically integrated remains unclear. Here, we identify neogenin (NEO1) as a cortex-specific astrocytic regulator that links ang...
Mitochondrial transfer to granulocytic myeloid-derived suppressor cells augments immunosuppressive activity [0.03%]
线粒体转移至髓样源性抑制细胞可增强其免疫抑制功能
Prabhakar Arumugam,Cortney E Heim,Rachel W Fallet et al.
Prabhakar Arumugam et al.
The anti-inflammatory properties of granulocytic myeloid-derived suppressor cells (G-MDSCs) promote Staphylococcus aureus (S. aureus) biofilm persistence. Evidence suggests that G-MDSC activity is shaped not only by S. aureus products but a...
Unified phase separation drives DNA-induced inflammasome activation of the AIM2-like receptors [0.03%]
统一的相分离驱动DNA诱导的AIM2样受体炎性小体活化
Xiangyu Huang,Yufei Zhang,Zhenchao Zhao et al.
Xiangyu Huang et al.
AIM2-like receptors (ALRs) are critical for host defense by sensing intracellular foreign DNA and aberrant self-DNA to activate inflammasomes. Here, we demonstrate that both human and mouse AIM2 undergo liquid-liquid phase separation (LLPS)...
Glycogen and lactate metabolism in mouse fetal Sertoli cells sustain the germ line [0.03%]
小鼠生精细胞中糖原和乳酸代谢维持生殖细胞 lineage
Martín A Estermann,Joseph Sheheen,Sara A Grimm et al.
Martín A Estermann et al.
Metabolites are key regulators of cell fate decisions, chromatin remodeling, and lineage commitment. While genetic pathways governing testis differentiation are well studied, the role of metabolism remains poorly understood. In this study, ...
Steven H Phan,Mai Wang,Kayla R Snare et al.
Steven H Phan et al.
Heritable genetic changes continually arise in cancer, especially in solid tumors where cells are sometimes compressed. Rare heritable losses of chromosomes in live cells are quantified here with chromosome reporters (ChReporters), which re...
Targeting redundant gene families: A multiplexed, tissue-specific CRISPR toolbox for Arabidopsis genetic screens [0.03%]
针对冗余基因家族的多重组织特异性CRISPR工具应用于拟南芥遗传筛选研究
Moran Anfang,Reem Haj Yahya,Omer Caldararu et al.
Moran Anfang et al.
Genome-scale targeted CRISPR libraries for forward genetic screens in plants are powerful tools for functional analysis, but they suffer from limited spatial control, single sgRNA design, and poor handling of genetic redundancy. We develop ...
ADAR1 regulates dsRNA formation in nuclear and mitochondrial transcripts through editing-dependent and -independent mechanisms [0.03%]
ADAR1通过编辑依赖和非依赖机制调节核内和线粒体转录本中dsRNA的形成
Heegwon Shin,Tyler J Dorrity,Justin Aruda et al.
Heegwon Shin et al.
Endogenous (self) double-stranded RNAs (dsRNAs) in human cells can activate innate immune responses. ADAR1, an A-to-I editing enzyme of dsRNAs, suppresses aberrant immune activation by self-dsRNAs. However, how ADAR1 influences the cellular...
Repeated COVID-19 vaccine boosters elicit variant-specific memory B cells in humans [0.03%]
重复接种COVID-19疫苗可诱导人类产生针对变异株的特异性记忆B细胞
M Alejandra Tortorici,Kaitlin R Sprouse,Amin Addetia et al.
M Alejandra Tortorici et al.
The first exposure to a pathogen impacts subsequent immune responses toward related pathogens. This immune imprinting explains that infection or vaccination with circulating SARS-CoV-2 variants primarily recalls cross-reactive memory B cell...
Nucleic acid-induced NADase activation of a short Sir2-associated prokaryotic Argonaute system [0.03%]
核酸诱导的NAD酶激活与短Sir2相关原核Argonaute系统的相互作用
Dapeng Sun,Kaixiang Zhu,Linyue Wang et al.
Dapeng Sun et al.
Published Erratum
Cell reports. 2026 Mar 7;45(3):117172. DOI:10.1016/j.celrep.2026.117172 2026
Latexin regulates sex dimorphism in hematopoiesis via gender-specific differential expression of microRNA 98-3p and thrombospondin 1 [0.03%]
Latexin通过性别特异性差异表达的microRNA 98-3p和血小板源性生长因子受体相互作用蛋白THBS1调节造血系统的性别二态性
Xiaojing Cui,Cuiping Zhang,Fang Wang et al.
Xiaojing Cui et al.
Published Erratum
Cell reports. 2026 Mar 6;45(3):117153. DOI:10.1016/j.celrep.2026.117153 2026