Revealing an unconventional JAK1/2-STAT3 branch in macrophage IFN-γ signaling
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Interferon γ (IFN-γ) is a key cytokine in immune activation, especially anti-viral responses, and a driver of macrophage activation. It classically signals via JAK1/2-mediated STAT1 homodimers. Here, we identify an alternative, non-canonical signaling compon... ...
