Epigenetic and Neurogenomic Mechanisms Linking Physical Activity to Brain Plasticity and Cognitive Function [0.03%]
表观遗传及神经基因组机制连接体力活动与脑可塑性及认知功能
Agata Leońska-Duniec
Agata Leońska-Duniec
Background/Objectives: Physical activity is one of the most powerful lifestyle factors influencing brain health, with growing evidence supporting its role in promoting neuroplasticity, cognitive function, and resilience to age-related neuro...
The Genome-Wide Identification and Expression Profiling of the HSF Gene Family in Ganoderma lucidum Under Temperature Stress [0.03%]
热休克条件下高温烧灼菌HSF基因家族的鉴定及表达分析
Jinyu Hu,Yihong Li,Shaohua Wu et al.
Jinyu Hu et al.
Objective: In this study, the heat shock transcription factor (HSF) gene family in Ganoderma lucidum was systematically characterized. Using genomic and transcriptomic data, we identified HSF family members and investigat...
Enrichment of Rare Variants in Nuclear-Encoded Mitochondrial Metabolism Genes in Patients with Early-Onset or Familial Parkinson's Disease [0.03%]
帕金森病患者中罕见变异在核编码线粒体代谢基因中的富集
Gaber Bergant,Vesna M van Midden,Polina Tsygankova et al.
Gaber Bergant et al.
Introduction: Parkinson's disease (PD) is a prevalent neurodegenerative disorder, with several proposed pathogenic mechanisms. Given the established role of mitochondrial dysfunction in PD, this study seeks to investigate the enrichment of ...
Genomic Signatures of Somatic Mutation and Selection Shape Distinct Clonal Lineages in Bougainvillea × buttiana 'Miss Manila' Bud Sport [0.03%]
基因组突变和选择印记塑造了毛叶苞清剪枝芽变异中独特的克隆系谱特征
Hongyan Meng,Qun Zhou,Duchao Chen et al.
Hongyan Meng et al.
Background/Objectives: Bud sports (somatic mutations) offer a quick way to develop new bougainvillea varieties by altering specific traits while keeping the desirable genetic background of the original cultivar. However, we still lack a com...
Integrated Insights into Drought Tolerance Mechanism of the Autotetraploid from Gossypium herbaceum by Transcriptome and Physiological Analyses [0.03%]
通过转录组和生理分析研究Gossypium herbaceum自体型四倍体耐旱机制的综合见解
Lili Feng,Lexiang Wang,Jiamin Li et al.
Lili Feng et al.
Background: Information on the autopolyploid of Gossypium herbaceum remains limited until now. Previously, the autotetraploid of G. herbaceum was successfully generated via colchicine-induced chromosome doubling from the ...
Genome-Wide Identification of the PME Gene Family in Plum and Its Potential Roles in Fruit Texture Formation [0.03%]
榅桲PME基因家族的全基因组鉴定及其在果实质地形成中的潜在作用
Longji Li,Yu Wang,Siyu Li et al.
Longji Li et al.
Background: Fruit texture is a major component of plum quality, affecting both consumer acceptance and postharvest behavior. Pectin methylesterases (PMEs) play important roles in cell-wall pectin modification and are ther...
Population-Specific Mutational Spectrum of Autosomal Recessive Nonsyndromic Hearing Loss in Croatian Roma: Implications for Clinical Genetics [0.03%]
克罗地亚吉卜赛人常染色体隐性非综合征听力损失的种群特异性突变谱：对临床遗传学的意义
Iva Kutija Fučkar,Matea Zajc Petranović,Irena Martinović Klarić et al.
Iva Kutija Fučkar et al.
Background/objectives: Hearing impairment is a highly prevalent sensory disorder resulting from a variety of causes. A high proportion of autosomal recessive non-syndromic hearing impairment is linked to the GJB2 (OMIM 12...
Precision Medicine Through Network Language: Integrating Clinical Insight and Data Expertise [0.03%]
精准医疗中的网络语言：临床洞察力和数据分析的融合
Maria Concetta Palumbo,Lorenzo Farina,Manuela Petti
Maria Concetta Palumbo
Precision medicine is facing a critical transition driven by the growing complexity of biological data and the insufficient ability of current models to translate such data into clinically meaningful information. Linear, single-gene approac...
Multi-Omics Mendelian Randomization and Clinical Validation Implicate NLRP6 as a Candidate Autophagy-Related Gene in Systemic Lupus Erythematosus [0.03%]
多组学孟德尔随机化和临床验证将NLRP6鉴定为系统性红斑狼疮自噬相关候选基因
Daan Nie,Jianguo Yin,Wei Tu et al.
Daan Nie et al.
Background/Objectives: Autophagy plays a role in systemic lupus erythematosus (SLE) pathogenesis. Nevertheless, the specific genetic determinants underpinning this process remain poorly characterized. Summary data-based Mendelian randomizat...
Neuronal Ceroid Lipofuscinosis-like Disorder in a Dachshund with Sequence Variants in Lysosome-Related Genes [0.03%]
具有溶酶体相关基因序列变异的达克斯猎犬中的神经元脑苷脂贮积症样障碍
Joan R Coates,Kristen Keyes,Rebecca E H Whiting et al.
Joan R Coates et al.
Background/objectives: Among the most common hereditary neurodegenerative disorders in people are the neuronal ceroid lipofuscinoses (NCLs), a subgroup of lysosomal storage disorders. For most cases of NCL, the genes cont...
Case Reports
Genes. 2026 Apr 15;17(4):465. DOI:10.3390/genes17040465 2026