Combining genotoxic gut bacterial strains increases tumor burden and accelerates onset in a germ-free mouse model of colon carcinogenesis
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To identify causal links between gut microbes and tumorigenesis, we colonized germ-free, colon tumor-susceptible mice (ApcMin/+;Il10-/-) with 19 cultured human fecal microbiotas from healthy individuals and patients with inflammatory bowel disease or colorecta... ...