Jacob Kim,Shicong Xie,Lucas Fuentes Valenzuela et al.
Jacob Kim et al.
Cells maintain size homeostasis by coupling growth to division. In budding yeast, newborn cells contain similar amounts of the G1/S inhibitor Whi5, which is diluted as cells grow in G1 to promote cell cycle entry. Similar Whi5 amounts at bi...
Ebba K Blomqvist,Nicole Bracci,Helena Winstone et al.
Ebba K Blomqvist et al.
Protein kinase R (PKR) is a critical component of mammalian intracellular antiviral immunity. Here, we examine the process of PKR activation in response to Middle East respiratory syndrome coronavirus (MERS-CoV) and Zika virus (ZIKV) using ...
The mycobacterial ATP burst is a lysis artifact and serves as an assay for drug-induced cell wall damage [0.03%]
Claire V Mulholland,Bei Shi Lee,Alexander Chong et al.
Claire V Mulholland et al.
Antibiotics targeting the mycobacterial cell wall are a cornerstone of tuberculosis treatment, yet how these drugs facilitate bacterial killing remains incompletely understood. Studies using the BacTiter-Glo luminescence assay have reported...
Decoy antibodies block extracellular HSP70, prevent self-signaling, and inhibit melanoma cell survival [0.03%]
Noam Ben-Shalom,Shivang Parikh,Lilach Abramovitz et al.
Noam Ben-Shalom et al.
Melanoma cells secrete melanosomes, large extracellular vesicles that reinforce tumor growth and survival signaling. To determine whether these vesicles elicit functional humoral immunity, we immunized mice with melanoma-derived melanosomes...
Comprehensive mass spectrometry screening-derived atlas of HDAC inhibitors reveals histone-specific acetylation changes [0.03%]
Rashmi Karki,Francisca N De Luna Vitorino,Richard M Searfoss et al.
Rashmi Karki et al.
Histone deacetylase inhibitors (HDACis) have emerged as valuable therapeutics for cancer and other diseases; however, their effects on histone post-translational modification remain poorly characterized. Here, we applied quantitative mass s...
Irina Shchukina,Carlos J Rodriguez-Hernandez,Heather S Ruiz et al.
Irina Shchukina et al.
Aging strongly impacts CD8+ T cells, including the loss of naive cells and the emergence of age-associated GZMK+CD8+ T cells (TAA cells). Although TAA cells constitute a major population in aged mice, the pathway underlying their differenti...
A bioluminescence-based chemical screen identifies a bactericidal naphthalen-1-ylmethanamine scaffold targeting MmpL3 in Mycobacterium abscessus [0.03%]
Samsher Singh,Ria Sorayah,Yushu Chen et al.
Samsher Singh et al.
Treatment of Mycobacterium abscessus pulmonary disease (Mabs-PD) is a growing global health challenge. The lack of bactericidal antibiotics effective at therapeutically relevant concentrations underscores an urgent need for drug discovery. ...
Intralaminar thalamus relays basal ganglia output to the insular cortex to drive tic generation [0.03%]
Hiroto Kuno,Natsumi Tsuji,Kenta Kobayashi et al.
Hiroto Kuno et al.
Motor and vocal tics accompanied by premonitory urges are hallmark symptoms of Tourette syndrome (TS), yet the underlying neuronal mechanisms remain incompletely understood. Here, we establish a mouse model of tic-like movements by unilater...
Q&A with Hua Zhong [0.03%]
Hua Zhong
Hua Zhong
Hua Zhong spoke with Cell Reports about their scientific journey and their work on the neural and immunological mechanisms driving lung cancer progression; in particular, they discussed their lab's recent Cell Reports paper on the role of t...
M Á Luján,R Young-Morrison,V Kashtelyan et al.
M Á Luján et al.
Quickly adapting behavior to changing environments is key for survival. Brain dopamine signals reinforce actions that procure rewards and avoid adverse outcomes. However, the molecular mechanisms within the circuits that actuate these signa...