Herbivory leaves a soil-borne defensive legacy that recruits parasitoids [0.03%]
食草作用留下了一种土壤介导的防御遗产，从而招募了寄生虫
Yang Gao,Hainuo Hong,Qiulin Chen et al.
Yang Gao et al.
How organisms convert short-term stress into long-term defense is a key ecological question. Classic herbivore-induced plant volatiles recruit natural enemies but act briefly only in damaged tissues. Here, we report that leaf herbivory esta...
Type I interferon-activated myeloid states are associated with less fibrotic stages in idiopathic pulmonary fibrosis [0.03%]
I型干扰素激活的髓样细胞状态与特发性肺纤维化较不严重的纤维化阶段相关
Vishal Nathwani,Praveen Weeratunga,Jeongmin Woo et al.
Vishal Nathwani et al.
Early immune processes in idiopathic pulmonary fibrosis (IPF) are poorly defined. Here, we integrate single-cell transcriptomics of lung digests and bronchoalveolar-lavaged cells (n = 108 patients), subcellular-resolution tissue spatial tra...
Sparse input representations explain odor discrimination in complex, concentration-varying mixtures [0.03%]
稀疏输入表示解释了复杂浓度变化混合物中的气味辨别能力
Hannah McCalmon,George Cai,Constantine Tsibouris et al.
Hannah McCalmon et al.
In natural environments, animals must detect behaviorally relevant odors despite variability in both odor mixture composition and stimulus intensity. Although mice can identify salient odors embedded in complex mixtures, how target concentr...
Promoter variation of COG5 underlies subspecies divergence in rice chilling tolerance [0.03%]
COG5启动子变异影响水稻耐寒性亚种差异
Shuangshuang Zheng,Zhitao Li,Yibin Li et al.
Shuangshuang Zheng et al.
Chilling stress severely threatens rice productivity. While multiple signaling pathways in chilling tolerance have been elucidated, the role of the Mediator complex in this process remains poorly understood. Here, we identify COG5, a major ...
Retrosplenial cortex maturation aligns with the transition from infant forgetting to persistent memory [0.03%]
视皮质后部成熟度与从婴幼儿健忘向持久性记忆转变的关系研究
Benita Jin,Abigail L Yu,Michael W Gongwer et al.
Benita Jin et al.
Memories formed early in life are rapidly forgotten, whereas those formed later persist. Recent work revealed that physical traces of infant memories endure in the brain but are inaccessible to natural recall. However, the developmental pro...
Adaptive variation in butyrylcholinesterase-influenced lipid metabolism during horse domestication [0.03%]
马驯化过程中受乙酰胆碱酯酶影响的脂质代谢的适应性变异
Yanli Zhang,Xuexue Liu,Xintong Wang et al.
Yanli Zhang et al.
Lipid metabolism influences horse athletic performance, yet its genetic basis remains unclear. Here, we investigate the genetic basis of lipid metabolic traits by quantifying key metabolic parameters and sequencing the genomes of 298 horses...
Elevated neuronal TAF15 expression induces oxidative stress and anxiety-related behavioral deficits [0.03%]
神经元TAF15表达上调会诱导氧化应激和与焦虑相关的行为缺陷
Tuo Yi,Haoyuan Guan,Jun Li et al.
Tuo Yi et al.
TAF15 is a DNA/RNA-binding protein involved in RNA processing whose dysfunction has been implicated in neurodegenerative diseases, including frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). However, the relationship be...
Newborn neurons compete with neuronal ensembles to moderate behavioral responses to stress [0.03%]
新生神经元与神经回路竞争调节应激引起的行为反应
Can-Yuan Zhang,Su-Fen Wei,Ya-Ping Wang et al.
Can-Yuan Zhang et al.
Newborn neurons in the adult hippocampal dentate gyrus (DG) are hyperexcitable, competitive cells involved in behavioral responses to stress and antidepressants. The role and the mechanisms underlying the competitiveness of the newborn neur...
Hcp1 mediates multinucleated giant cell formation through redirecting arginine metabolism during Burkholderia pseudomallei infection [0.03%]
Burkholderia pseudomallei感染通过Hcp1介导的精氨酸代谢重编程促进多核巨细胞形成
Pan Wu,Beibei Fu,Dongqi Nan et al.
Pan Wu et al.
Melioidosis is a life-threatening infectious disease caused by Burkholderia pseudomallei with limited therapeutic options. Multinucleated giant cell (MNGC) formation is known to facilitate B. pseudomallei dissemination and melioidosis progr...
SPINK1-COL18A1 crosstalk shapes epigenome and drives cancer stemness in pancreatic ductal adenocarcinoma [0.03%]
SPINK1-COL18A1互作重塑表观遗传调控图谱并促进胰腺导管腺癌干细胞特性
Haoyu Tang,Bethsebie Sailo,Xingbo Shang et al.
Haoyu Tang et al.
Pancreatic ductal adenocarcinoma (PDAC) is a devastating cancer with increasing incidence and a dismal prognosis. Here, we uncover serine protease inhibitor Kazal type 1 (SPINK1) as a putative determinant of PDAC progression with a previous...