Genomic characterization of the emerging multidrug-resistant Klebsiella pneumoniae ST6668 clone in northern Italy, 2020-2025 [0.03%]
意大利北部2020-2025年新出现的多重耐药肺炎克雷伯菌ST6668型基因组特征分析
Maryam Omrani,Virginia Batignani,Kiarash Moghaddasi et al.
Maryam Omrani et al.
Carbapenem-resistant Klebsiella pneumoniae carrying New Delhi metallo-β-lactamase (NDM) enzymes poses a major clinical and public health challenge due to their ability to spread rapidly in hospitals, and their resistance to most β-lactam ...
Large temperature excursions have modest impacts on community composition in the high diversity gut microbiome of omnivorous American cockroaches (Periplaneta americana) [0.03%]
温度剧烈波动对杂食性美洲蜚蠊高度多样化肠道菌群的群落组成影响有限
Kevin C Riedmuller,Josey E Dyer,Elizabeth A Ottesen
Kevin C Riedmuller
Microbial residents of ectothermic hosts are exposed to variations in temperature that have the potential to impact their physiology and the host-microbe symbiotic relationship. In this experimental warming study, laboratory populations of ...
Sequential receptor engagement dictates the broad host range and fitness trade-offs of Salmonella phage PSA5-1 [0.03%]
受体识别顺序决定沙门氏菌噬菌体PSA5-1的广谱宿主范围和适应性折中
Muhammad Saleem Iqbal Khan,Yuan Li,Shenlin Ji et al.
Muhammad Saleem Iqbal Khan et al.
The global rise of multidrug-resistant (MDR) Salmonella spp. necessitates the development of alternative antimicrobials, yet the molecular determinants of phage host range and the collateral effects of bacterial resistance remain poorly def...
Biocontrol potential and mechanism of an endophytic Bacillus subtilis strain KS1 against fire blight [0.03%]
一株枯草芽孢杆菌内生菌KS1的生物控害潜力及机制研究
Jingbo Dang,Yunneng Wei,Yuan Jiang et al.
Jingbo Dang et al.
Fire blight, caused by Erwinia amylovora, is one of the serious challenges in the production of pears and apples. In this study, we isolated and analyzed the biocontrol efficiency and underlying mechanisms of strain KS1, an antagonistic bac...
Trypanosoma brucei TEL2 inhibits VSG switching and protects PIKKs from the 26S proteasome-mediated degradation [0.03%]
非洲锥虫TEL2基因通过抑制变性表面糖蛋白转换并使PIKK家族成员免受泛素介导的降解来稳定表达克隆型主效变异表型
Sk Abdus Sayeed,Prem P Kushwaha,Marjia Afrin et al.
Sk Abdus Sayeed et al.
Trypanosoma brucei causes debilitating human African trypanosomiasis. It undergoes antigenic variation and sequentially expresses distinct VSGs, its major surface antigen, thereby effectively evading the host's immune response. We have show...
Comparative analysis of selective fungal culture media and incubation conditions for Aspergillus fumigatus in cystic fibrosis sputum [0.03%]
用于囊性纤维化痰标本中烟曲霉选择性真菌培养基和培养条件的比较分析研究
Gina Hong,Elisa M Vesely,Warda Memon et al.
Gina Hong et al.
Aspergillus fumigatus detection in respiratory samples of people with cystic fibrosis (CF) is important for the diagnosis of Aspergillus-related lung disease. Yet, fungal culture approaches are not standardized for clinical CF respiratory s...
Harnessing lytic phages for biofilm control in carbapenem-resistant Klebsiella pneumoniae causing urinary tract infection [0.03%]
利用裂解噬菌体控制尿路感染中碳青霉烯耐药肺炎克雷伯菌生物膜
Dipendra Kumar Mandal,Elisha Upadhyaya,Puja Dahal et al.
Dipendra Kumar Mandal et al.
Klebsiella pneumoniae is an opportunistic pathogen with rising multidrug resistance and biofilm-related infections. Molecular and phage characterization is crucial to understand resistance mechanisms and explore alternative therapies, such ...
A conserved Delftibactin A biosynthetic gene cluster plays an important role in the biocontrol of kiwifruit bacterial canker by Delftia lacustris ZWP15 [0.03%]
芽孢杆菌系多糖生物合成基因簇在奇异果细菌性溃疡病生防菌德氏树干缘单胞菌ZWP15中的保守性和重要作用研究
Jing Huang,Weipeng He,Yifei Liang et al.
Jing Huang et al.
Kiwifruit bacterial canker (KBC), caused by Pseudomonas syringae pv. actinidiae (Psa), is a globally devastating disease with limited sustainable control options. Here, we report Delftia lacustris strain ZWP15 as a novel biocontrol agent ex...
Harnessing gut microbiome enzymes: Segatella copri and Stenotrophomonas maltophilia prolyl peptidases degrade gliadin peptides and improve epithelial barrier function in a celiac disease model [0.03%]
利用肠道微生物酶：Segatella copri和Stenotrophomonas maltophilia脯氨酰肽酶可降解无菌小鼠乳糜泻模型中的麦胶蛋白肽并改善上皮屏障功能
Bhagyashree Karmarkar,Dhiraj Dhotre
Bhagyashree Karmarkar
Celiac disease (CeD) is an autoimmune enteropathy triggered by gluten-derived peptides that resist gastrointestinal digestion, notably the proline-rich 33-mer and 11-mer gliadin epitopes. Here, we describe a rational, metagenome-based strat...
Global epidemiology of Helicobacter pylori iceA genotypes: heterogeneity and virulence implications [0.03%]
幽门螺杆菌iceA基因型的全球流行病学：异质性和毒力含义
Yayi Ren,Jia Xie,Long Zhou et al.
Yayi Ren et al.
The contact-induced epithelium gene A (iceA), with allelic variants iceA1 and iceA2, remains a controversial virulence factor in Helicobacter pylori due to inconsistent clinical outcomes. In this study, we analyzed 1,427 H. pylori genomes f...