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Trm7/FTSJ1-Mediated tRNA Anticodon-Loop 2'-O-Methylation: From Structural Mechanisms to Translational Dysfunction and Disease

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Transfer RNAs (tRNAs) are chemically matured decoding molecules that are central to protein synthesis. Their post-transcriptional modifications, especially those in the anticodon stem-loop (ASL), shape local RNA structure, codon recognition and translational f... ...