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Adipose GGPPS stabilizes BCAT2 to orchestrate BCAA catabolism and lipid mobilization in fasting-induced liver remodeling

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Organisms adapt to fasting by remodeling energy metabolism across tissues. We identify geranylgeranyl pyrophosphate synthase (GGPPS) in white adipose tissue (WAT) as a fasting-responsive regulator that orchestrates lipolysis and branched-chain amino acid (BCAA... ...