Tgf-β receptor signaling cell-intrinsically controls conserved microglia homeostatic maturation during zebrafish development [0.03%]
tgf-β受体信号通过细胞内在机制控制斑马鱼发育过程中小胶质细胞稳态成熟过程中的保守性
Magali Miserocchi,Pauline De Meyer,Ruben Lattuca et al.
Magali Miserocchi et al.
Microglia, embryonically derived tissue-resident macrophages of the central nervous system, are essential for brain development, homeostasis, and disease. Although transforming growth factor β (TGF-β) signaling is required for mammalian m...
Stress granules confer an early vulnerability in KRAS-driven pancreatic tumorigenesis [0.03%]
KRAS驱动的胰腺肿瘤发生早期应激颗粒赋予的脆弱性
Matias Estaras,Emma Cosialls,Gareth Pollin et al.
Matias Estaras et al.
Pancreatic ductal adenocarcinoma (PDAC) is initiated by activating KRAS mutations, yet most pancreatic cells fail to survive the induced oncogenic stress. How a subset adapts to and initiates malignant transformation remains unclear. Here, ...
Distinct endogenous retroviruses are expressed in mutational subtypes of clear cell renal cell carcinoma and are linked to improved clinical outcomes [0.03%]
不同内源性逆转录病毒在透明细胞肾细胞癌突变亚型中的表达及其与良好临床结果的关系
Kevin Meli,Cora A Ricker,Sabrina Y Camp et al.
Kevin Meli et al.
Distinct mutations in chromatin regulators and aberrant expression of transposable elements (TEs), have been associated with clinical benefit to immunotherapy (IO) in specific clear cell renal cell carcinoma (ccRCC) clinical contexts. Howev...
Yan Wang,Yanping Hu,Zhenhang Chen et al.
Yan Wang et al.
SARS-CoV-2 BA.3.2 sublineages, derived from BA.3 and carrying substantial spike divergence, raised concerns about altered fitness and antigenicity. Using BA.3.2.1 as a representative strain, we engineered live-attenuated SARS-CoV-2 encoding...
ALIX Regulates Tumor-Mediated Immunosuppression by Controlling EGFR Activity and PD-L1 Presentation [0.03%]
Alix通过控制EGFR活性和PD-L1呈递来调节肿瘤介导的免疫抑制
James Monypenny,Hanna Milewicz,Fabian Flores-Borja et al.
James Monypenny et al.
Published Erratum
Cell reports. 2026 Aug 8;45(8):117882. DOI:10.1016/j.celrep.2026.117882 2026
Microglial APOE3 Christchurch protects neurons from Tau pathology in a human iPSC-based model of Alzheimer's disease [0.03%]
基于人诱导多能干细胞的阿尔茨海默病模型中，小胶质细胞APOE3Christchurch保护神经元免受tau病理损害
Guoqiang George Sun,Cheng Wang,Randall C Mazzarino et al.
Guoqiang George Sun et al.
Published Erratum
Cell reports. 2026 Aug 8;45(8):117853. DOI:10.1016/j.celrep.2026.117853 2026
Integrative single-cell eQTL and GWAS analyses identify cell-type-specific regulatory mechanisms underlying ESCC susceptibility [0.03%]
整合单细胞eQTL和GWAS分析识别与食管癌易感性相关的特定细胞类型的调控机制
Lina Song,Miaoxin Pan,Yueping Li et al.
Lina Song et al.
Interpreting genetic risk variants within their relevant cellular contexts remains a central challenge in esophageal squamous cell carcinoma (ESCC), a malignancy with a substantial inherited component. We integrate single-cell RNA sequencin...
Depletion of CARM1 slows in vivo tumorigenicity and rewires developmental programming in glioma stem-like cells [0.03%]
CARM1耗竭抑制胶质瘤干细胞的体内成瘤并重编程其发育分化方向
Dejauwne L Young,Stephanie Stransky,Maria G Molero et al.
Dejauwne L Young et al.
Glioma stem-like cells (GSCs) exploit developmental signaling programs that contribute to glioblastoma heterogeneity and therapy resistance. Here, we define a role for the arginine methyltransferase coactivator-associated arginine methyltra...
Diurnal regulation of Acyl-CoA synthetase 3 (ACSF3) governs rhythmic mitochondrial lysine-malonylation and daily hepatic metabolism [0.03%]
乙酰辅酶A合成酶3（ACCS3）的昼夜调节控制肝脏线粒体赖氨酸-丙二酸化的昼夜节律及每日肝代谢
Enora Le Questel,Charlène Besnard,Florian Atger et al.
Enora Le Questel et al.
Hepatic daily rhythms are coordinated by feeding and the molecular circadian clock, ensuring metabolic homeostasis. Disrupted feeding schedules promote circadian misalignment and metabolic diseases but the underlying mechanisms remain scarc...
IL-19+ monocytes suppress neuroinflammation and promote neurological recovery in young individuals with traumatic brain injury [0.03%]
IL-19+单核细胞通过抑制神经炎症促进年轻创伤性脑损伤患者的神经功能恢复
Zhichao Lu,Jingwei Zhao,Jue Zhu et al.
Zhichao Lu et al.
Young patients with traumatic brain injury (TBI) have a better prognosis than the aged, but the underlying mechanisms are not clear. Here, we identified a population of IL-19+ monocytes derived from cranial bone marrow appearing in the brai...