Nuclear PD-L1 regulates YAP-driven transcription via the PGE2-EP4-YAP-importin α3 axis in solid tumors [0.03%]
核PD-L1通过PGE2-EP4-YAP-进口蛋白α3轴调节实体瘤中的YAP驱动转录
Shakti Ranjan Satapathy,Anita Sjölander
Shakti Ranjan Satapathy
Prostaglandin E2 (PGE2) is synthesized by cyclooxygenase 2 (COX-2) in the arachidonic acid pathway. PGE2 promotes cancer initiation and progression while facilitating chronic inflammation and immunosuppression, partly through regulation of ...
Ketogenic diet dampens excitatory neurotransmission by shrinking synaptic vesicle pools [0.03%]
生酮饮食通过减小突触小泡池来降低兴奋性神经传递
Marion I Stunault,Pan-Yue Deng,Anjali Yadav et al.
Marion I Stunault et al.
Ketogenic diet (KD) is used for the treatment of drug-resistant childhood epilepsy and has been proposed to improve outcomes in neurodegenerative diseases. However, the mechanisms by which KD alters brain circuitry remain unclear. Here, we ...
Ploidy and neuron size impact nervous system development and function in Xenopus [0.03%]
蛙类神经系统发育和功能的倍性及神经元大小研究
Xiao Liu,Christine Wan,Sara Aijaz Shah et al.
Xiao Liu et al.
Neuron size varies significantly over evolution, contributing to diverse nervous systems of variable complexity, while aberrant neuron size is associated with neurodevelopmental and degenerative diseases. How do neuron cell body and neurite...
Divya Choudhary,Maxence S Vincent
Divya Choudhary
Phenotypic heterogeneity is a defining feature of bacterial stress responses, long framed as irreducible noise arising from stochastic molecular events. This review builds on that view, advancing the idea that much of the apparent randomnes...
Histamine H3 receptors in the paraventricular thalamus link sleep loss to fat overconsumption [0.03%]
背侧丘脑室周核组胺H3受体通过调控睡眠不足促进过量摄食脂肪食物
Xinyue Zhao,Yuting Yan,Jingjia Liang et al.
Xinyue Zhao et al.
Sleep loss promotes obesity, yet the neural mechanisms linking disrupted sleep patterns to abnormal feeding behaviors remain unclear. By integrating the UK Biobank cohort analyses with mouse sleep restriction (SR) models, we demonstrate tha...
Revealing an unconventional JAK1/2-STAT3 branch in macrophage IFN-γ signaling [0.03%]
揭示巨噬细胞IFN-γ信号传导中的非典型JAK1/2-STAT3分支路径
Mees Botman,Josje M A Huisman,Alexandra Drakaki et al.
Mees Botman et al.
Interferon γ (IFN-γ) is a key cytokine in immune activation, especially anti-viral responses, and a driver of macrophage activation. It classically signals via JAK1/2-mediated STAT1 homodimers. Here, we identify an alternative, non-canoni...
Cell-type-independent infection dynamics of clinical Pseudomonas aeruginosa isolates in human airway epithelial models [0.03%]
临床获得的铜绿假单胞菌在人呼吸道上皮模型中的细胞类型非依赖性感染动力学
Claudia Antonella Colque,Signe Lolle,Ruggero La Rosa et al.
Claudia Antonella Colque et al.
Persistent bacterial infections pose major clinical challenges, particularly in people with cystic fibrosis (pwCF), in whom Pseudomonas aeruginosa can persist for decades despite antibiotic treatment. To investigate the host-pathogen intera...
Full dopamine coding of basic economic subjective value: Utility and weighted probability [0.03%]
全多巴胺编码的基本经济主观价值：效用和加权概率
Simone Ferrari-Toniolo,Leo Chi U Seak,Wolfram Schultz
Simone Ferrari-Toniolo
Behavioral choices of uncertain rewards suggest that agents construct subjective reward value by combining the basic value components of utility and weighted probability. Despite the general acceptance of this evaluation mechanism for expla...
Single-cell resolution functional networks during unconsciousness are segregated into spatially intermixed modules [0.03%]
无意识期间单细胞分辨率功能网络在空间上相互混杂的模块之间隔离分割
Daiki Kiyooka,Ikumi Oomoto,Jun Kitazono et al.
Daiki Kiyooka et al.
The common neural mechanisms underlying the reduction of consciousness during sleep and anesthesia remain unclear. Previous studies have examined changes in network structure by only using recordings with limited spatial resolution, which h...
SERPINA3 mediates liver cancer cells escape from chemotherapy-induced neutrophil extracellular trap killing [0.03%]
SERPINA3介导肝癌细胞逃逸化疗诱导的中性粒细胞胞外陷阱杀伤作用
Yuan Zhang,Cheng Zhao,Yongwei Zhao et al.
Yuan Zhang et al.
Although many chemotherapeutic agents induce neutrophil extracellular trap (NET) formation, how NETs affect therapeutic efficacy across different cancer types remains poorly understood. Here, we report that irinotecan-induced NETs exhibit d...