Genome-Wide Identification, Expression, and Functional Analysis of UDP-Glucose Dehydrogenase Family Genes in Rhus chinensis [0.03%]
中国漆树UDP-葡萄糖脱氢酶家族基因的全基因组鉴定、表达和功能分析
Guang Ba,Ke Hu,Youyang Wang et al.
Guang Ba et al.
Background: Uridine diphosphate glucose (UDP-Glc) is one of the key substrates for the biosynthesis of gallotannins in plants. UDP-glucose dehydrogenase (UGD) catalyzes the irreversible oxidation of UDP-Glc to UDP-glucuronic acid (UDP-GlcA)...
A Comprehensive Analysis of the Agreement and Performance of Variant Annotation Programs in Equine Genomes [0.03%]
马基因组变异注释程序的协议和性能的全面分析
Jillian L Marlowe,Lauren Hughes,Eric Barrey et al.
Jillian L Marlowe et al.
Background/Objectives: Advances in whole-genome sequencing (WGS) technology have led to the widespread adoption of WGS for investigating genetic diseases and traits in domestic animals. This has created a need for improved methods for prior...
Clinical and Genetic Spectrum of ANO3-Related Dystonia with Treatment Responses in a Chinese Cohort [0.03%]
以治疗反应为导向的中国ANO3相关性肌张力不全患者的临床及遗传特点分析
Jie-Hong Huang,Yang Li,Zhi-Meng Wan et al.
Jie-Hong Huang et al.
Background: Variants in anoctamin 3 (ANO3) are linked to autosomal dominant dystonia, commonly known as DYT-ANO3 (OMIM: #615034). While craniocervical dystonia constitutes the most frequently observed phenotype, its clinical manifestations ...
Hong Zhang,Xiao-Qing Hu,Ning Li et al.
Hong Zhang et al.
Background/Objectives: As the most prevalent supraventricular arrhythmia, affecting around 1% of people worldwide, atrial fibrillation (AF) is implicated with a multitude of detrimental clinical sequelae, encompassing congestive failure, th...
Genome-Wide Identification of the MYB Family in Morus atropurpurea and Functional Characterization of MaDIV for Its Possible Involvement in Anthocyanin Biosynthesis [0.03%]
基于染色体水平基因组的桑树R2R3-MYB转录因子家族鉴定及其成员MaDIV参与花青素生物合成的功能分析
Xuefei Chen,Yixin Liang,Xingxing Liu et al.
Xuefei Chen et al.
Background: Anthocyanin biosynthesis is tightly controlled by MYB transcription factors, yet the role of repressors, particularly those in the DIVARICATA-like (DIV) subfamily, remains poorly characterized. Methods: A genome-wide identificat...
Genome-Wide Analysis of the Banana NBS Gene Family and Expression Profiling of the Fusarium Wilt Resistance Gene MamRGA2 in Response to Defense-Related Phytohormones [0.03%]
香蕉NBS基因家族的全基因组分析及其抗枯萎病基因MamRGA2对防御相关植物激素响应表达谱分析
Ana N Roblero-Aguilar,Gabriel Lizama-Uc,Carlos Alberto Puch-Hau et al.
Ana N Roblero-Aguilar et al.
Background/Objectives: Banana (Musa spp.) production is severely threatened by Fusarium wilt caused by Fusarium oxysporum f. sp. cubense tropical race 4 (Foc TR4), highlighting the need to identify genetic determinants of resistance. Method...
In Silico Identification and Structural Characterization of High-Risk Missense SNVs in the Human IL23R Gene Relevant to Inflammatory Bowel Disease [0.03%]
人类IL23R基因中与炎症性肠病相关的高风险错义SNV的计算机识别及结构特征分析
Gamze Altintas Kazar
Gamze Altintas Kazar
Background/objectives: IL23R encodes a pivotal component of the IL-23/Th17 signaling axis and represents a validated genetic susceptibility locus for inflammatory bowel disease (IBD), psoriasis, and ankylosing spondylitis...
MicroRNA-Mediated Post-Transcriptional Regulation of Cytochrome P450s [0.03%]
微小核糖核酸介导的细胞色素P450mRNA转录后调控
Qi-Hang Yu,Sohaib Shahid,Jia-Yi Wu et al.
Qi-Hang Yu et al.
The rapid evolution of metabolic resistance to chemical insecticides and the adaptation to plant allelochemicals in insect pests have become major challenges in global pest management. While the overexpression of cytochrome P450 monooxygena...
Trm7/FTSJ1-Mediated tRNA Anticodon-Loop 2'-O-Methylation: From Structural Mechanisms to Translational Dysfunction and Disease [0.03%]
由Trm7/FTSJ1介导的tRNA反密码子环2'-O甲基化：从结构机制到翻译功能障碍及疾病
Huan Sheng,Jun Yao
Huan Sheng
Transfer RNAs (tRNAs) are chemically matured decoding molecules that are central to protein synthesis. Their post-transcriptional modifications, especially those in the anticodon stem-loop (ASL), shape local RNA structure, codon recognition...
Integrative Transcriptomic Analysis and Single-Cell Validation Identify a Six-Hub-Gene Signature Converging on Inflammatory Signaling in Osteoarthritis [0.03%]
整合转录组分析及单细胞验证鉴定出软骨特异性促炎症六基因模块收敛于骨关节炎中炎症信号通路
Xueya Lv,Yang Yu,Jiawen Fan et al.
Xueya Lv et al.
Background: Osteoarthritis (OA) is a heterogeneous joint disease characterized by cartilage degeneration. The interplay between extracellular matrix (ECM) remodeling, endoplasmic reticulum (ER) stress, and inflammatory si...