Mitochondria as crucial players in demyelinated axons: lessons from neuropathology and experimental demyelination [0.03%]
线粒体在线轴脱髓鞘中的重要作用：来自神经病理学和实验性脱髓鞘的启示
Graham R Campbell,Don J Mahad
Graham R Campbell
Mitochondria are the most efficient producers of energy in the form of ATP. Energy demands of axons, placed at relatively great distances from the neuronal cell body, are met by mitochondria, which when functionally compromised, produce rea...
A Nonsecosteroidal Vitamin D Receptor Modulator Ameliorates Experimental Autoimmune Encephalomyelitis without Causing Hypercalcemia [0.03%]
一种非甾体维生素D受体调节剂可改善实验性自身免疫性脑脊髓炎且不会导致高钙血症
Songqing Na,Yanfei Ma,Jingyong Zhao et al.
Songqing Na et al.
Vitamin D receptor (VDR) agonists are currently the agents of choice for the treatment of psoriasis, a skin inflammatory indication that is believed to involve an autoimmune component. 1,25-dihydroxyvitamin D3 [1,25-(OH)(2)D(3)], the biolog...
Effects of IFN-B on TRAIL and Decoy Receptor Expression in Different Immune Cell Populations from MS Patients with Distinct Disease Subtypes [0.03%]
干扰素β对不同免疫细胞群体中TRAIL及其诱骗受体表达的影响
Andrea L O Hebb,Craig S Moore,Virender Bhan et al.
Andrea L O Hebb et al.
Using quantitative RT-PCR, we compared mRNA levels for TRAIL [tumor necrosis factor (TNF)-related apoptosis-inducing ligand] and its receptors in various immune cell subsets derived from the peripheral blood of untreated normal subjects (NS...
Multiple sclerosis: are protective immune mechanisms compromised by a complex infectious background? [0.03%]
复杂的感染背景会破坏多发性硬化症的保护性免疫机制吗？
Bernd Krone,John M Grange
Bernd Krone
The immunological background of multiple sclerosis (MS) manifests as an altered reactivity against a diverse range of infections, particularly with the Epstein-Barr virus. Although this could be only an epiphenomenon of a more generalised d...
Heterogeneity in multiple sclerosis: scratching the surface of a complex disease [0.03%]
多发性硬化症的异质性：揭开这种复杂疾病的面纱
Giulio Disanto,Antonio J Berlanga,Adam E Handel et al.
Giulio Disanto et al.
Multiple Sclerosis (MS) is the most common demyelinating disease of the central nervous system. Although the etiology and the pathogenesis of MS has been extensively investigated, no single pathway, reliable biomarker, diagnostic test, or s...
Mechanisms of oxidative damage in multiple sclerosis and a cell therapy approach to treatment [0.03%]
氧化应激在多发性硬化症发病机制中的作用及其细胞治疗研究进展
Jonathan Witherick,Alastair Wilkins,Neil Scolding et al.
Jonathan Witherick et al.
Although significant advances have recently been made in the understanding and treatment of multiple sclerosis, reduction of long-term disability remains a key goal. Evidence suggests that inflammation and oxidative stress within the centra...
Antigen-Experienced CD4lo T Cells Are Linked to Deficient Contraction of the Immune Response in Autoimmune Diabetes [0.03%]
低CD4抗原免疫经验T细胞与自身免疫糖尿病中免疫反应收缩缺陷有关
Sean Linkes,Christopher Fry,Anthony Quinn
Sean Linkes
Following proper activation, naïve "CD4lo" T cells differentiate into effector T cells with enhanced expression of CD4 -"CD4hi" effectors. Autoimmune diabetes-prone NOD mice display a unique set of antigen-experienced "CD4lo" T cells that ...
5-androstenediol ameliorates pleurisy, septic shock, and experimental autoimmune encephalomyelitis in mice [0.03%]
5-雄内烯二醇改善小鼠胸膜炎、脓毒症休克和实验性自身免疫性脑脊髓炎
Ferdinando Nicoletti,Dominick L Auci,Katia Mangano et al.
Ferdinando Nicoletti et al.
Androstenediol (androst-5-ene-3β,17β-diol; 5-AED), a natural adrenal steroid, has been shown to suppress experimental autoimmune encephalomyelitis (EAE) in female SJL/J mice. We here report that 5-AED limits inflammation and proinflammato...
Anna A Kasperlik-Zaluska,Barbara Czarnocka,Wojciech Jeske et al.
Anna A Kasperlik-Zaluska et al.
This study aimed at comparing two groups of patients with Addison's disease: A, including 180 patients described in 1991 and B, consisting of 138 patients registered since 1991. The incidence of coexisting autoimmune disorders was evaluated...
Fc γ RIIA Genotypes and Its Association with Anti-C1q Autoantibodies in Lupus Nephritis (LN) Patients from Western India [0.03%]
印度西部狼疮肾炎患者中FC γ RIIA基因型与抗C1q抗体的相关性研究
Vandana Pradhan,Manisha Patwardhan,Anita Nadkarni et al.
Vandana Pradhan et al.
To identify Fc γ RIIA genotypes in Systemic Lupus Erythematosus (SLE) patients and their association with anti-C1q antibodies. Methods. Fc γ RIIA genotyping was done in eighty Indian SLE patients and eighty healthy controls using allele-s...