Structure of the Beat-Side complex reveals their interaction is required for neuromuscular system wiring [0.03%]
Beat复合物的结构表明其互作对于神经肌肉系统连接是必需的
Jessica M Priest,Ruiling Zhang,Agnieszka M Olechwier et al.
Jessica M Priest et al.
Nervous system assembly is guided by the actions of cell surface receptors. In Drosophila, members of the beaten path (Beat) and sidestep (Side) protein families have been described as axon guidance receptor-cue pairs, in addition to roles ...
Distinct metabolic dependency on BCAA defines cancer stemness and malignancy in human triple-negative breast cancer [0.03%]
人类三阴性乳腺癌小鼠模型中独特的支链氨基酸代谢依赖性定义了癌症干细胞特性及恶性程度
Kenkyo Matsuura,Ririko Shinonaga,Mizuki Yamamoto et al.
Kenkyo Matsuura et al.
Triple-negative breast cancer (TNBC) lacks effective molecularly targeted therapies. Here, we identify branched-chain amino acid (BCAA) metabolism as a selective vulnerability in human TNBC, particularly in the claudin-low subtype. TNBC cel...
Zhimeng Li,Baihui Chi,Chujin Ruan et al.
Zhimeng Li et al.
The rare biosphere harbors immense microbial diversity, yet most low-abundance taxa remain uncultured and functionally enigmatic. Here, we isolated strain D14T from deep-sea water, and propose to classify it as a novel species, Metabolovari...
Time-resolved proteolipidomics of the human aorta identifies stage-specific lipid-protein modules across development and aging [0.03%]
人主动脉的时间分辨蛋白质脂质组学鉴定出发育和衰老过程中的阶段特异性脂蛋白模块
Hao Cui,Sin Man Lam,Yiqi Zhao et al.
Hao Cui et al.
An established vascular network is a prerequisite to ensuring an optimal supply of oxygen and nutrients for sustaining developmental events and systemic function. Herein, we construct a time-resolved proteolipidomic atlas of the aorta acros...
Jagged1+ Tregs mediate lymphatic remodeling in tumor-draining lymph nodes [0.03%]
肿瘤引流淋巴结中Jagged1+调节性T细胞介导淋巴结构重塑
Jessie Z Xu,Pei-Hsun Tsai,Prudence PokWai Lui et al.
Jessie Z Xu et al.
Tumor-draining lymph nodes (tdLNs) undergo extensive stromal remodeling during tumor progression, but the immune signals that shape this process remain unclear. Here, using the B16-F10 melanoma model, we examine the role of Jagged1-expressi...
Combining genotoxic gut bacterial strains increases tumor burden and accelerates onset in a germ-free mouse model of colon carcinogenesis [0.03%]
结合基因毒性肠道菌株可增加无菌小鼠结肠癌变模型中的肿瘤负荷并加速发病时间
Tamar Plitt,Alix Piessevaux,Urvija Rajpal et al.
Tamar Plitt et al.
To identify causal links between gut microbes and tumorigenesis, we colonized germ-free, colon tumor-susceptible mice (ApcMin/+;Il10-/-) with 19 cultured human fecal microbiotas from healthy individuals and patients with inflammatory bowel ...
Striatal neuron dysfunction in C9ORF72-FTD/ALS is driven by AIS and potassium channel dysregulation [0.03%]
C9ORF72-FTD/ALS中岛状细胞功能障碍由轴突起始段和钾通道调节异常驱动
Iris-Stefania Pasniceanu,Manpreet S Atwal,Cleide Dos Santos Souza et al.
Iris-Stefania Pasniceanu et al.
Frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) form a neurodegenerative spectrum characterized by progressive cognitive, behavioral, and motor decline, yet the contribution of the striatum to disease pathophysiology r...
Lectins of the Emp47/ERGIC-53 family target misfolded O-mannosylated ER proteins to ER-associated degradation [0.03%]
Emp47/ERGIC-53家族 lectin 将错折叠的O-甘露糖基化内质网蛋白靶向至内质网相关降解中
Leticia Lemus,Veit Goder
Leticia Lemus
O-mannosylation of misfolded endoplasmic reticulum (ER) proteins in Saccharomyces cerevisiae by the bifunctional O-mannosyltransferase complex Pbn1-Gpi14 generates signals for ER-associated degradation (ERAD), but how these signals are reco...
Single-nucleotide RNA m6A mapping in bovine preimplantation development reveals site-specific regulation of RPL12 at zygotic genome activation [0.03%]
单碱基分辨率的牛早期胚胎m6A图谱揭示了RPL12在合子基因组激活过程中的特异调控
Rajan Iyyappan,Yichi Niu,Yang Li et al.
Rajan Iyyappan et al.
RNA N6-methyladenosine (m6A) is a key regulator of gene expression during early embryogenesis. Using SAC-seq (m6A-selective allyl chemical labeling and sequencing), an antibody-independent m6A profiling method, we generated the first single...
K M Daly,Xiaoyi Li,Shubham Rathore et al.
K M Daly et al.
Intrinsically photosensitive retinal ganglion cells (ipRGCs) in mice are comprised of at least 6 morphological subtypes, known as M1 to M6. While the M1-ipRGC subtype is well characterized, directly linking cellular manipulation of other su...