Deubiquitylase OTUD3 regulates integrated stress response to suppress progression and sorafenib resistance of liver cancer [0.03%]
去泛素化酶OTUD3通过调节综合应激反应抑制肝癌的发生发展及索拉非尼耐药
Hongmiao Dai,Bo Wu,Yingwei Ge et al.
Hongmiao Dai et al.
Published Erratum
Cell reports. 2026 Aug 17;45(8):117784. DOI:10.1016/j.celrep.2026.117784 2026
Adipose GGPPS stabilizes BCAT2 to orchestrate BCAA catabolism and lipid mobilization in fasting-induced liver remodeling [0.03%]
脂肪GGPPS稳定BCAT2以协调禁食诱导的肝脏重塑中的支链氨基酸分解代谢和脂质动员
Hong-Yu Nie,Ming-Jie Zou,Meng-Fei Zhao et al.
Hong-Yu Nie et al.
Organisms adapt to fasting by remodeling energy metabolism across tissues. We identify geranylgeranyl pyrophosphate synthase (GGPPS) in white adipose tissue (WAT) as a fasting-responsive regulator that orchestrates lipolysis and branched-ch...
RAD51 proximity mapping reveals spatial constraints on homology search during DNA double-stranded break repair [0.03%]
RAD51邻近连接技术揭示了DNA双链断裂修复过程中的同源搜索的时空限制
Charles D Yeh,Lilly van de Venn,Susanne Kreutzer et al.
Charles D Yeh et al.
DNA double-stranded breaks (DSBs) are toxic events that can be reversed without genetic information loss by homology-directed repair (HDR), wherein information is copied from an intact template molecule. Finding a correct template within mi...
FANCJ and RTEL1 facilitate pre-replication complex disassembly following replisome collision [0.03%]
FANCJ和RTEL1在复制工厂碰撞后的前复制复合物解离中发挥作用
George Cameron,Simran Negi,Koichi Sato et al.
George Cameron et al.
At the onset of eukaryotic DNA replication, double hexamers of MCM2-7 are assembled into inactive pre-replication complexes (pre-RCs) at replication origins. An excess of pre-RCs is loaded onto DNA, but only a fraction becomes activated to ...
Reprogramming lineage-traced Müller glia for robust proliferation and neurogenesis in adult mammalian retinas [0.03%]
重编程谱系追踪的Müller胶质细胞以增强成年哺乳动物视网膜的增殖和神经发生
Ye Xie,Ying Xin,Thomas E Zapadka et al.
Ye Xie et al.
The therapeutic potential of adeno-associated virus (AAV)-mediated one-step glia-to-neuron conversion has been challenged following rigorous lineage-tracing analyses. In zebrafish, Müller glia (MG) serve as retinal stem cells to replenish ...
Calibration of CAR signaling promotes asymmetric cell division to direct CAR-T cell fate and antitumor potency [0.03%]
CAR信号校准促进不对称细胞分裂以决定CAR-T细胞命运和抗肿瘤功效
Xiaolin Shen,Xiaobao Xu,Jie Jiang et al.
Xiaolin Shen et al.
Asymmetric cell division (ACD) is an evolutionarily conserved mechanism that diversifies T cell fate, yet how engineered receptor signaling regulates ACD in chimeric antigen receptor (CAR)-T cells remains unknown. Here, we show that antigen...
Dietary soy fiber limits Salmonella infection by disrupting the self-reinforcing loop between pathogen virulence and host inflammation [0.03%]
大豆膳食纤维通过破坏病原体毒力和宿主炎症之间的相互促进作用来限制沙门氏菌感染
Wei Liu,Jinju Cai,Yanhu Huang et al.
Wei Liu et al.
The global threat of Salmonella Enteritidis (S. Enteritidis) is exacerbated by its ability to exploit host inflammation for colonization. Here, we find that dietary soy fiber (SF) confers colonization resistance by suppressing S. Enteritidi...
Synovial lining macrophages form during early postnatal life via fetal-derived CX3CR1+ cells and AQP1+ intermediates [0.03%]
胎儿衍生的CX3CR1+细胞和AQP1+中间体在出生后早期生命中形成滑膜巨噬细胞
Marlène S Magalhaes,Bert Malengier-Devlies,Guillaume Seuzaret et al.
Marlène S Magalhaes et al.
The synovial lining maintains joint integrity, produces lubricating fluid, and forms a sterile barrier disrupted in inflammatory joint disease. It consists of specialized fibroblasts and macrophages, but its developmental timing and mechani...
Tissue-level division of labor is coordinated across organs through universal programs and context-specific adaptations [0.03%]
组织层面的分工通过通用程序和特定情境下的适应在各个器官之间协调
Shira Yonassi,Noa Goldenberg,Avia Walfisch et al.
Shira Yonassi et al.
Fibroblasts, macrophages, and endothelial cells are common to most mammalian tissues, where they support homeostasis, repair, and immune regulation. Yet, how they coordinate functions across tissue environments remains unclear. Here, we ana...
Nuclear speckle-associated perispeckle networks partition active chromatin into gene expression niches [0.03%]
与核点相关的点周网络将活跃染色质划分到基因表达生态位中
Neha Chivukula Venkata,Jiah Kim,Saireet Misra et al.
Neha Chivukula Venkata et al.
A subset of genes, reproducibly positioned adjacent to nuclear speckles (NS), amplify their expression only with NS contact. However, genome-wide gene expression differences inversely correlate with differences in NS distance. To resolve th...