Microglial states associate with lesion dynamics in multiple sclerosis [0.03%]
少突胶质细胞状态与多发性硬化的病变动力学相关
Aletta M R van den Bosch,Jia Hui Khoo,Zhigang Lu et al.
Aletta M R van den Bosch et al.
Multiple sclerosis (MS) is a neuroinflammatory disease of the CNS characterized by demyelinating lesions. Lesion expansion contributes to disability progression, whereas remyelination may restore neurological function. How these divergent o...
Lateral habenula 5-HT4 receptor signaling restores social novelty preference after acute isolation [0.03%]
急性隔离后恢复社交新颖性偏好的缰侧核5-羟色胺4型受体信号机制
Miseon Kang,Sukwoon Song,Beomsue Kim et al.
Miseon Kang et al.
Social homeostasis-the maintenance of stable social contact-is disrupted by acute social stressors such as isolation. While the lateral habenula (LHb) is known for encoding negative emotional salience, it also modulates social behavior. How...
Collective cell migration plasticity in patient-derived digestive cancer organoids is dictated by environment sensing and contractility [0.03%]
患者来源的消化系肿瘤类器官的集体细胞迁移可塑性由环境感知和收缩性决定
Clémence Nguyen-Vigouroux,Elise Carraz-Billat,Tatiana Cetenovic et al.
Clémence Nguyen-Vigouroux et al.
The metastatic dissemination of individual cells or cell collectives is a decisive step in the progression of cancers. Migrating single cells dynamically switch between mesenchymal traction-based and amoeboid propulsion-based modes of migra...
The circadian clock component BMAL1 enhances macrophage inflammation by nuclear translocation of peroxisomal β-oxidation enzyme MFP2 [0.03%]
核转位的过氧化物酶体β氧化酶MFP2增强BMAL1昼夜节律钟组件对巨噬细胞的炎症作用
Akito Tsuruta,Nodoka Hirao,Megumi Shibata et al.
Akito Tsuruta et al.
The circadian clock regulates diverse immune functions, yet the role of clock components in macrophage inflammation remains controversial, with both pro- and anti-inflammatory effects reported. Here, we identify a previously unrecognized me...
Bilirubin mitigates ischemic white matter injury by targeting transferrin-receptor-mediated B cell immunometabolism [0.03%]
胆红素通过靶向转铁蛋白受体介导的B细胞免疫代谢缓解缺血性白质损伤
Lian Chen,Xiao-Wei Pang,Zhi-Cheng Mei et al.
Lian Chen et al.
Physiological bilirubin exerts protective effects against ischemic stroke, but its role in post-stroke white matter injury (WMI) remains unclear. Here, through integrated epidemiological, genetic, and mechanistic studies, we demonstrate tha...
B cell TET2 recruits OGT for nuclear TET2 and H2B O-GlcNAcylation to drive AID and BLIMP-1 expression and maturation of the antibody response [0.03%]
B细胞TET2招募OGT促进核内TET2和H2B O-GlcNAc酰化驱动AID及BLIMP-1表达和抗体应答的成熟
Shili Li,Yibo Peng,Zhimin Yang et al.
Shili Li et al.
Maturation of antibody responses entails B cell Aicda/AID and Prdm1/BLIMP-1 expression for SHM/CSR, plasma cell differentiation, and production of class-switched high-affinity antibodies. We determined that TET1, TET2, and TET3 are not expr...
Coordinated regulation of mRNA translation and stability by ZC3H7A and ZC3H7B RNA-binding proteins [0.03%]
RNA结合蛋白ZC3H7A和ZC3H7B对蛋白质翻译和mRNA稳定性的协调调控作用
Patric Harris Snell,Parisa Naeli,Aitor Garzia et al.
Patric Harris Snell et al.
mRNA translation and stability are tightly regulated and functionally linked through cis-acting sequence elements and trans-acting factors, including RNA-binding proteins (RBPs). Here, we report that two chordate-specific paralogous RBPs, Z...
The MLLT3 YEATS domain binds histone marks (H3K9/18/27ac/cr) and ncRNA (7SK), linking transcription and RNA signaling to regulate hematopoiesis [0.03%]
MLLT3YEATS结构域结合组蛋白修饰(H3K9/18/27ac/cr)和ncRNA(7SK)，连接转录与RNA信号传导以调控血液发育
Adam Boulton,Ashish Kabra,Nicholas Achille et al.
Adam Boulton et al.
MLLT3 (AF9) is a critical regulator of hematopoiesis. The YEATS domain of MLLT3 binds to acylated histones (H3K9ac/cr). We showed that the YEATS domain also binds to RNA. PAR-CLIP data demonstrated binding to the snRNA 7SK. Biochemical stud...
RNA-programmable cell-type monitoring and manipulation in the human cortex with CellREADR [0.03%]
具有CellREADR的RNA编程的人脑皮层细胞类型监测和操作技术
Elizabeth A Matthews,Jeffrey B Russ,Yongjun Qian et al.
Elizabeth A Matthews et al.
Published Erratum
Cell reports. 2026 Jun 10;45(6):117589. DOI:10.1016/j.celrep.2026.117589 2026
Peptide-MHC-targeted engineered virus-like particles enable selective priming and gene editing of tumor-specific T cells [0.03%]
针对肽-MHC的工程病毒样颗粒能够选择性地激活并进行基因编辑以识别肿瘤抗原的T细胞
Brian H Shim,Q Henry Zhao,Jack A Queenan et al.
Brian H Shim et al.
Tumor-infiltrating lymphocyte (TIL) therapies harness tumor-specific T cells endogenous to a patient's repertoire but their efficacy is limited by challenges such as low frequencies of tumor-specific clonotypes and dysfunctional T cell phen...