The conserved bridging domain on HCV E1E2 glycoprotein complex is targeted by neutralizing antibodies from diverse lineages [0.03%]
丙型肝炎病毒E1E2糖蛋白复合物保守的桥接区是中和抗体作用的关键位点
Fang Chen,Yen Thi Kim Nguyen,Yi-Zong Lee et al.
Fang Chen et al.
The bridging domain (BD) region on hepatitis C virus (HCV) E1E2 glycoprotein complex is a conserved, E1-dependent conformational site of vulnerability formed by E2 residues 646-704. Given its importance for rational vaccine design, here, we...
Phosphatidylserine synthesis tunes IP3R-mediated ER Ca2+ release via phospholipid homeostasis [0.03%]
磷脂稳态调节磷脂酰丝氨酸合成介导的IP3R依赖性内质网钙释放
Yifan Zhou,Meng Diao,Yaqiang Liu et al.
Yifan Zhou et al.
Regulation of phospholipid composition is essential for cellular homeostasis. Phosphatidylserine (PS) synthesized in the endoplasmic reticulum (ER) plays critical roles in the plasma membrane and endolysosomal system. Although aberrant PS m...
Cortical astrocytic neogenin, a key protein switching HIF1/2α-VEGFa-induced angiogenesis to MEGF10-driven phagocytosis [0.03%]
皮质星形胶质细胞中调控新生血管生成向吞噬作用转变的关键蛋白neogenin的作用机制研究
Ling-Ling Yao,Daehoon Lee,Min-Yi Wu et al.
Ling-Ling Yao et al.
Published Erratum
Cell reports. 2026 Aug 4;45(8):117842. DOI:10.1016/j.celrep.2026.117842 2026
Intratelencephalic neurons in the medial prefrontal cortex mediate the acquisition of goal-directed actions [0.03%]
内前额皮质的脑内神经元介导目标导向行为的获得
James N Peak,Sophia Liang,Benjamin K Lau et al.
James N Peak et al.
The medial prefrontal cortex (mPFC) and its connections with the posterior dorsomedial striatum are implicated in goal-directed learning, but the specific mPFC cell types involved have not been clearly established. The current study investi...
Mechanistic basis for calmodulin‑dependent allosteric activation of the neuropathy-associated formin INF2 [0.03%]
钙调蛋白依赖的神经病相关形式突变体INF2变构激活的机制基础
Bohan Zhang,Meng Zhang,Ke Liu et al.
Bohan Zhang et al.
Calcium signaling regulates the atypical formin INF2 to drive actin assembly in diverse cellular processes, yet the underlying molecular mechanism remains elusive. Here, we uncover a direct, nanomolar-affinity interaction between calcium-bo...
Architecture of distal tips of motile cilia is shaped by the pseudoenzyme Jhc1 in non-mammalian vertebrates [0.03%]
非哺乳动物纲生物通过伪酶Jhc1塑造运动纤毛远端顶端的精细结构
Juyeon Hong,Sidharth Ramu Nair,Ece Atayeter et al.
Juyeon Hong et al.
Motile cilia are evolutionarily conserved organelles performing essential roles in development and tissue homeostasis. Unlike the core scaffold, the distal regions remain relatively less explored and display great diversity across species. ...
Thermodynamics of consciousness: Non-equilibrium brain dynamics track conscious states [0.03%]
意识的热力学：非平衡脑动态跟踪意识状态
Tomas Berjaga-Buisan,Juan Manuel Monti,Martina Cortada et al.
Tomas Berjaga-Buisan et al.
The quest for reliable and objective measures of consciousness is critical in basic and clinical neuroscience. Across species, the perturbational complexity index (PCI) has emerged as a robust empirical marker by directly perturbing the bra...
The Receptor Tyrosine Kinase AXL Is Required at Multiple Steps of the Metastatic Cascade during HER2-Positive Breast Cancer Progression [0.03%]
HER2阳性乳腺癌进展过程中AXL受体酪氨酸激酶在转移级联的多个步骤中是必需的
Marie-Anne Goyette,Stéphanie Duhamel,Léo Aubert et al.
Marie-Anne Goyette et al.
Published Erratum
Cell reports. 2026 Jul 31;45(8):117807. DOI:10.1016/j.celrep.2026.117807 2026
Establishment of germline-encoded antibodies during primary dengue infection [0.03%]
初次感染登革病毒时胚系编码的抗体的建立
Thomas-Wolf Verdonckt,Marek Sahulčík,Johanna Bouckaert et al.
Thomas-Wolf Verdonckt et al.
Dengue viruses impose a major global health burden, while imperfect vaccines raise concerns that the immunization of dengue-naïve individuals may exacerbate disease through immunopathologic mechanisms. Using a controlled human challenge mo...
MCT4-mediated lactate efflux promotes STING-dependent dendritic cell antitumor immunity [0.03%]
MCT4介导的乳酸流出促进STING依赖性的树突状细胞抗肿瘤免疫
Rui Ding,Yaqing Yuan,Tongchang Xu et al.
Rui Ding et al.
The mechanisms by which DCs evolutionarily adapt to lactate accumulation to maintain their functions remain largely elusive. Here, our study highlights the MCT4-lactate axis as an intrinsic metabolic checkpoint governing intratumoral DC act...