Dun Niu,Yaran Wu,Jiqin Lian
Dun Niu
CircRNAs are a class of single-stranded RNAs with covalently linked head-to-tail topology. In the decades since its initial discovery, their biogenesis, regulation, and function have rapidly disclosed, permitting a better understanding and ...
Temporospatial inhibition of Erk signaling is required for lymphatic valve formation [0.03%]
时空抑制Erk信号通路对形成淋巴管瓣膜是必需的
Yaping Meng,Tong Lv,Junfeng Zhang et al.
Yaping Meng et al.
Intraluminal lymphatic valves (LVs) and lymphovenous valves (LVVs) are critical to ensure the unidirectional flow of lymphatic fluid. Morphological abnormalities in these valves always cause lymph or blood reflux, and result in lymphedema. ...
Targeting copper to combat macrophage-driven inflammation: a potential advanced therapeutic strategy [0.03%]
靶向铜以对抗巨噬细胞驱动的炎症：潜在的先进治疗策略
Ralf Weiskirchen
Ralf Weiskirchen
Qi Li,Wenyuan Qian,Yang Zhang et al.
Qi Li et al.
Genome instability has been identified as one of the enabling hallmarks in cancer. DNA damage response (DDR) network is responsible for maintenance of genome integrity in cells. As cancer cells frequently carry DDR gene deficiencies or suff...
A metabolome atlas of mouse brain on the global metabolic signature dynamics following short-term fasting [0.03%]
小鼠短期饥饿后的脑代谢轮廓及整体代谢标志变化图集
Yaping Shao,Zhenfa Fu,Yanfeng Wang et al.
Yaping Shao et al.
Calorie restriction (CR) or a fasting regimen is considered one of the most potent non-pharmacological interventions to prevent chronic metabolic disorders, ameliorate autoimmune diseases, and attenuate aging. Despite efforts, the mechanism...
Cancer cells evade ferroptosis: sex hormone-driven membrane-bound O-acyltransferase domain-containing 1 and 2 (MBOAT1/2) expression [0.03%]
癌细胞逃逸铁死亡：性激素驱动的膜结合O-酰基转移酶结构域含1和2（MBOAT1/2）表达
Alexia Belavgeni,Wulf Tonnus,Andreas Linkermann
Alexia Belavgeni
Mitochondrial dynamics in health and disease: mechanisms and potential targets [0.03%]
健康与疾病中的线粒体动力学：机制和潜在作用靶点
Wen Chen,Huakan Zhao,Yongsheng Li
Wen Chen
Mitochondria are organelles that are able to adjust and respond to different stressors and metabolic needs within a cell, showcasing their plasticity and dynamic nature. These abilities allow them to effectively coordinate various cellular ...
I prostanoid receptor activation attenuates pressure overload-induced cardiac hypertrophy by enhancing glucose oxidation [0.03%]
前列腺素受体活化通过增强葡萄糖氧化缓解压力超负荷诱导的心脏肥厚
Qian Liu,Guizhu Liu,Yujuan Zhuo et al.
Qian Liu et al.
Recent advances in targeting the "undruggable" proteins: from drug discovery to clinical trials [0.03%]
不可药物作用蛋白的药物研发新进展：从发现到临床试验
Xin Xie,Tingting Yu,Xiang Li et al.
Xin Xie et al.
Undruggable proteins are a class of proteins that are often characterized by large, complex structures or functions that are difficult to interfere with using conventional drug design strategies. Targeting such undruggable targets has been ...
Fumarate hydratase: a new checkpoint of metabolic regulation in inflammatory macrophages [0.03%]
富马酸水合酶：炎症巨噬细胞中代谢调控的新节点
Aicha Jeridi,Theodore S Kapellos,Ali Önder Yildirim
Aicha Jeridi