Inflammatory demyelinating central nervous system diseases in childhood: clinical and paraclinical profiles in 133 patients [0.03%]
儿童炎症性脱髓鞘中枢神经系统疾病的临床和辅助检查特征（133例报告）
Derya Kaya,Egemen Idiman,Serkan Ozakbaş
Derya Kaya
In a retrospective review of patients with acquired demyelinating disorders of the central nervous system, 133 patients (5.6%) whose diseases started in childhood, were selected from 2369 patients, who had medical records in the Neurology D...
Eiji Kawamoto,Susumu Nakahashi,Takayuki Okamoto et al.
Eiji Kawamoto et al.
Integrins are the foremost family of cell adhesion molecules that regulate immune cell trafficking in health and diseases. Integrin alpha4 mediates organ-specific migration of immune cells to the inflamed brain, thereby playing the critical...
Theranostic implications of nanotechnology in multiple sclerosis: a future perspective [0.03%]
纳米技术在多发性硬化诊疗中的应用及未来展望
Ajay Vikram Singh,Manish Khare,W N Gade et al.
Ajay Vikram Singh et al.
Multiple Sclerosis is a multifactorial disease with several pathogenic mechanisms and pathways. Successful MS management and medical care requires early accurate diagnosis along with specific treatment protocols based upon multifunctional n...
Pawel Stocki,Anne M Dickinson
Pawel Stocki
Heat shock protein 70 (HSP70) has previously been described as a potent antitumour vaccine. The mechanism relied on the ability of tumour derived HSP70 to associate with antigenic peptides, which, when cross presented, elicited a T cell med...
Autoantibodies in senear-usher syndrome: cross-reactivity or multiple autoimmunity? [0.03%]
老年型尤塞伯综合征中的自身抗体：交叉免疫反应或多重自身免疫？
María Elena Pérez-Pérez,Esperanza Avalos-Díaz,Rafael Herrera-Esparza
María Elena Pérez-Pérez
Senear-Usher syndrome or pemphigus erythematosus is a pathology that overlaps clinically and serologically with pemphigus foliaceus and lupus erythematosus. Skin biopsies of patients with pemphigus erythematosus reveal acantholysis and depo...
Use of Complementary and Alternative Medicine among People with Multiple Sclerosis in the Nordic Countries [0.03%]
北欧国家多发性硬化症患者使用补充和替代医学的情况
L Skovgaard,P H Nicolajsen,E Pedersen et al.
L Skovgaard et al.
Aims. The aim of the study was to describe and compare (1) the types and prevalence of complementary and alternative medicine (CAM) treatments used among individuals with multiple sclerosis (MS) in the Nordic countries; (2) the types of con...
Impact of exercise and metabolic disorders on heat shock proteins and vascular inflammation [0.03%]
运动和代谢障碍对热休克蛋白和血管炎症的影响
Earl G Noble,Garry X Shen
Earl G Noble
Heat shock proteins (Hsp) play critical roles in the body's self-defense under a variety of stresses, including heat shock, oxidative stress, radiation, and wounds, through the regulation of folding and functions of relevant cellular protei...
Cost-effectiveness of multiple sclerosis disease-modifying therapies: a systematic review of the literature [0.03%]
多发性硬化症疾病修正疗法的成本效益：文献综述
David Yamamoto,Jonathan D Campbell
David Yamamoto
Objective. To provide a current and comprehensive understanding of the cost-effectiveness of DMTs for the treatment of MS by quantitatively evaluating the quality of recent cost-effectiveness studies and exploring how the field has progress...
Simone Appenzeller,Yehuda Shoenfeld,Jozélio Freire de Carvalho
Simone Appenzeller
Multicenter retrospective analysis of the effectiveness and safety of rituximab in korean patients with refractory systemic lupus erythematosus [0.03%]
利妥昔单抗治疗难治性系统性红斑狼疮疗效及安全性的多中心回顾性分析
So-Young Bang,Chang Keun Lee,Young Mo Kang et al.
So-Young Bang et al.
Objective. Although two recent randomized placebo-controlled trials of rituximab (RTX) failed to demonstrate efficacy in systemic lupus erythematosus (SLE), clinicians continue to use off-label RTX for cases refractory to current treatments...