Bis-CF3‑bipyridine Ligands for the Iridium-Catalyzed Borylation of N‑Methylamides [0.03%]
N‑甲基酰胺的铱催化硼化反应中的双三氟甲基联吡啶配体
Daniel Marcos-Atanes,Gonzalo Jiménez-Osés,José L Mascareñas
Daniel Marcos-Atanes
Bipyridine and phenanthroline are well-established neutral ligands for promoting iridium-catalyzed borylations of aromatic C-H bonds. However, their use with aliphatic substrates is almost uncharted. Herein we demonstrate that introducing C...
Mechanistic Insights into GTP Hydrolysis by the RhoA Protein: Catalytic Impact of Glutamine Tautomerism [0.03%]
格蛋白RhoA催化解聚三磷酸鸟苷的机制见解——谷氨酰胺互变异构作用的催化效应
Jorge Pardos,Adrián García-Martínez,J Javier Ruiz-Pernía et al.
Jorge Pardos et al.
We present a systematic evaluation of different possible reaction mechanisms for GTP hydrolysis in RhoA, a member of the Ras superfamily of enzymes that uses this reaction to switch from an active to an inactive conformation. These enzymes ...
Solving the Conundrum of the Influence of Irradiation Power on Photothermal CO2 Hydrogenation [0.03%]
辐射功率对光热CO2氢化影响的解谜
Horatiu Szalad,Yong Peng,Jonas Werner Gosch et al.
Horatiu Szalad et al.
Solar photocatalysis appears as a viable approach for the production of value-added chemicals from CO2. However, up to now, there is no information on the influence of the light intensity on the product distribution of CO2 hydrogenation and...
Photoredox/Nickel-Catalyzed Diastereoselective Allylation of Aldehydes with Morita-Baylis-Hillman Adducts [0.03%]
光氧化还原/镍催化醛与Morita-Baylis-Hillman加合物的对映选择性共轭烯丙基化反应
Francesco Calogero,Emanuele Pinosa,Andrea Gualandi et al.
Francesco Calogero et al.
A practical diastereoselective photoredox nickel-mediated allylation of aliphatic and aromatic aldehydes with Morita-Baylis-Hillman (MBH) acetates is reported here. The reaction proceeds under visible-light irradiation using MBH derivatives...
α-Hydrazino Acids Inhibit Pyridoxal Phosphate-Dependent Decarboxylases via "Catalytically Correct" Ketoenamine Tautomers: A Special Motif for Chemical Biology and Drug Discovery? [0.03%]
α-肼基酸通过“催化正确”酮亚胺烯胺异构体抑制吡哆醛磷酸依赖性脱羧酶：化学生物学和药物发现的一个特殊模式？
Jonathan M Baine,Yoan Duhoo,Tzanko Doukov et al.
Jonathan M Baine et al.
We present evidence that supports a 'correct hydrazone tautomer/Dunathan alignment model' for how α-hydrazino analogues of α-amino acids inhibit PLP enzymes. Described is the asymmetric synthesis of l- and d-α-hydrazino acid l-lysine ana...
Organocatalytic Asymmetric Synthesis of Azabicyclo[2.1.1]hexanes [0.03%]
有机催化剂介导的Azabicyclo[2.1.1]己烷不对称合成
Layth Alama,Nils Frank,Lennart Brücher et al.
Layth Alama et al.
The bioisosteric replacement of 2D aromatic scaffolds with sp3-rich surrogates has become an important design element in modern medicinal chemistry. Within the sp3-rich world, the azabicyclo[2.1.1]hexane (aza-BCH) scaffold stands out as a p...
Acidic Oxygen Evolution Reaction Activity, Stability, and Durability of Copper and/or Manganese Cobalt Oxide Spinels [0.03%]
铜和/或锰钴氧化物尖晶石的酸性析氧反应活性、稳定性和耐久性
Christopher Pantayatiwong Liu,Ethan Hwjchim Vang,Tatiana Priamushko et al.
Christopher Pantayatiwong Liu et al.
Cu and Mn was incorporated into Co spinels and the structural and electrochemical properties of the resulting materials were investigated. Cu and Mn were found to reside exclusively in the octahedral sites in the spinel lattice. The incorpo...
Reversible Substrate-Specific Photocontrol of the Chemotherapeutic Asparaginase(-Glutaminase) from Escherichia coli [0.03%]
一种可逆的底物特异性光控化疗药物——大肠杆菌天冬酰胺酶（谷氨酰胺酶）
Mona Wieland,Jonnely Luizaga,Cristina Duran et al.
Mona Wieland et al.
Photoswitchable unnatural amino acids are valuable engineering tools in biotechnology, particularly for the reversible control of enzymes with light. Here, we explore some basic principles of this protein engineering technique to simplify i...
Keto-Polyethylene Material from Pd(II)-Catalyzed Copolymerization with Continuous Carbon Monoxide Feed [0.03%]
连续通入二氧化碳的钯催化酮聚乙烯共聚合反应合成 ketogenic 聚乙烯材料
Steffen Iberl,Maria Voccia,Ida Ritacco et al.
Steffen Iberl et al.
Pd(II) phosphinosulfonate catalysts were employed in the nonalternating copolymerization of ethylene and carbon monoxide to produce keto-polyethylenes with high-density polyethylene-like materials properties. The different reactivities of t...
Deciphering Size and Shape Effects on the Structure Sensitivity of the CO2 Methanation Reaction on Nickel [0.03%]
解密尺寸和形状对镍上二氧化碳甲烷化反应结构敏感性的影响
Gabriele Spanò,Matteo Ferri,Raffaele Cheula et al.
Gabriele Spanò et al.
This study advances the understanding of structure sensitivity in CO2 methanation over nickel-based catalysts by highlighting the combined influence of the metal nanoparticle (NP) size and shape on catalytic performance. Density functional ...