Nanoparticle-based multivalent human antibodies offer potent and broad neutralization against Omicron sublineages [0.03%]
基于纳米颗粒的多价人源抗体对奥密克戎亚系提供 potent 和广谱的中和作用
Yizhen Wang,Feibo Song,Siling Wang et al.
Yizhen Wang et al.
Gold nanoparticles combat enveloped RNA virus by affecting organelle dynamics [0.03%]
金纳米颗粒通过影响细胞器动力学来对抗具包膜的RNA病毒
Fangzhou Li,Qianqian Huang,Ziran Zhou et al.
Fangzhou Li et al.
Enveloped RNA viruses are a group of viruses with an outer membrane derived from a host cell and a genome consisting of ribonucleic acid (RNA). These viruses rely on host cell machinery and organelles to replicate and assemble new virus par...
Function and Cryo-EM structures of broadly potent bispecific antibodies against multiple SARS-CoV-2 Omicron sublineages [0.03%]
针对多种SARS-CoV-2奥密克戎亚系的广谱双特异性抗体的功能和冷冻电镜结构
Ping Ren,Yingxia Hu,Lei Peng et al.
Ping Ren et al.
Cellular mechanotransduction in health and diseases: from molecular mechanism to therapeutic targets [0.03%]
细胞机械力转换的分子机制及作用靶点：从健康到疾病
Xingpeng Di,Xiaoshuai Gao,Liao Peng et al.
Xingpeng Di et al.
Cellular mechanotransduction, a critical regulator of numerous biological processes, is the conversion from mechanical signals to biochemical signals regarding cell activities and metabolism. Typical mechanical cues in organisms include hyd...
Metabolic reprogramming of proinflammatory macrophages by target delivered roburic acid effectively ameliorates rheumatoid arthritis symptoms [0.03%]
雷公藤红素代谢重编程促炎性巨噬细胞有效改善类风湿关节炎症状的新机制研究
Na Jia,Yunzhen Gao,Min Li et al.
Na Jia et al.
Rheumatoid arthritis (RA) is a common chronic inflammatory disorder that usually affects joints. It was found that roburic acid (RBA), an ingredient from anti-RA herb Gentiana macrophylla Pall., displayed strong anti-inflammatory activity. ...
Interaction between neutrophil extracellular traps and cardiomyocytes contributes to atrial fibrillation progression [0.03%]
中性粒细胞胞外陷阱与心肌细胞相互作用促进房颤进展
Li He,Ruiqi Liu,Honghua Yue et al.
Li He et al.
Atrial fibrillation (AF) is a frequent arrhythmia associated with cardiovascular morbidity and mortality. Neutrophil extracellular traps (NETs) are DNA fragments with cytoplasm proteins released from neutrophils, which are involved in vario...
Destroying pathogen-tumor symbionts synergizing with catalytic therapy of colorectal cancer by biomimetic protein-supported single-atom nanozyme [0.03%]
一种基于仿生蛋白的单原子纳米酶协同催化治疗摧毁结直肠癌病原体肿瘤共生体的研究
Xinyue Wang,Qian Chen,Yefei Zhu et al.
Xinyue Wang et al.
The crucial role of intratumoral bacteria in the progression of cancer has been gradually recognized with the development of sequencing technology. Several intratumoral bacteria which have been identified as pathogens of cancer that induce ...
Tingmei Zhao,Yulong Cai,Yujie Jiang et al.
Tingmei Zhao et al.
Adjuvants are indispensable components of vaccines. Despite being widely used in vaccines, their action mechanisms are not yet clear. With a greater understanding of the mechanisms by which the innate immune response controls the antigen-sp...
Cancer cell employs a microenvironmental neural signal trans-activating nucleus-mitochondria coordination to acquire stemness [0.03%]
癌细胞利用微环境神经信号活化核线粒体协调以获得干细胞特性
Bin He,Rui Gao,Shasha Lv et al.
Bin He et al.
Cancer cell receives extracellular signal inputs to obtain a stem-like status, yet how tumor microenvironmental (TME) neural signals steer cancer stemness to establish the hierarchical tumor architectures remains elusive. Here, a pan-cancer...