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Antigen-Experienced CD4lo T Cells Are Linked to Deficient Contraction of the Immune Response in Autoimmune Diabetes

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Following proper activation, naïve "CD4lo" T cells differentiate into effector T cells with enhanced expression of CD4 -"CD4hi" effectors. Autoimmune diabetes-prone NOD mice display a unique set of antigen-experienced "CD4lo" T cells that persist after primar... ...