Lineage tracing reveals a shared cellular origin for supraclavicular brown and inguinal beige adipocytes [0.03%]
谱系追踪揭示了锁骨上棕色脂肪细胞和股内浅色脂肪细胞具有相同的起源
Yali Ran,Kai Zhang,Yi-Ting Shen et al.
Yali Ran et al.
The metabolic importance of brown adipose tissue (BAT) has been recognized, but its origins, particularly supraclavicular BAT (scBAT), remain unclear. Here, we traced scBAT to Mef2c-anterior heart field (AHF)-marked cells. Mef2c-AHF-marked ...
Lung epithelial endothelin-1 drives iron dysregulation and skeletal injury after SARS-CoV-2 infection [0.03%]
肺上皮内皮素-1在SARS-CoV-2感染后铁代谢紊乱和骨骼损伤中的作用
Junguo Ni,Man Ting Au,Kaiming Tang et al.
Junguo Ni et al.
Post-COVID musculoskeletal disorders are not uncommon; yet the mechanisms linking SARS-CoV-2 respiratory infection to skeletal injury remain unclear. Here, we identify a lung-joint axis in which elevated endothelin-1 (ET-1) in alveolar type...
Succinate and its carrier Sfc1 mediate metabolic control of mitochondrial protein import by the TIM23 translocase [0.03%]
延胡索酸及其载体Sfc1通过TIM23转运酶介导三羧酸循环代谢对线粒体蛋白质导入的调控
Koyeli Das,Rituparna Samanta,Tamar Ziv et al.
Koyeli Das et al.
Tim23 is an essential component of the mitochondrial inner membrane translocase and Sfc1 is a carrier that exchanges succinate for fumarate across that membrane. Sfc1 and succinic acid availability regulate dual targeting of fumarase and ac...
EWSR1::FLI1 promotes neocentromere formation in ewing sarcoma cells [0.03%]
EWSR1::FLI1促进尤因肉瘤细胞中新着丝粒的形成
Risa Kitagawa,Ediri E Metitiri,Bin Yu et al.
Risa Kitagawa et al.
Ewing sarcoma (EwS) is characterized by chimeric fusions such as EWSR1::FLI1. Chromosome gain or loss is prevalent in EwS, and this chromosome instability (CIN) phenotype correlates with poor treatment outcomes. We previously showed that CE...
Melanoma exosomal hsa-miR-221-5p suppresses keratinocyte LL-37 to promote tumor progression [0.03%]
黑素瘤外泌体hsa-miR-221-5p通过抑制角质细胞LL-37促进肿瘤进展
Quan Sun,Ge Peng,Ziyou Wu et al.
Quan Sun et al.
Melanoma progression is regulated by not only tumor-intrinsic factors but also dynamic crosstalk with the surrounding epidermis. Here, we observed spatial suppression of cathelicidin LL-37 in tumor-adjacent epidermis compared with that in d...
Bailey J Didriksen,Emily M Eshleman,Taylor Rice et al.
Bailey J Didriksen et al.
Despite evidence highlighting immunoregulatory roles of tuft cells, it is not known whether vitamin A or retinoic acid affects tuft cell homeostasis. Here, we find that epithelial-intrinsic retinoic acid receptor regulates tuft cell numbers...
Quantitative single-base m6A profiling reveals dynamic reprogramming, evolutionary conservation and transcriptional regulation in bacteria [0.03%]
定量单碱基m6A测序揭示了细菌中m6A的动态重编程、保守性及转录调控
Youyue Li,Letong Xu,Na Liu et al.
Youyue Li et al.
N6-methyladenosine (m6A) is a widespread RNA modification that regulates RNA metabolism in eukaryotes, but its distribution and function in bacteria remain poorly defined. Here, we apply GLORI sequencing to generate single-base resolution t...
Spi-B and IRF1 activate tumor immunogenicity downstream of the Epstein-Barr virus protein LMP1 [0.03%]
EB病毒LMP1蛋白下游的 Spi-B 和 IRF1 激活肿瘤免疫原性
Keita Yamane,Yohei Kawano,Shun Ohki et al.
Keita Yamane et al.
Low immunogenicity hinders antitumor immunity and causes resistance to immunotherapies in solid tumors. We previously reported that enforced expression of latent membrane protein 1 (LMP1), encoded by the Epstein-Barr virus, enhances the imm...
Tgf-β receptor signaling cell-intrinsically controls conserved microglia homeostatic maturation during zebrafish development [0.03%]
tgf-β受体信号通过细胞内在机制控制斑马鱼发育过程中小胶质细胞稳态成熟过程中的保守性
Magali Miserocchi,Pauline De Meyer,Ruben Lattuca et al.
Magali Miserocchi et al.
Microglia, embryonically derived tissue-resident macrophages of the central nervous system, are essential for brain development, homeostasis, and disease. Although transforming growth factor β (TGF-β) signaling is required for mammalian m...
Stress granules confer an early vulnerability in KRAS-driven pancreatic tumorigenesis [0.03%]
KRAS驱动的胰腺肿瘤发生早期应激颗粒赋予的脆弱性
Matias Estaras,Emma Cosialls,Gareth Pollin et al.
Matias Estaras et al.
Pancreatic ductal adenocarcinoma (PDAC) is initiated by activating KRAS mutations, yet most pancreatic cells fail to survive the induced oncogenic stress. How a subset adapts to and initiates malignant transformation remains unclear. Here, ...