Trypanosoma brucei TEL2 inhibits VSG switching and protects PIKKs from the 26S proteasome-mediated degradation
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Trypanosoma brucei causes debilitating human African trypanosomiasis. It undergoes antigenic variation and sequentially expresses distinct VSGs, its major surface antigen, thereby effectively evading the host's immune response. We have shown that many telomer... ...