STING deficiency does not rescue short telomere-mediated aging phenotypes and longevity in TERC- or TERT-telomerase deficient mice [0.03%]
STING缺陷无法挽救端粒酶缺乏小鼠和TERC或TERT缺乏的小鼠的短端粒介导的老化表型和长寿
Rosa M Marión,José Carlos González,Juana M Flores et al.
Rosa M Marión et al.
The cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway plays a key role in responding to viral genomes and endogenous DNA byproducts by inducing inflammatory pathways. Its roles in senescence and in the response t...
Cholesterol enhances lysosome-autophagosome fusion for better α-synuclein clearance in GBA L444P-mutated Parkinson disease [0.03%]
胆固醇通过促进溶酶体-自噬体融合增强L444P突变GBA帕金森病患者α-突触核蛋白清除作用
Mingjia Chen,Fengtao Liu,Yujie Yang et al.
Mingjia Chen et al.
Mutations in lysosomal enzyme glucocerebrosidase (GBA), the most common genetic risk factor for Parkinson disease (PD), exacerbate α-synuclein pathology through unclear mechanisms. Here, we report, in a large cohort, that GBA-mutated PD pa...
The coordinated actions of metformin in the intestine and liver improves hyperglycemia [0.03%]
肠道和肝脏协同作用改善二甲双胍的降糖效果
Ling He,Hongying An,Karina Ramirez et al.
Ling He et al.
Metformin is the first-line oral anti-diabetic agent. Metformin concentrations in the intestine can reach up to 1.3 mM, while those in the portal vein are approximately 0.075 mM. It is unclear whether this metformin concentration difference...
Aanchal Bhatia,Mohamed Adel,Christine Grienberger
Aanchal Bhatia
The hippocampus is essential for spatial learning, yet how its principal output structure, the subiculum, encodes behaviorally relevant information during navigation remains poorly understood. Because subicular neurons exhibit prominent bur...
Adrija Pathak,Gregg B Wells,Vytas A Bankaitis et al.
Adrija Pathak et al.
Pediatric high-grade gliomas (HGGs) exhibit genetic profiles accompanied by anatomical specificities. These features suggest that specific anatomical niches favor the onset and/or progression of these diseases. However, such niche identitie...
A CEBPB-IPO4-FASN-MAVS axis limits innate immune activation and viral pneumonia [0.03%]
CEBPB-IPO4-FASN-MAVS轴限制先天免疫激活和病毒性肺炎发生
Jing Wu,Zihan Chen,Shengxiang Yin et al.
Jing Wu et al.
Dysregulation of innate immunity during respiratory RNA virus infections drives systemic hyperinflammation and lung injury. Here, we show that importin β4 (IPO4) has a role in inhibiting antiviral innate immunity. Transcriptomics analysis ...
ID2 Unlocks retinoic acid signaling to promote eosinophil maturation by antagonizing TCF3 [0.03%]
ID2通过拮抗TCF3促进视黄酸信号通路促进嗜酸性粒细胞成熟
Yubing Huang,Hao Wen,Jing Li et al.
Yubing Huang et al.
Novel functions of eosinophils are continually being discovered, yet the regulatory mechanisms underlying eosinophil development-particularly how ubiquitous nutrient metabolites integrate with cell-intrinsic transcriptional programs-remain ...
Circulating cochlin LCCL domain binds to dying cells and enhances efferocytosis [0.03%]
循环中的耳蛋白LCCL结构域结合于细胞凋亡体并增强其内吞作用
Louise Courcol,Ali Hassan,Zofia Haftek-Terreau et al.
Louise Courcol et al.
Clearance of dead cells by efferocytosis is a critical process for homeostasis, notably by limiting inflammation. Defective efferocytosis has been associated with autoimmune, neurodegenerative, and cardiovascular diseases, as well as chroni...
Telomere-to-telomere genome assembly of yellow-seeded rapeseed reveals BnaSCC1 regulates seed coat color and oil accumulation [0.03%]
油菜端粒到端粒基因组组装揭示BnaSCC1调控种皮颜色和油脂积累
Haijiang Liu,Kaijie Ye,Yiwen Xie et al.
Haijiang Liu et al.
Yellow-seeded rapeseed has higher oil content and seed quality than black-seeded varieties, but its genetic basis remains unclear. We report a telomere-to-telomere genome assembly of yellow-seeded rapeseed GH06 (981.18 Mb; contig N50, 56.93...
A telomere-to-telomere Brassica napus genome identifies BnaWRKY44 regulation of seed coat color and oil [0.03%]
一个端到端的油菜（Brassica napus）基因组鉴定出BnaWRKY44调节种子种皮颜色和油脂含量
Haijiang Liu,Yongheng Yuan,Kaijie Ye et al.
Haijiang Liu et al.
Brassica napus yellow-seeded genotypes have higher seed oil content and quality than black-seeded types, but the mechanisms controlling seed coat color (SCC) remain unclear, partly due to limited gap-free references. We generated the telome...