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Lung epithelial endothelin-1 drives iron dysregulation and skeletal injury after SARS-CoV-2 infection

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Post-COVID musculoskeletal disorders are not uncommon; yet the mechanisms linking SARS-CoV-2 respiratory infection to skeletal injury remain unclear. Here, we identify a lung-joint axis in which elevated endothelin-1 (ET-1) in alveolar type Ⅱ cells (AT2) disr... ...