Citrullination of cathepsin H promotes NETs formation and exacerbates IBD via PI3K-Akt pathway
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Peptidyl arginine deiminase 4 (PAD4) is previously known for its role in inflammatory bowel disease (IBD) through its facilitation of neutrophil extracellular traps (NETs) by citrullinating histones. However, the specific citrullinated substrates have not been... ...
