Micro- and nanoplastics facilitate the propagation of antimicrobial resistance in mixed microbial consortia [0.03%]
微塑料和纳米塑料促进混合微生物群中抗菌药物抗性的传播
Jianyuan Zhen,Wei Wei,Haoran Duan et al.
Jianyuan Zhen et al.
Navigating the emerging pollutant crisis appears increasingly daunting, with the interaction between micro- and nanoplastics (M/NPs) and antimicrobial resistance (AMR) in complex microbial consortia remaining poorly understood. Here, mixed-...
ESM1 SUMOylation mediates bevacizumab resistance in ovarian cancer through ITGB1-FAK-driven angiogenesis [0.03%]
卵巢癌中ESM1SUMO化介导的贝伐单抗耐药性通过ITGB1-FAK驱动的血管生成发挥作用
Xiaomin Ran,Juan Zhang,Juan Yang et al.
Xiaomin Ran et al.
Bevacizumab (Bev) resistance limits therapeutic efficacy in ovarian cancer (OC) patients. We identified ESM1 as a key gene in Bev-resistant OC. ESM1 secreted by OC-resistant cell lines activates the ITGB1/FAK axis to induce neovascularizati...
Philippe Saikali,Maria Dzamukova,Christina Stehle et al.
Philippe Saikali et al.
Despite the crucial roles of GATA-3 in lymphocyte biology, little is known about its intracellular distribution and the mechanisms regulating its nuclear import. Single-cell analyses on confocal microscopy images revealed that GATA-3 was en...
Telomere-to-telomere assembly detects genomic diversity in Canadian strains of Borrelia burgdorferi [0.03%]
端粒到端粒基因组组装揭示了加拿大地区伯氏疏螺旋体的基因组多样性
Atia B Amin,Ana Victoria Ibarra-Meneses,Simon Gagnon et al.
Atia B Amin et al.
Borrelia burgdorferi, the bacteria causing Lyme disease, has a complex genome comprising a linear chromosome and multiple linear and circular plasmids. The atypical hairpin telomeres and the highly paralogous plasmids complicate genome asse...
Brief pulses of high-level fluid shear stress enhance metastatic potential and rapidly alter the metabolism of cancer cells [0.03%]
短暂的高剪切应力脉冲可增强癌细胞的转移潜能并迅速改变其代谢状态
Amanda N Pope,Devon L Moose,Guy O Hudson et al.
Amanda N Pope et al.
Circulating tumor cells (CTCs) face challenges to their survival, including mechanical and oxidative stresses that are different from cancer cells in solid primary and metastatic tumors. The impact of adaptations to the fluid microenvironme...
Spatiotemporal coordination of Slit-Robo repulsion and neurturin-Gfrα attraction guides multipolar migration during retinal lamination [0.03%]
Slit-Robo排斥和neurturin-Gfrα吸引的时空协调指导视网膜板层化过程中的多极迁移
Jaakko I Lehtimäki,Jingtao Lilue,Margarida R Cruz et al.
Jaakko I Lehtimäki et al.
Multipolar migration is a conserved neuronal migration mode in the developing brain, enabling emerging neurons to navigate in crowded environments and reach precise laminar positions. Yet, how these cells interpret external cues to guide th...
Distances and charges along the Orai1 nexus-TM3 interface control STIM1 binding and pore opening [0.03%]
ORAI1通道TM3结构域沿STIM1-ORAI1界面的相互作用距离和电荷决定了其结合与通道开放功能
Julia Söllner,Magdalena Prantl,Hadil Najjar et al.
Julia Söllner et al.
Calcium (Ca2+) influx through the Ca2+ release-activated Ca2+ (CRAC) channel is triggered by binding of the Ca2+ sensor STIM1 to the pore-forming Orai1 complex, primarily to its cytosolic C termini. These C termini connect to transmembrane ...
Delactylation of the tumor suppressor ARHGDIB drives metastasis and chemoresistance in bladder cancer [0.03%]
肿瘤抑制因子ARHGDIB的脱乳酸化驱动膀胱癌转移和化疗耐药性
Guanghui Xu,Yuqin Li,Shan Peng et al.
Guanghui Xu et al.
Emerging evidence has highlighted lactylation as a critical link between metabolism and tumor progression. Through integrative lactylome and proteome profiling, we delineate the global landscape of protein lysine lactylation in bladder canc...
Integrating natural and engineered genetic variations to decode regulatory influence on blood traits [0.03%]
结合自然和工程基因变异解码对血液性状的调控影响
Manuel Tardaguila,Dominique Von Schiller,Michela Colombo et al.
Manuel Tardaguila et al.
Understanding the function of genetic variants associated with human traits and diseases remains a significant challenge. Here, we combined analyses based on natural genetic variation and genetic engineering to dissect the function of 94 no...
Kristian J Herrera,Arman Zarghani-Shiraz,Misha B Ahrens et al.
Kristian J Herrera et al.
Animals reprioritize behavioral goals in response to internal physiological states. Using larval zebrafish, we investigated whether engagement with a visuomotor task, the optomotor response (OMR), is coupled to cardiac dynamics. We discover...