Distances and charges along the Orai1 nexus-TM3 interface control STIM1 binding and pore opening
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Calcium (Ca2+) influx through the Ca2+ release-activated Ca2+ (CRAC) channel is triggered by binding of the Ca2+ sensor STIM1 to the pore-forming Orai1 complex, primarily to its cytosolic C termini. These C termini connect to transmembrane (TM) domain 4 via th... ...
