FANCJ and RTEL1 facilitate pre-replication complex disassembly following replisome collision
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At the onset of eukaryotic DNA replication, double hexamers of MCM2-7 are assembled into inactive pre-replication complexes (pre-RCs) at replication origins. An excess of pre-RCs is loaded onto DNA, but only a fraction becomes activated to form CMG helicases w... ...
