Multiplexing of functionally distinct inputs by intrinsic modulation of spike timing in a monoaminergic nucleus [0.03%]
多胺能核通过固有调制刺激时间来复用功能不同的输入信号
Michael Lynn,Leonard Maler,Jean-Claude Béïque
Michael Lynn
Monoaminergic nuclei such as the serotonergic dorsal raphe nucleus (DRN) receive functionally distinct streams of synaptic inputs, yet whether and how these are transformed into distinct population codes remains unknown. Combining electroph...
Jim Zoladek,Marion Cannac,Claire Lacouture et al.
Jim Zoladek et al.
HIV-1 release from infected cells requires coordinated action of the viral Gag protein and the host endosomal sorting complexes required for transport (ESCRT) machinery. How innate immunity regulates ESCRT function to limit viral egress rem...
Citrullination of cathepsin H promotes NETs formation and exacerbates IBD via PI3K-Akt pathway [0.03%]
瓜氨酸化Cathepsin H通过PI3K-Akt途径促进NETs形成并加重IBD病情
Yi-Hang Song,Feng-Xing Huang,Lun Gu et al.
Yi-Hang Song et al.
Peptidyl arginine deiminase 4 (PAD4) is previously known for its role in inflammatory bowel disease (IBD) through its facilitation of neutrophil extracellular traps (NETs) by citrullinating histones. However, the specific citrullinated subs...
Strain-level ecological filtering governs microbial colonization of the human gut [0.03%]
应生态位过滤人类肠道微生物定植的菌株水平规律
Isabel Baertschi,Sebastian B U Jordi,Lucie Jeanne Gardaz et al.
Isabel Baertschi et al.
Microbial colonization of the human gut is typically inferred from species-level profiling, yet durable establishment operates at the strain level. Here, using longitudinal shotgun metagenomics across multiple donor-recipient pairs undergoi...
SARS-CoV-2 ORF7a drives mitochondrial dysfunction via PDK4 activation and complex I inhibition [0.03%]
SARS-CoV-2 ORF7a通过PDK4激活和复合物I抑制引起线粒体功能障碍
Raúl Fernández-Rodríguez,Carmen M Soto-Jiménez,Rebeca Acín-Pérez et al.
Raúl Fernández-Rodríguez et al.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection reprograms host metabolism to favor viral replication and immune evasion, yet the contribution of accessory proteins remains poorly defined. Here, we characterize the me...
Natural allelic variation of TMS6 regulates branching and is associated with latitudinal adaptation in soybean [0.03%]
大豆TMS6基因自然变异影响分枝并与其纬度适应有关
Dan Gu,Doudou Chen,Qianjin Liang et al.
Dan Gu et al.
Increase in branching boosts soybean yield but often causes delayed flowering, thereby limiting its application in high-latitude regions with short frost-free periods. Here, through positional cloning, we identify a branching-regulating gen...
Molecular basis of the HPV E7-ZER1 axis reveals a ligandable vulnerability in HPV-positive cancers [0.03%]
HPV E7-ZER1轴的分子基础揭示了HPV阳性癌症中的一个可药物靶向的弱点
Xiaolu Wang,Chenhao Jiang,Yueling Zhao et al.
Xiaolu Wang et al.
Persistent infection with high-risk human papillomaviruses (HPVs), notably HPV-16 and HPV-18, underlies most cervical cancers and many head and neck cancers. Here, we report the structural and functional basis by which the viral oncoprotein...
Neutrophil-promoted macrophage state transition coordinates endothelial migration and barrier resealing in zebrafish microvascular repair [0.03%]
中性粒细胞促进巨噬细胞状态转变以协调斑马鱼微血管修复中的内皮细胞迁移和屏障封闭作用
Xiaoping Zhang,Ran Ai,Yingjie Zeng et al.
Xiaoping Zhang et al.
Microvessels are frequently damaged, yet the in vivo temporal logic that couples endothelial gap closure to barrier resealing, and the immune-cell interactions that coordinate these steps, remains poorly defined. Using live imaging of laser...
Tissue-resident colon macrophages shape the microbiome and regulate mucosal healing via ferroportin [0.03%]
结肠驻留巨噬细胞通过铁调素形塑肠道菌群并调节黏膜愈合
Bhupendra Singh Rawat,Jaehyeon Kim,Waleed Mujib et al.
Bhupendra Singh Rawat et al.
Inflammatory bowel diseases (IBDs) are complex disorders marked by microbial dysbiosis and dysregulated iron. Iron homeostasis is controlled by endogenous hepcidin, which inhibits iron export through ferroportin, to promote mucosal healing ...
Dynamic acetylation of a metabolic enzyme orchestrates spore stability and germination to facilitate host infection [0.03%]
代谢酶的动态乙酰化调控孢子稳定性和萌发以促进宿主感染
Qianqian Yang,Fugen Yang,Xiaojun Yuan et al.
Qianqian Yang et al.
Fungal spores maintain viability and then germinate to infect host plants, but how these biological processes are integrated remains elusive. Here, we show that γ-carboxymuconolactone decarboxylase 1 (FolCmd1) is an acetylated protein reve...