Lectins of the Emp47/ERGIC-53 family target misfolded O-mannosylated ER proteins to ER-associated degradation
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O-mannosylation of misfolded endoplasmic reticulum (ER) proteins in Saccharomyces cerevisiae by the bifunctional O-mannosyltransferase complex Pbn1-Gpi14 generates signals for ER-associated degradation (ERAD), but how these signals are recognized remains unkno... ...
